Copper-Catalyzed Stereoconvergent 1,4-Protosilylation of E/ Z Dienes [0.03%]
铜催化的E/Z共轭二烯烃的立体发散性1,4-亚硅基化反应
Longtao Huang,Yueyuan Wang,Min Gao et al.
Longtao Huang et al.
The conversion of E/Z isomeric olefin mixtures to a singular product is both significant and challenging. In this study, we present a copper-catalyzed stereoconvergent 1,4-protosilylation of E/Z conjugated diene mixtures, yielding allylic s...
Construction of 2,3-Naphthalimides through Cu-Catalyzed Decarboxylative Coupling between Arylpropiolic Acids and Isocyanides [0.03%]
通过Cu催化体系实现芳香丙烯酸与异氰化物的脱羧偶联反应合成喃妥霉素类化合物
Monty Kumar,Prashant Kumar,Ruchir Kant et al.
Monty Kumar et al.
Herein, we report a one-pot strategy to synthesize functionalized 2,3-naphthalimides by a copper-catalyzed coupling between arylpropiolic acids and isocyanides followed by a dehydro-Diels-Alder (DDA) reaction. The reaction proceeds through ...
Easy Access to α,β-Diamino-Substituted Cyclopentenaminones through Copper-Catalyzed Double Amination of Unactivated Cyclic Ketones [0.03%]
未活化环状酮的双重氨化合成α,β-二氨基取代环戊烯胺酮类化合物
Yihan Wang,Xiaojuan Yang,Zhiying Zhang et al.
Yihan Wang et al.
Here, we report a copper-catalyzed double amination of unactivated cyclic ketones with commercially available secondary arylamines for the synthesis of α,β-diamino-substituted cyclopentenaminones. The direct intermolecular C-N bond format...
Merging Paired Electrolysis and Copper Catalysis Enables Electrochemical Arylation of Aziridine for the Synthesis of 1,2-Amino Tertiary Alcohols [0.03%]
配对电解与铜催化的结合可实现氮杂环丙烷的电芳基化合成1,2-氨基三级醇
Zhong-Shan Teng,Yu-Rong Yang,Xin-Yu Zhang et al.
Zhong-Shan Teng et al.
1,2-Amino alcohols are omnipresent in bioactive molecules. Conventional approaches to this motif require multistep reactions. Herein, we develop an electrochemical strategy for copper-catalyzed convergent paired electrolysis. By selectively...
Le-Cheng Wang,Xiao-Feng Wu
Le-Cheng Wang
The catalytic conversion of carbon monoxide (CO) provides an enormous opportunity to construct carbonyl-containing molecules. Among them, the direct carbonylation of C-H bonds on gaseous hydrocarbon feedstocks provides a straightforward app...
Cu-Catalyzed Cycloaromatization and Amination of 2-Bromoaryl Nitriles, Terminal Alkynes, and Amines for 1-Aminoisoquinoline Synthesis [0.03%]
铜催化2-溴芳基腈，终端乙炔和胺的环芳香化和氨化合成1-氨基异喹啉化合物
Zhennan Lei,Saihong Wan,Feng Liu et al.
Zhennan Lei et al.
We report a copper-catalyzed 6-endo-dig cycloaromatization and amination of 2-bromoaryl nitriles, terminal alkynes, and amines for efficient and selective synthesis of 1-aminoisoquinolines, which involves difunctionalization of the cyano gr...
Copper-promoted late-stage glycosylsulfonylation of aryl iodide and bromide to access glycosyl aryl sulfones [0.03%]
铜催化的一碘苯和一溴苯的迟滞糖基磺酰化反应以得到糖基芳基砜类化合物
Linyitian Wang,Huize Guo,Jiaxin Luo et al.
Linyitian Wang et al.
Glycosyl aryl sulfones exhibit diverse biological activities. Herein, we developed a copper-promoted coupling strategy using glycosyl sodium sulfinates and aryl iodides or bromides, enabling efficient synthesis of carbohydrate-based sulfone...
Copper-Mediated Three-Component Reaction for the Synthesis of N-Sulfonylamidine on DNA [0.03%]
铜催化的三组分反应在DNA上合成N-磺酰胺亚胺类化合物
Tae Yeon Kwon,Yeonhee Lee,Kyung-Jin Cho et al.
Tae Yeon Kwon et al.
DNA-encoded library (DEL) technology is a transformative tool for identifying bioactive compounds in pharmaceutical research. This study presents an optimized copper-mediated reaction to synthesize N-sulfonylamidine derivatives from DNA-con...
Intramolecular Histidine Cross-Links Formed via Copper-Catalyzed Oxidation of Histatin Peptides [0.03%]
铜催化下组氨肽氧化形成的组氨酸分子内交联反应
Leah J Bontreger,Annastassia D Gallo,Jaewon Moon et al.
Leah J Bontreger et al.
Histidine is a versatile amino acid with metal-binding, nucleophilic, and basic properties that endow many peptides and proteins with biological activity. However, histidine itself is susceptible to oxidative modifications via post-translat...
Jun-Han Yu,Guo-Qiang Lin,Zhi-Tao He
Jun-Han Yu
Herein we describe the first transition-metal-catalyzed asymmetric Cloke-Wilson rearrangement through unprecedented propargylic alkenoxylation reaction with enol as the O-nucleophile. A set of new chiral PPBOX ligands was prepared to guaran...
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