HECLIP: Histology-Enhanced Contrastive Learning for Imputation of Transcriptomics Profiles [0.03%]
基于组织学增强对比学习的转录组谱系插补方法(HECLIP)
Qing Wang,Wen-Jie Chen,Jing Su et al.
Qing Wang et al.
Motivation: Histopathology, particularly hematoxylin and eosin (H&E) staining, is pivotal for diagnosing and characterizing pathological conditions by visualizing tissue morphology. However, H&E-stained images inherently ...
The Association Between Dexmedetomidine and Bradycardia: An Analysis of FDA Adverse Event Reporting System (FAERS) Data and Transcriptomic Profiles [0.03%]
度米芬与心动过缓的相关性：来自美国食品药品监督管理局不良事件报告系统（FAERS）数据和转录组谱型的分析
Robert Morris,Suguna Aishwarya Kuppa,Xinran Zhu et al.
Robert Morris et al.
Background/objectives: Bradycardia, an uncharacteristically low heart rate below 60 bpm, is a commonly reported adverse drug event (ADE) in individuals administered dexmedetomidine for sedation. Dexmedetomidine is frequen...
Transcriptomic profile of Lutraria sieboldii larvae: Insights into the molecular mechanisms of attachment and metamorphosis [0.03%]
施氏乳鼠尾虫幼虫转录组特征分析：附着和变态的分子机制初探
Taiyue Xu,Zhen Zhao,Jie Zou et al.
Taiyue Xu et al.
Metamorphosis, the crucial transition from planktonic to sessile life stages, marks a key developmental milestone in marine bivalves, particularly for commercially valuable species like Lutraria sieboldii. We conducted a comprehensive trans...
Transcriptomic Profiles of Rainbow Trout (Oncorhynchus mykiss) Selectively Bred for High and Low Fillet Yield [0.03%]
选育高肉质和低肉质的 rainbow trout 的转录组谱型分析
Jamie L Mankiewicz,Guangtu Gao,Timothy Leeds et al.
Jamie L Mankiewicz et al.
The fillet yield phenotype is a trait that can be improved in aquaculture species through conventional selective breeding. This approach was applied to rainbow trout for three consecutive generations of selection to produce a high-yield lin...
Transcriptomic profiling reveals RetS-mediated regulation of type VI secretion system and host cell responses in Pseudomonas aeruginosa infections [0.03%]
转录组谱分析揭示了铜绿假单胞菌感染中RetS介导的Ⅵ型分泌系统及宿主细胞反应调控机制
Yinglin Wu,Shan Huang,Kai Zhang et al.
Yinglin Wu et al.
Pseudomonas aeruginosa is a major opportunistic pathogen that causes chronic infections, particularly in patients with cystic fibrosis and chronic obstructive pulmonary disease (COPD). The type VI secretion system (T6SS) is a primary virule...
Molecular Subtypes of Balanopreputial and Urethral Male Genital Lichen Sclerosus: Distinct Transcriptomic and Clinicopathological Profiles [0.03%]
男性包皮和尿道硬化性苔藓的分子亚型：转录组和临床病理特征不同
Xianjie Xiu,Zhenwei Yu,Georgios Kravvas et al.
Xianjie Xiu et al.
Male genital lichen sclerosus (MGLSc) is a heterogeneous and aggressive disease characterized by varying severities of balanopreputial and urethral disease and outcomes, including stricture (MGLSc-US). This study aims to elucidate the trans...
Hippocampal transcriptome profiling associated with post-traumatic stress disorder-like behaviors in male mice [0.03%]
与小鼠 PTSD 样行为相关的海马转录组谱系分析
Zhen He,Yihan Qin,Guanbo Xie et al.
Zhen He et al.
Post-traumatic stress disorder (PTSD) is a trauma- and stressor-related disorder characterized by re-experiencing, avoidance of trauma-related stimuli, negative changes in mood and cognition, and hyperarousal. Despite its prevalence, the pa...
Aging induces T cells with distinct transcriptomic profiles and functions in brain-associated tissues [0.03%]
衰老诱导大脑相关组织中具有不同转录组特征和功能的T细胞
Youwen Si,Yuanyue Zhang,Qi Yang
Youwen Si
Background: Aging is known to induce the emergence of distinct lymphocyte populations with unique molecular and functional characteristics. However, the impact of aging on the transcriptomes and functional activities of C...
Transcriptomic profiles reveal DNA-dependent ATPase MbovRecD modulates Mycoplasma bovis survival through methyltransferase activity and carbohydrate metabolism regulation [0.03%]
转录组轮廓揭示DNA依赖性ATP酶MbovRecD通过甲基转移酶活性和碳水化合物代谢调节来调控牛支原体的存活
Xifang Zhu,Yajiao Li,Doukun Lu et al.
Xifang Zhu et al.
Mycoplasmas are host-restricted prokaryotes with nearly minimal genomes. Research on these microorganisms has been constrained by challenges in genetic manipulation and unclear gene functions. This study identified that mutation of MBOV_RS0...
Identification of Four Mechanisms for Per- and Polyfluoroalkyl Substances (PFAS) Through Transcriptomic Profiling from 24 PFAS-Exposed Human Liver Spheroids [0.03%]
通过转录组谱分析来自暴露于全氟和多氟烷基物质(PFAS)的人类肝脏类器官的四种PFAS作用机制
G C Addicks,A Rowan-Carroll,K Leingartner et al.
G C Addicks et al.
Per- and polyfluoroalkyl substances (PFAS) are persistent and widespread contaminants. Epidemiological effects of PFAS include increased serum cholesterol, decreased immune response to vaccination and disease, and increased incidence of can...
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