Hypomagnesemia induces impaired glucose metabolism and insulin resistance in patients with Gitelman syndrome [0.03%]
低镁血症可引起格特曼综合征患者的葡萄糖代谢障碍和胰岛素抵抗
Yu Xin,Yaqi Yin,Lili Zhu et al.
Yu Xin et al.
Aims: To investigate the contributing factors of impaired glucose metabolism in patients with Gitelman syndrome (GS). Methods: This stu...
Liangjing Chen,Chunyu Wang,Lixia Qin et al.
Liangjing Chen et al.
Parkinson's disease (PD) is the second most common neurodegenerative disorder. PD patients exhibit varying degrees of abnormal glucose metabolism throughout disease stages. Abnormal glucose metabolism is closely linked to the PD pathogenesi...
Fanhao Meng,Jing Wang,Long Wang et al.
Fanhao Meng et al.
Major depressive disorder (MDD) is a common mental disorder with chronic tendencies that seriously affect regular work, life, and study. However, its exact pathogenesis remains unclear. Patients with MDD experience systemic and localized im...
Impaired brain glucose metabolism as a biomarker for evaluation of dodecyl creatine ester in creatine transporter deficiency: Insights from patient brain-derived organoids and in vivo [18F]FDG PET imaging in a mouse model [0.03%]
脑葡萄糖代谢障碍作为肉毒碱转运蛋白缺乏症中十二烷基肉毒碱酯评价生物标志物的证据：来自患者脑源性类器官和小鼠模型体内[18F]FDG正电子发射断层扫描成像的启示
Clémence Disdier,Amélie Soyer,Léa Broca-Brisson et al.
Clémence Disdier et al.
Creatine transporter deficiency (CTD) is an inborn error of creatine (Cr) metabolism in which Cr is not properly distributed to the brain due to a mutation in the Cr transporter (CrT) SLC6A8 gene. CTD is associated with developmental delays...
Dantrolene paradoxically exacerbates short-term brain glucose hypometabolism, hippocampal damage and neuroinflammation induced by status epilepticus in the rat lithium-pilocarpine model [0.03%]
丹曲林通过加剧锂-匹莫卡aine模型中持续性癫痫发作诱发的大鼠短期脑葡萄糖代谢障碍、海马损伤及神经炎症而产生反作用
Luis García-García,Francisca Gómez-Oliver,Rubén Fernández de la Rosa et al.
Luis García-García et al.
Status epilepticus (SE) is a neurologic emergency characterized by prolonged or rapidly recurring seizures. Increased intracellular calcium concentration ([Ca2+]i) occurring after SE is a key mediator of excitotoxicity that contributes to t...
Glucose metabolism impairment as a hallmark of progressive myoclonus epilepsies: a focus on neuronal ceroid lipofuscinoses [0.03%]
糖代谢紊乱是进行性肌阵挛癫痫的标志：以神经元 ceroid 激脂osis 为例
Lorenzo Santucci,Sara Bernardi,Rachele Vivarelli et al.
Lorenzo Santucci et al.
Glucose is the brain's main fuel source, used in both energy and molecular production. Impaired glucose metabolism is associated with adult and pediatric neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),...
Single-Atom Ce-N-C Nanozyme Ameliorates Type 2 Diabetes Mellitus by Improving Glucose Metabolism Disorders and Reducing Oxidative Stress [0.03%]
单原子Ce-N-C纳米酶通过改善葡萄糖代谢紊乱和降低氧化应激来缓解2型糖尿病 mellitus
Yitong Lin,Yanan Wang,Qi Zhang et al.
Yitong Lin et al.
Type 2 diabetes mellitus (T2DM) as a chronic metabolic disease has become a global public health problem. Insulin resistance (IR) is the main pathogenesis of T2DM. Oxidative stress refers to an imbalance between free radical production and ...
Impaired Glucose Metabolism, Primary Cilium Defects, and Kidney Cystogenesis in Glycogen Storage Disease Type Ia [0.03%]
I型糖原贮积病患者的葡萄糖代谢障碍、纤毛缺陷和肾脏囊性病变
Laure Monteillet,Gwendoline Perrot,Félicie Evrard et al.
Laure Monteillet et al.
Key Points: Metabolism adaptations due to glucose-6 phosphate accumulation in glycogen storage disease type Ia kidneys, toward a Warburg-like metabolism, promoted cell proliferation.Metabolic perturbations directly affec...
Modulation of brain energy metabolism in hepatic encephalopathy: impact of glucose metabolic dysfunction [0.03%]
肝性脑病中大脑能量代谢的调节：葡萄糖代谢障碍的影响
Shambhu Kumar Prasad,Arup Acharjee,Vishal Vikram Singh et al.
Shambhu Kumar Prasad et al.
Cerebral function is linked to a high level of metabolic activity and relies on glucose as its primary energy source. Glucose aids in the maintenance of physiological brain activities; as a result, a disruption in metabolism has a significa...
Glucose metabolism disorder related to follicular fluid exosomal miR-122-5p in cumulus cells of endometriosis patients [0.03%]
子宫内膜异位症患者卵泡液中cumulus细胞来源的外泌体miR-122-5p参与糖代谢异常的研究
Jingyi Zhang,Kaiquan Li,Liusijie Gao et al.
Jingyi Zhang et al.
In brief: Elevated expression of miR-122-5p in exosomes in the follicular fluid of patients with endometriosis impairs glucose metabolism in cumulus cells and may further impair oocyte quality. ...
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