Re-Evaluating Recurrent Events in Heart Failure Trials: Patterns, Prognostic Implications, and Analytical Improvements [0.03%]
心力衰竭试验中反复发生事件的再评价：模式、预后意义和分析改进
Audinga-Dea Hazewinkel,John Gregson,Stuart J Pocock et al.
Audinga-Dea Hazewinkel et al.
Analyses using repeat hospitalizations (HFHs) are common in heart failure trials and typically assume that such repeat events occur randomly over time. Also, many think that using repeat events enhances statistical power. This article chall...
Predicting Heart Failure Outcomes Using Patient-Reported Health Status: Real-World Validation of the KCCQ-12 [0.03%]
基于患者报告的健康状态预测心力衰竭预后：KCCQ-12量表真实世界验证研究
Bassim R El-Sabawi,Mohammed A Al-Garadi,Bryan D Steitz et al.
Bassim R El-Sabawi et al.
Background: The Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12), a patient-reported outcome measure for adults with heart failure, is associated with hospitalizations and mortality in clinical trials. Curated data s...
Age at diagnosis as a prognostic factor in selected categories of juvenile idiopathic arthritis [0.03%]
诊断年龄作为选择类幼年特发性关节炎的预后因素
Anna-Kaisa Tuomi,Katariina Rebane,Ellen Arnstad et al.
Anna-Kaisa Tuomi et al.
Introduction: The age at the onset of juvenile idiopathic arthritis (JIA) can influence the trajectory of the disease. We aimed to clarify how age at the visit 6 months after the onset as a continuous variable affects lon...
Unravelling VEXAS syndrome: shedding light on a recently recognised medical condition [0.03%]
解开VEXAS综合征之谜：一种新认识的医学状况不容小觑
Syeda Sarah Raza,Abdullah Ahmad Orakzai,Ahmed Salman et al.
Syeda Sarah Raza et al.
Despite advances, the prognosis remains guarded. However, individually tailored approaches and continued research will lead to improved outcomes.
Case Reports
BMJ case reports. 2025 Jun 10;18(6):e263248. DOI:10.1136/bcr-2024-263248 2025
Challenges in managing Stewart-Treves Syndrome: navigating complexities in recurrent lymphangiosarcoma [0.03%]
斯特沃兹综合征的管理挑战：反复出现的淋巴血管肉瘤的复杂性应对
Tanvi Rao,Joseph Thomas,Harshavardhan Kushal Shetty et al.
Tanvi Rao et al.
It is associated with poor prognosis due to its high risk of recurrence and metastasis.
Case Reports
BMJ case reports. 2025 Jun 10;18(6):e264152. DOI:10.1136/bcr-2024-264152 2025
Insights into retinoblastoma pathogenesis: unraveling RB1, N-MYC and miRNA profiles [0.03%]
视网膜母细胞瘤发病机制的见解：揭示RB1、N-MYC和miRNA谱型
Mohammad Faranoush,Fatemeh Khesali,Pooya Faranoush et al.
Mohammad Faranoush et al.
This study analyses gene expression and specific microRNAs (miRNAs) in patients with retinoblastoma to enhance early diagnosis, prognosis and treatment strategies.
Transcriptome-wide gene-age interaction study and multi-omics comprehensive analysis reveals heterogeneous regulation of NLRC4 during aging on HNSCC prognosis and immune microenvironment [0.03%]
转录组基因年龄交互作用研究及多组学综合分析揭示了NLRC4在衰老过程中对头颈部鳞癌预后和免疫微环境的异质性调控
Ziang Xu,Maojie Xue,Yuqing Yang et al.
Ziang Xu et al.
Subsequent transcriptome-wide NLRC4-age-based three-way interaction analysis reflected the broad association among NLRC4, age and ECM-related genes (mainly the collagen family) on the prognosis of HNSCC.
ZLY032 mediated activation of Notch1-Hes1 signaling inhibits cardiomyocyte ferroptosis to protect against myocardial Ischemia-Reperfusion injury in mice [0.03%]
ZLY032介导的Notch1-Hes1信号激活通过抑制心肌细胞铁死亡作用来保护小鼠心脏免受缺血/再灌注损伤
Hao-Dong Li,Dong-Ping Liu,Man-Yu Gong et al.
Hao-Dong Li et al.
Myocardial ischemia/reperfusion (I/R) injury seriously compromises patients' prognosis and survival rates. Accumulating evidence shows that ferroptosis is intricately involved in myocardial I/R injury. The activation of Notch1 exerts a protective effect on the heart.
Response to comment on "Low chronotropic response in post-myocardial infarction exercise test predicts worse prognosis in patients with preserved or mildly reduced left ventricular ejection fraction" [0.03%]
对“心肌梗死后运动试验低心率反应预测左室射血分数保留或轻度降低患者预后较差”的评论的回应
Krzysztof Smarz,Maciej Tysarowski
Krzysztof Smarz
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