Endothelial SIRT3 deficiency predisposes brown adipose tissue to whitening in diet-induced obesity [0.03%]
内皮SIRT3缺陷使米色脂肪组织在饮食诱导的肥胖中易于白色化
Qing Zhou,Zongshi Lu,Bowen Wang et al.
Qing Zhou et al.
Endothelial dysfunction and vascular rarefaction are supposed to be secondary to metabolic diseases, while recent evidence has revealed the primary roles of endothelium in initiating and accelerating metabolic disorders. Here, the effects a...
The Role of Gut Microbiota in Tirzepatide-Mediated Alleviation of High-Fat Diet-Induced Obesity [0.03%]
肠道微生物群在 tirzepatide 介导的高脂饮食诱导的肥胖缓解中的作用
Ruonan Wang,Zijing Lin,Mingjie He et al.
Ruonan Wang et al.
Purpose: In this study, we aim to explore the effects of tirzepatide on the gut microbiota in mice with obesity induced by a high-fat diet. Methods: ...
Myometrial smooth muscle Katp channel activity is attenuated in a mouse model of diet-induced obesity during pregnancy [0.03%]
在肥胖小鼠妊娠模型中子宫平滑肌Katp通道活性下降
Tsuyoshi Murata,Kevin K Prifti,Xiaofeng Ma et al.
Tsuyoshi Murata et al.
Labor dystocia occurs in 21% of deliveries, increasing the risk of adverse maternal and neonatal outcomes. Pregnant women with obesity have an increased prevalence of labor dystocia due to reduced myometrial contractility. Similarly, in a m...
Dietary Flaxseed Oil and Its Blended Oil Alleviate High-Fat Diet-Induced Obesity in Mice by Improving Lipid Metabolism and Regulating Gut Microbiota [0.03%]
亚麻籽油及其调和油通过改善脂质代谢和调节肠道菌群缓解小鼠高脂饮食诱导的肥胖症
Haizhen Li,Mingyue Shen,Xianxiang Chen et al.
Haizhen Li et al.
Obesity represents a chronic metabolic disorder feature by dysregulated glucose-lipid homeostasis. We investigated the effects of flaxseed oil (FO), rich in α-linolenic acid, and its blended oil (BO) on high-fat diet-induced obese mice. In...
Effects of Sleeve Gastrectomy and Treadmill Exercise on Skeletal Muscle and Ectopic Fat in High-Fat Diet-Induced Obese Rats [0.03%]
袖状胃切除术和跑步机运动对高脂饮食诱导的肥胖大鼠骨骼肌和异位脂肪的影响
Takaaki Noguchi,Yuichi Yoshida,Koro Gotoh et al.
Takaaki Noguchi et al.
A high-fat diet (HFD) can lead to obesity and skeletal muscle atrophy. Sleeve gastrectomy (SG) improves obesity and increases skeletal muscle mass. This study examined whether SG prevented skeletal muscle atrophy in a diet-induced rat obesi...
Celastrol improves endothelial function in diet-induced obesity mice via attenuating endoplasmic reticulum stress through the activation of AMPK pathway [0.03%]
Celastrol通过激活AMPK通路减轻内质网应激改善饮食诱导的肥胖小鼠内皮功能
Cheng Yu,Weihong Lin,Jing Yang et al.
Cheng Yu et al.
Background: Diet-induced obesity (DIO) is a significant factor in endothelial dysfunction. Celastrol, a potent anti-inflammatory and anti-oxidative pentacyclic triterpene, has shown promise as a protective agent against c...
Rifampicin prevents diet-induced obesity through Sirt6-dependent lipolysis, adipocyte browning and lipogenesis inhibition [0.03%]
利福平通过Sirt6依赖性脂解、促棕色脂肪生成和抑制脂质合成预防饮食诱导的肥胖作用机制研究
Yang Xu,Lei Cao,Xiaoyuan Guo et al.
Yang Xu et al.
Rifampicin (RFP) is a semi-synthetic macrocyclic broad-spectrum antibiotic known for its ability to inhibit bacterial proliferation. However, its potential role of obesity treatment has not been explored. We unveil a novel function of rifam...
Sex impact on daily activity and physiological, metabolic and hormonal responses to different photoperiod regimens in diet-induced obese fischer 344 rats [0.03%]
性别对饮食诱导的肥胖Fischer大鼠不同光周期方案下的日常活动及生理、代谢和激素反应的影响
Saioa Gómez-Roncal,Aina Gironès-Garreta,Manuel Suárez et al.
Saioa Gómez-Roncal et al.
Diet-induced obesity promotes endothelial cell desensitization to VEGF-A and permanent islet vessel dysfunction in mice [0.03%]
饮食诱导的肥胖促进小鼠胰岛内皮细胞对VEGF-A去敏和永久性血管功能障碍
Yan Xiong,Andrea Dicker,Montse Visa et al.
Yan Xiong et al.
Pancreatic islet microvasculature is essential for optimal islet function and glucose homeostasis. However, islet vessel pathogenesis in obesity and its role in the manifestation of metabolic disorders remain understudied. Here, we depict t...
Effect of viable and inactivated Lactobacillus rhamnosus GG administration on the prevention of diet-induced obesity in rats: implication of white and brown adipose tissue and influence of bacterial viability [0.03%]
罗伊特格氏乳杆菌活菌和灭菌对预防大鼠饮食诱导性肥胖的影响：白色及棕色脂肪组织的改变与细菌活力的关系
Laura Arellano-García,María P Portillo,J Alfredo Martínez et al.
Laura Arellano-García et al.
Obesity is one of the most prevalent chronic metabolic alterations worldwide being highly related to an increased risk for further associated co-morbidities. Current evidence indicates that subjects with obesity have a distinct gut microbio...
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