Rui Zhang,Keita Kanki Rui Zhang

Decreased cell viability resulting from severe nutrient deprivation is a major obstacle in three-dimensional (3D) tissue construction. Therefore, technical improvements that prevent cell death in the core region of cell aggregates are desir...

Zhiyu Qian,Xinyue Zhang,Jiahua Huang et al. Zhiyu Qian et al.

Renal ischemia-reperfusion injury (IRI), a common complication following kidney transplantation and partial nephrectomy, is the leading cause of renal dysfunction with limited treatment. Excessive cellular iron accumulation drives lipid per...

Francisco Gallardo-Chamizo,Román González-Prieto,Vahid Jafari et al. Francisco Gallardo-Chamizo et al.

Because limited oxygen and glucose supply to tissues is a serious challenge that cells must properly measure to decide between surviving or triggering cell death, organisms have developed accurate mechanisms for sensing and signaling these ...

Yiyin Zhao,Xiaojing Zhou,Songbin He et al. Yiyin Zhao et al.

Stroke is the leading cause of death and disability worldwide, and the mechanisms of stroke onset have not been fully elucidated. The research investigated how actin remodeling functions within brain microvascular endothelial cells (bEnd.3 ...

Kohei Aoyama,Kaori Yoriki,Kota Aoki et al. Kohei Aoyama et al.

Cisplatin resistance poses a substantial barrier to the successful treatment of advanced endometrial cancer. Glucose deprivation in the tumor microenvironment, resulting from inadequate vascularization and rapid proliferation of cancer cell...

Flávia Santos Sanches,Florisvaldo da Silva Ramos,Cinthia Cristina de O S Costa et al. Flávia Santos Sanches et al.

Amburana cearensis is a plant native to Brazil used in folk medicine for the treatment of several pathological conditions including stroke. Previous research indicates that a dichloromethane extract of A. cearensis seeds (EDAC), rich in cou...

Agathe Dubuisson,Adèle Mangelinck,Samantha Knockaert et al. Agathe Dubuisson et al.

Background: The ability of immune cells to rapidly respond to pathogens or malignant cells is tightly linked to metabolic pathways. In cancer, the tumor microenvironment (TME) represents a complex system with a strong met...

Ruiyang Zhao,Bo Cao,Hanghang Li et al. Ruiyang Zhao et al.

A fasting mimic diet (FMD) has been proven to be a potential therapeutic regimen for gastric cancer (GC) patients. However, the intolerance of energy restriction and limited efficacies hinder wide application of FMD. To identify critical ta...

Mengsi Zhang,Hao Zheng,Xuanqi Zhu et al. Mengsi Zhang et al.

Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation on the cystine transporter solute carrier family 7 member 11/g...

Jieru Zhang,Ruxia Li,Luyong Wang et al. Jieru Zhang et al.