Core Flipping in Lead Optimization: Rank Ordering Using λ-Dynamics [0.03%]
核心翻转在药物优化中的作用：使用λ-动力学排序分析
Parveen Gartan,Charles L Brooks rd,Nathalie Reuter
Parveen Gartan
In structure-based drug discovery, reliable structural models of ligands bound to their target receptors are critical for establishing the structure-activity relationship of the congeneric series. In such a series, substitutions on a common...
Design, synthesis and structure-activity relationship studies of novel macrocyclic 2,4-diaminopyrimidines as HPK1 inhibitors [0.03%]
新型环状鸟苷酸环化酶（HCN）通道激动剂的发现及基于配体和结构的药物优化研究
Feifei Wu,Jiaqi Sun,Mingyang Xu et al.
Feifei Wu et al.
Hematopoietic progenitor kinase 1 (HPK1) functions as a key negative regulator of T cell receptor signaling and has been considered a potential target for cancer immunotherapy. Despite great progress in developing HPK1 inhibitors, no small-...
Impact of immediate drug optimization of ustekinumab on medium term targets in Crohn's disease: results from the multicentre retrospective real-life study MUST [0.03%]
乌司奴单抗起始治疗即刻药物优化对中重度克罗恩病患者近期疗效影响的多中心回顾性研究（MUST研究）
M Hupé,A Abdelmoula,T Chateau et al.
M Hupé et al.
Background and aim: Whether immediate drug dose intensification is a valuable option to optimize ustekinumab efficacy in Crohn's disease (CD) remains unknown. We compared the one-year efficacy of immediate optimisation of...
Optimizing Treatment for Depression in Primary Care Using Psychotherapy Versus Antidepressant Medication in a Low-Resource Setting: Protocol for the OptimizeD Randomized Controlled Trial [0.03%]
在低资源环境中使用心理治疗与抗抑郁药物优化初级保健中抑郁症治疗的方案：OptimizeD 随机对照试验方案
Julia R Pozuelo,Anuja Lahiri,Rahul S P Singh et al.
Julia R Pozuelo et al.
Background: Psychotherapy and antidepressant medications are first-line treatments for depression, and they both have significant treatment effects on average. However, treatment response varies widely across patients, and neither approach ...
Teaching routine person-centred practice in medical education through medicines optimisation: A realist review [0.03%]
基于药物优化的医学教育中教学常规以人为本实践的真实主义回顾
Richard Bodington,Joanne Reeve,David Hepburn et al.
Richard Bodington et al.
Background: Multimorbid patients are not well served by a narrow biomedical disease-focused approach to health care. The situation calls for a paradigm shift in health care practice towards an interpretive, person-centred...
Optimizing Antibiotic use and Awareness in Hospitals: Establishing Effective Antimicrobial Stewardship Pathways [0.03%]
医院抗菌药物优化使用与管理认知：建立有效的抗菌药物管理工作路径
Bianca Maria Donida,Grazia Mingolla,Antonio Manfredi
Bianca Maria Donida
Background: Antibiotic resistance poses a significant challenge in healthcare, requiring effective management of antibiotic use. This study examines systemic antibiotic consumption at ASST Bergamo Ovest, a northern Italia...
Impact of the deprescribing timing on medicines optimisation in older cancer patients receiving hospice care at the end of life: a comparative cohort study [0.03%]
终止用药时间对老年癌症临终关怀病人药物优化的影响：一项比较队列研究
Tahani Alwidyan,Omar Shamieh,Carole Parsons et al.
Tahani Alwidyan et al.
Background: Deprescribing, the systematic discontinuation of potentially inappropriate medications, is essential for optimising end-of-life care in older cancer patients, particularly in hospice settings. While the benefi...
Is It Safe to Initiate/Optimize the Medication of HFrEF Patients During Hospitalization for Acute Decompensation? [0.03%]
HFrEF患者急性失代偿住院期间开始/优化药物治疗的安全性如何？
Ruxandra Maria Christodorescu,Daniel Miron Brie,Alina Diduța Brie et al.
Ruxandra Maria Christodorescu et al.
Background: Current guidelines emphasize the importance of initiating or optimizing the four pillars of heart failure with reduced ejection fraction (HFrEF) therapy-beta-blockers (BB), mineralocorticoid receptor antagonists (MRA), angiotens...
Research on the optimization model of anti-breast cancer candidate drugs based on machine learning [0.03%]
基于机器学习的抗乳腺癌候选药物优化模型研究
Zhou Dong,Hong Chen,Yuchen Yang et al.
Zhou Dong et al.
Breast cancer is one of the most common malignancies among women globally, with its incidence rate continuously increasing, posing a serious threat to women's health. Although current treatments, such as drugs targeting estrogen receptor al...
Advancing Monoclonal Antibody Manufacturing: Process Optimization, Cost Reduction Strategies, and Emerging Technologies [0.03%]
抗体药物优化生产工艺及成本控制策略研究进展
Ranjit Ranbhor
Ranjit Ranbhor
Purpose: This review examines recent advances in monoclonal antibody (mAb) manufacturing, focusing on process optimization, cost reduction strategies, and emerging technologies. The analysis addresses critical challenges ...
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