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Muhammad Zain Raza,Huzaifa Fayyaz Khwaja,Hafiz Muhammad Ehsan Arshad et al. Muhammad Zain Raza et al.
Background and objectives: Ponatinib, a third-generation tyrosine kinase inhibitor (TKI), has shown efficacy in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), including cases with and without BCR...
Suraj S Vasanthi,Nyzil Massey,Christina Meyer et al. Suraj S Vasanthi et al.
Acute exposure to diisopropylfluorophosphate (DFP), an organophosphate nerve agent, induces status epilepticus (SE) and epileptogenesis despite treatment with countermeasures immediately after exposure. Epileptogenesis is characterized by i...
Yunhuan Liu,Yong Yu,Congli Hu et al. Yunhuan Liu et al.
Aim: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment approach for NSCLC. However, the effectiveness of ICI therapy in patients with EGFR-driven NSCLC, particularly those resistant to EGFR-TKI, has been disappointing. T...
Dilsher S Dhoot Dilsher S Dhoot
Purpose: To review current investigational strategies utilizing sustained delivery of VEGF receptor tyrosine kinase inhibitors (TKIs) for the treatment of retinal and choroidal vascular diseases. ...
Zhenfang Du,Hongfei Kan,Jinghan Sun et al. Zhenfang Du et al.
Tyrosine kinase inhibitors (TKIs) have revolutionized the management of epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). Despite the initially favorable outcomes, these patients inevitably acquire resistanc...
Zhe Tian,Lilan Cen,Feng Wei et al. Zhe Tian et al.
Mutations in EGFR (mEGFRs) in non-small cell lung cancer (NSCLC) are key factors driving tumor development and treatment response. The present article aimed to review the classification, characteristics and molecular mechanisms of resistanc...
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