TRPC6-targeted dexamethasone nanobubbles with ultrasound-guided theranostics for adriamycin-induced nephropathy [0.03%]
用于多柔比星致肾病的超声引导诊疗的特异性靶向TRPC6的糖皮质激素纳米气泡
Lin Wu,Yang Liu,Ziqi Fu et al.
Lin Wu et al.
Background: Glucocorticoid (GC) intolerance and systemic toxicity pose significant challenges in the treatment of primary nephrotic syndrome (PNS), underscoring the urgent need for targeted therapies that maximize efficac...
Systemic inflammation accelerates the development of focal segmental glomerulosclerosis in a mouse model of adriamycin induced nephrosis [0.03%]
系统性炎症加速阿霉素诱导的肾病小鼠模型中局灶节段性肾小球硬化的发展
Lian Liu,Qiu Li,Gaofu Zhang
Lian Liu
Research indicates that minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) may reflect varying severities of the same underlying condition, with inflammation potentially facilitating the progression from MCD to FSGS....
Brain peptides modified exosome-mediated drug delivery system for adriamycin-induced nephropathy treatment [0.03%]
脑肽修饰的外泌体介导的阿霉素肾病治疗递药系统
Lishan Tan,Huisong Zhou,Zhiwei Lai et al.
Lishan Tan et al.
Mitigation of adriamycin (ADR)-induced nephropathy remains a significant challenge in clinical management. Brain-targeted administration of losartan demonstrates comparable nephroprotective effects at a 1:500 concentration relative to gavag...
NAT10 mediates TLR2 to promote podocyte senescence in adriamycin-induced nephropathy [0.03%]
NAT10介导TLR2促进阿霉素诱导的肾病中足细胞衰老
Mingyang Hu,Linxiao Lv,Yuqi Lei et al.
Mingyang Hu et al.
N-acetyltransferase 10 (NAT10) is involved in regulating senescence. However, its role in glomerular diseases remains unclear. Therefore, this study aims to investigate the mechanisms by which NAT10 influences senescence and damage in an ad...
Nicotinamide ameliorates podocyte injury and albuminuria in adriamycin-induced nephropathy [0.03%]
烟酰胺改善了阿霉素诱导的肾病中的足细胞损伤和蛋白尿
Kei Takahashi,Emiko Sato,Seiko Yamakoshi et al.
Kei Takahashi et al.
Podocytes are key components of the glomerular filtration barrier, and their injury leads to proteinuria, chronic kidney disease (CKD), and nephrotic syndrome. Effective treatments for these conditions are not well established, and preventi...
SA4503 Mitigates Adriamycin-Induced Nephropathy via Sigma-1 Receptor in Animal and Cell-Based Models [0.03%]
SA4503通过Sigma-1受体在动物和细胞模型中减轻阿霉素诱导的肾病
Hideaki Tagashira,Shinsuke Chida,Md Shenuarin Bhuiyan et al.
Hideaki Tagashira et al.
Background/Objectives: The Sigma-1 receptor (Sigmar1), an intracellular chaperone protein, is ubiquitously expressed throughout the body, but its role in peripheral organs, such as the kidneys, remains unclear. Here, we investigated the pro...
Stem Cells Derived From Human Deciduous Exfoliated Teeth Ameliorate Adriamycin-Induced Nephropathy In Rats By Modulating The Th17/Treg Balance [0.03%]
人乳牙干细胞通过调节Th17/Treg平衡来改善阿霉素诱导的大鼠肾病
Yuyang Dai,Borui Tang,Xiuli Zhao
Yuyang Dai
Background: Idiopathic Nephrotic Syndrome (INS) is a common kidney disease in children, and the main clinical manifestations are hypoproteinaemia, proteinuria, hyperlipidaemia, and oedema. Mesenchymal Stem Cells (MSCs) ar...
CD73 alleviates podocytes injury in adriamycin-induced nephrotic syndrome [0.03%]
CD73缓解阿霉素诱导的肾病综合征中的足细胞损伤
Yanji Zhu,Guiling Xie,Fangyan Qi et al.
Yanji Zhu et al.
Podocyte injury is considered one of the main causes of kidney diseases occurrence and development. We have demonstrated that Ecto-5'-Nucleotidase (CD73) upregulated during podocyte injury, yet its function in podocyte is still unclear. Mou...
Protopanaxadiol synergizes with glucocorticoids to enhance the therapeutic effect in adriamycin-induced nephrotic syndrome [0.03%]
protopanaxadiol与糖皮质激素协同增效治疗阿霉素诱导的肾病综合征的效果
Ming-Yan Yang,Dong Qi,Meng-Ying Wang et al.
Ming-Yan Yang et al.
To date, glucocorticoids remain the mainstay of treatment of nephrotic syndrome (NS). However, serious side effects and development of drug-resistance following long-term use limit the application of glucocorticoids. Protopanaxadiol (PPD) p...
Renoprotective effects of Schoenoplectus tabernaemontani rhizomes aqueous extracts against Adriamycin-induced nephropathy in rats [0.03%]
水生节节草根茎提取物对阿霉素致大鼠肾损害的保护作用
Dian Peng,Juan Huang,Xiaohui Gao et al.
Dian Peng et al.
In recent years, chronic kidney disease (CKD) has emerged as an increasingly significant issue due to the growing prevalence and high treatment costs. While recorded the positive diuretic effect of Schoenoplectus tabernaemontani, there is a...
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