Intensity-modulated proton therapy for hippocampal-sparing prophylactic cranial irradiation: a planning comparison with photon therapy [0.03%]
调强质子治疗用于海马保留预防性全脑放疗的计划研究与光子治疗的对比
Xiaoyan Yin,Xiutong Lin,Guifang Zhang et al.
Xiaoyan Yin et al.
Background: The purpose of the study was to evaluate the dosimetric characteristics of volumetric modulated arc therapy (VMAT), helical tomotherapy (HT), and intensity-modulated proton therapy (IMPT) and to compare the do...
Comparative Study
BMC cancer. 2025 Apr 8;25(1):639. DOI:10.1186/s12885-025-14039-6 2025
Effects of EGFR-TKIs combined with intracranial radiotherapy in EGFR-mutant non-small cell lung cancer patients with brain metastases: a retrospective multi-institutional analysis [0.03%]
表皮生长因子受体酪氨酸激酶抑制剂联合全脑放疗治疗表皮生长因子受变非小细胞肺癌患者疗效的多中心回顾性分析
Mingfeng He,Xue Wu,Li Li et al.
Mingfeng He et al.
Background: Patients with non-small cell lung cancer (NSCLC) are prone to developing brain metastases (BMs), particularly those with epidermal growth factor receptor (EGFR) mutations. In clinical practice, treatment-naïv...
Multicenter Study
Radiation oncology (London, England). 2025 Jan 9;20(1):6. DOI:10.1186/s13014-024-02578-4 2025
Hippocampal protection during preventive cranial irradiation and neurocognitive functions in patients with small cell lung cancer [0.03%]
预防性全脑照射中海马保护与小细胞肺癌患者的神经认知功能的关系
Karolina Loga,Bartosz Wojcik,Anna Stanislawek et al.
Karolina Loga et al.
Background: In small cell lung cancer (SCLC), limiting the radiation dose in the hippocampus area during preventive cranial irradiation (PCI) can reduce nerve injury and cognitive decline. This study was done to compare c...
Optimal intervention timing for craniocerebral radiotherapy in EGFR mutant lung adenocarcinoma patients with brain metastases [0.03%]
EGFR突变型肺癌脑转移患者颅内放射治疗干预时机的优化研究
Guangchuan Deng,Qunxing Zhang,Jing Fan et al.
Guangchuan Deng et al.
Background: Intracranial radiation in combination with EGFR targeted therapy demonstrated signals of superiority to EGFR targeted therapy alone based on several observational studies. The timing based on specific criteria...
BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences [0.03%]
脑部放射治疗诱导的认知能力下降和神经退行性病变的BDNF增效逆转作用
Sanad M El-Khatib,Arya R Vagadia,Anh C D Le et al.
Sanad M El-Khatib et al.
Cranial radiation therapy (RT) for brain cancers is often associated with the development of radiation-induced cognitive dysfunction (RICD). RICD significantly impacts the quality of life for cancer survivors, highlighting an unmet medical ...
Brain volume loss after cranial irradiation: a controlled comparison study between photon vs proton radiotherapy for WHO grade 2-3 gliomas [0.03%]
颅内放射治疗后的脑容量损失：质子疗法与光子疗法治疗WHO II-III级胶质瘤的对照研究
Melissa M Gardner,Sebastian F Winter,Franziska Stahl et al.
Melissa M Gardner et al.
Purpose: Radiation therapy (RT) is an integral treatment component in patients with glioma but associated with neurotoxicity. Proton RT (PRT), as compared with photon RT (XRT), reduces excess radiation to nontarget tissue...
Scalp dose analysis for transient and permanent alopecia following conventional cranial irradiation using Image Guided Radiotherapy (IGRT): A prospective study [0.03%]
图像引导放射治疗（IGRT）指导下的常规颅脑放射治疗后脱发的头皮剂量分析：一项前瞻性研究
Bongkot Jia-Mahasap,Wannapha Nobnop,Patumrat Sripan et al.
Bongkot Jia-Mahasap et al.
Purpose: The dosimetry of scalp dose was prospectively studied and correlated with alopecia following conventional cranial irradiation in primary brain tumors patients. ...
BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences [0.03%]
脑部放射治疗引起的认知衰退和神经退行性后果的脑源性神经营养因子增强疗法
Sanad M El-Khatib,Arya R Vagadia,Anh C D Le et al.
Sanad M El-Khatib et al.
Cranial radiation therapy (RT) for brain cancers is often associated with the development of radiation-induced cognitive dysfunction (RICD). RICD significantly impacts the quality of life for cancer survivors, highlighting an unmet medical ...
A biomarker exploration in small-cell lung cancer for brain metastases risk and prophylactic cranial irradiation therapy efficacy [0.03%]
小细胞肺癌脑转移风险及预防性全脑放疗疗效的生物标志物探索研究
Li Li,Ning Liu,Tao Zhou et al.
Li Li et al.
Background: Small-cell lung cancer (SCLC) is an aggressive malignancy with a poor prognosis. Limited-stage (LS)-SCLC comprises only one-third of SCLC cases, resulting in limited molecularly targeted therapies and treatmen...
Are Dual-Phase 18F-Fluorodeoxyglucose PET-mpMRI Diagnostic Performances to Distinguish Brain Tumour Radionecrosis/Recurrence after Cranial Radiotherapy Usable in Routine? [0.03%]
双相18F-FDG PET-mpMRI鉴别颅脑放射治疗后肿瘤放射性坏死和复发的诊断性能可用于常规诊疗吗？
Axel Cailleteau,Ludovic Ferrer,Delphine Geffroy et al.
Axel Cailleteau et al.
Brain metastases or primary brain tumours had poor prognosis until the use of high dose radiotherapy. However, radionecrosis is a complex challenge in the post-radiotherapy management of these patients due to the difficulty of distinguishin...
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