Ruiyang Zhao,Bo Cao,Hanghang Li et al. Ruiyang Zhao et al.

A fasting mimic diet (FMD) has been proven to be a potential therapeutic regimen for gastric cancer (GC) patients. However, the intolerance of energy restriction and limited efficacies hinder wide application of FMD. To identify critical ta...

Mengsi Zhang,Hao Zheng,Xuanqi Zhu et al. Mengsi Zhang et al.

Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation on the cystine transporter solute carrier family 7 member 11/g...

Jieru Zhang,Ruxia Li,Luyong Wang et al. Jieru Zhang et al.

Nan Zhang,Lu Dong,Sifan Liu et al. Nan Zhang et al.

Background: Mitochondrial dynamics are essential for maintaining cellular function under metabolic stress. However, their role in colon cancer's response to glucose deprivation remains poorly understood. ...

Ivan L Salazar,Michele Curcio,Miranda Mele et al. Ivan L Salazar et al.

Neuronal damage in brain ischemia is characterized by a disassembly of the proteasome and a decrease in its proteolytic activity. However, to what extent these alterations are coupled to neuronal death is controversial since proteasome inhi...

Olivia R Buonarati,Nidia Quillinan,K Ulrich Bayer Olivia R Buonarati

Learning and memory are thought to require hippocampal long-term potentiation (LTP), a form of synaptic plasticity that is persistently impaired after cerebral ischemia and that requires movement of the Ca 2+ /calmodulin-dependent protein k...

Sara Amiranda,Mariangela Succoio,Serenella Anzilotti et al. Sara Amiranda et al.

Carbonic anhydrases constitute a family of metalloenzymes vital for maintaining acid-base balance and regulating pH in physio-pathological processes. These findings suggest carbonic anhydrases as potential therapeutic targets for treating p...

G Gokulapriya,B S Lakshmi G Gokulapriya

Extracellular signal-regulated kinases (ERKs) belong to the family of mitogen-activated protein kinases and transmit extracellular signals. The present study investigates ERK-mediated control of ATG3 and ATG5 as an adaptive response to glut...

Jieru Zhang,Ruxia Li,Luyong Wang et al. Jieru Zhang et al.

Accumulating studies have unraveled that dexmedetomidine (DEX) is neuroprotective against brain damage. However, it remains largely unknown about the mechanism involved in the neuroprotective effect of DEX. Therefore, this study explored wh...

María Torres-López,Patricia González-Rodríguez,Olalla Colinas et al. María Torres-López et al.

The carotid body (CB) is the main oxygen (O2) sensing organ that mediates reflex hyperventilation and increased cardiac output in response to hypoxaemia. Acute O2 sensing is an intrinsic property of CB glomus cells, which contain special mi...