GABAergic signaling by VIP interneurons gates running-dependent visual recovery in the adult brain [0.03%]
视觉识别通路的成人脑神经元活动再塑视觉记忆形成
Anna Lebedeva,Friedrich Kling,Benjamin Rakela et al.
Anna Lebedeva et al.
Experience-dependent plasticity in the adult visual cortex is enhanced by locomotion, a process mediated by vasoactive intestinal peptide (VIP)-expressing interneurons. While VIP interneurons are known to signal through both Gamma-aminobuty...
Splenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8+ T cell priming and protective memory [0.03%]
脾脏成纤维细胞网状细胞调控树突状细胞成熟并促进CD8+T细胞活化和保护性免疫记忆形成
Yannick O Alexandre,Nikita Potemkin,Dominik Schienstock et al.
Yannick O Alexandre et al.
Fibroblastic reticular cells (FRCs) are specialized fibroblasts that construct secondary lymphoid organs where they provide crucial signals for immune cell homeostasis and migration. While splenic FRCs are thought to support antiviral T cel...
Diversity of clustered protocadherin-α genes in neuronal identity and its role in short-term specific associative memory formation [0.03%]
簇集原钙黏着蛋白-α基因的多样性在神经元身份和短期特异性联想记忆形成中的作用
Tomoki Osuka,Hiroki Yamamoto,Takeshi Yagi
Tomoki Osuka
Clustered protocadherins (cPcdh) are cell adhesion molecules with 58 isoforms, essential for neural circuit formation and higher cognitive functions. This study investigated the impact of reduced cPcdh-α diversity on cognitive function usi...
SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes [0.03%]
SFRS8通过调节突触基因的RNA剪接来调控记忆形成
Zeng Ding,Qiang Liu,Juan Zhang
Zeng Ding
SFRS8, a member of the serine and arginine-rich (SR) protein family, functions as a splicing factor and is highly expressed in the brain. Despite its abundance, its specific role in the brain has remained unclear. Here, we show that SFRS8 i...
Meprin β Modulates Brevican Proteolysis Impairing Neural Plasticity and Memory Formation [0.03%]
MEPRINβ通过调节神经可塑性和记忆形成的BREVCAN蛋白水解发挥作用
Maximilian Keller,Celine Gallagher,Simon Kreiselmaier et al.
Maximilian Keller et al.
The metalloprotease meprin β is known for its multifunctional involvement in various physiological processes throughout the body including the brain. However, its broader functions within the brain besides amyloid β generation remain larg...
Dae-Si Kang,Ja Wook Koo
Dae-Si Kang
Fear memory formation is crucial for survival, with the hippocampus playing a central role. This study investigates the behavioral and molecular aspects of fear memory formation, focusing on Dual-specificity tyrosine phosphorylation-regulat...
Malonate promotes CD8+ T cell memory formation via protein malonylation [0.03%]
丙二酸通过蛋白质琥珀酰化促进CD8⁺T细胞记忆的形成
Qianqian Duan,Jiajia Wang,Liang Sun et al.
Qianqian Duan et al.
Protein malonylation represents a recently identified posttranslational modification whose role in CD8+ T cell differentiation and functionality remains incompletely understood. In this study, we demonstrate that enhancing protein malonylat...
Subcortical nuclei of the human ascending arousal system encode anticipated reward but do not predict subsequent memory [0.03%]
人类觉醒系统的皮层下核体编码预期奖赏但不能预测随后的记忆形成
Beth Lloyd,Steven Miletić,Pierre-Louis Bazin et al.
Beth Lloyd et al.
Subcortical nuclei of the ascending arousal system (AAS) play an important role in regulating brain and cognition. However, functional MRI (fMRI) of these nuclei in humans involves unique challenges due to their size and location deep withi...
Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory [0.03%]
组蛋白乳酸化修饰连接代谢和表观遗传重编程促进先天免疫记忆形成
Athanasios Ziogas,Boris Novakovic,Lorenzo Ventriglia et al.
Athanasios Ziogas et al.
Trained immunity, a de facto innate immune memory characterized by enhanced responsiveness to future challenges, is underpinned by epigenetic and metabolic rewiring. In individuals vaccinated with Bacille Calmette-Guérin (BCG), lactate rel...
Motor learning is regulated by postnatal GDNF levels in Purkinje cells [0.03%]
新皮层GDNF通过调节星形胶质细胞功能调控突触可塑性和记忆形成
Elina Nagaeva,Giorgio Turconi,Kärt Mätlik et al.
Elina Nagaeva et al.
Purkinje cells (PCs), the sole output neurons of the cerebellar cortex, are crucial for cerebellum-dependent motor learning. In cerebellar ataxia, reduction in motor function and learning associates with decreased spontaneous activity of PC...
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