Predictive Modeling of Pharmacokinetic Drug-Drug and Herb-Drug Interactions in Oncology: Insights From PBPK Studies [0.03%]
基于PBPK研究的肿瘤学药代动力学药物相互作用和中西药相互作用的预测模型及其启示
Enes Emre Taş,Kutlu O Ulgen
Enes Emre Taş
Physiologically based pharmacokinetic (PBPK) modeling is increasingly used to anticipate, quantify, and strategically manage drug-drug (DDI) and herb-drug (HDI) interactions that can alter the exposure of chemotherapy agents together with c...
Pharmacokinetics Screening, Molecular Docking, and Dynamics Simulations Revealed Novel Antimicrobial Peptide NKLF2 Mutants as Potent Inhibitors of Mycobacterium tuberculosis [0.03%]
药代动力学筛选、分子对接和动态模拟揭示了新型抗菌肽NKLF2突变体可有效抑制结核分枝杆菌
Elizabeth Annie George,Aniket Naha,H Soundharya et al.
Elizabeth Annie George et al.
The increasing threat of multidrug-resistant Mycobacterium tuberculosis (Mtb) underscores the urgent need for novel therapeutics that can circumvent existing resistance mechanisms. The clinical ineffectiveness of current treatment regimens ...
Advancing the development of deep learning and machine learning models for oral drugs through diverse descriptor classes: a focus on pharmacokinetic parameters (Vdss and PPB) [0.03%]
通过多种描述符类推进口服药物的深度学习和机器学习模型的发展：着重于药代动力学参数（Vdss 和 PPB）
Rakesh Bantu,Samiron Phukan,Simon Haydar
Rakesh Bantu
In the present study, we report a predictive deep learning (DL) and machine learning (ML) model for pharmacokinetics (PK) parameters such as volume of distribution (Vdss) and plasma protein Binding (PPB). Using DL & ML algorithms our study ...
Characterization of preclinical radio ADME properties of ARV-471 for predicting human PK using PBPK modeling [0.03%]
基于PBPK模型预测ARV-471人体PK的临床前放射性ADME特性研究
Yifei He,Chenggu Zhu,Peng Lei et al.
Yifei He et al.
Proteolysis-targeting chimeras (PROTACs) represent a promising class of drugs that can target disease-causing proteins more effectively than traditional small molecule inhibitors can, potentially revolutionizing drug discovery and treatment...
Clozapine plasma level toxicity induced by a pharmacokinetic interaction with bupropion: A case report [0.03%]
布普品的药动学相互作用引起的氯氮平血浆浓度毒性一例报告
Kelly N Gable,Jaron Asher
Kelly N Gable
Introduction: Clozapine is the gold-standard antipsychotic treatment for patients with treatment-resistant schizophrenia. Prescribers must be vigilant in ensuring that all risk evaluation mitigation strategies requirement...
Pharmacokinetics, Excretion, and Organ Distribution of the Novel Gadolinium-Based MRI Contrast Agent Gadoquatrane in Female Cynomolgus Monkeys [0.03%]
新型Gd基MRI对比剂Gadoquatrane在雌性猕猴体内的药代动力学、排泄及器官分布研究
Clemens Guenther,Thomas Frenzel,Antje Rottmann et al.
Clemens Guenther et al.
Objectives: Gadoquatrane is a tetrameric, macrocyclic, extracellular gadolinium-based MRI contrast agent with high relaxivity and stability, which is currently in Phase 3 clinical development. The aim of the present study...
Pharmacokinetic analysis of carboplatin and fluorescein brain retention following ultrasound-based blood-brain barrier opening [0.03%]
基于超声波的血脑屏障打开后卡铂和荧光素的药代动力学分析及大脑滞留量研究
Karl J Habashy,Timothy W Synold,Ye Feng et al.
Karl J Habashy et al.
Background: The blood-brain barrier (BBB) impedes the passage of most circulating drugs into the brain. Low-intensity pulsed ultrasound with microbubbles (LIPU/MB) transiently opens the BBB, improving parenchymal drug pen...
Population pharmacokinetic and exposure-response study of a novel anti-tuberculosis drug to inform its dosage design in phase III clinical trial [0.03%]
一种新型抗结核药物的群体药代动力学及暴露-效应关系研究为其三期临床试验给药剂量设计提供依据
Weijie Kong,Hao Liang,Yi Zhang et al.
Weijie Kong et al.
Although bedaquiline (BDQ) received conditional approval for multi-drug resistance tuberculosis (MDR-TB), a black box warning was added due to QT prolongation risk. WX-081, a promising second-in-class drug that finished phase II clinical tr...
Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling [0.03%]
全氟和多氟化合物与大鼠肝脏及血清蛋白结合：基于生理的药代动力学模型的意义
Xiarui Fan,Xiaomin Li,Tong Li et al.
Xiarui Fan et al.
Understanding the binding between per- and polyfluoroalkyl substances (PFAS) and proteins is essential for elucidating their toxicokinetics and tissue distribution. Here, we quantified the binding affinities of 14 PFAS to rat liver fatty ac...
Evaluation of pharmacokinetics of intravenous protein C concentrate in protein C deficiency: implications for treatment initiation and maintenance [0.03%]
评估蛋白C缺乏症患者静脉注射蛋白C浓缩剂的药代动力学：对治疗启动和维持的启示
Zhaoyang Li,Inmaculada C Sorribes,Jennifer Schneider et al.
Zhaoyang Li et al.
Background: Dosing of intravenous protein C concentrate (Ceprotin) in patients with protein C deficiency is guided by pharmacokinetics (PK) of plasma protein C activity. ...
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