Tumour-associated macrophage infiltration differs in meningioma genotypes, and is important in tumour dynamics [0.03%]
肿瘤相关巨噬细胞在脑膜瘤基因型中的浸润差异及其在肿瘤动态发展中的重要性
Ting Zhang,Claire L Adams,Gyorgy Fejer et al.
Ting Zhang et al.
Background: Meningiomas are the most common primary intracranial tumours, with clinical behaviours ranging from benign to highly aggressive forms. The World Health Organisation classifies meningiomas into various grades, ...
Novel germline and somatic variants in familial and sporadic meningioma genes [0.03%]
家族性和散发性脑膜瘤的新型胚系和体细胞变异基因
Bouchra Ouled Amar Bencheikh,Allison A Dilliott,Julie Gauthier et al.
Bouchra Ouled Amar Bencheikh et al.
Meningiomas arise from arachnoid cells in the meninges surrounding the brain and spinal cord and are attributed to NF2 pathogenic variants in, approximately 60% of cases. Using exome sequencing, we found heterozygous germline variants in ni...
The FGF6 amplification mutation plays an important role in the progression and treatment of malignant meningioma [0.03%]
FGF6扩增突变在恶性脑膜瘤进展和治疗中起重要作用
Ruihao Liang,Binhua Tan,Kai Lei et al.
Ruihao Liang et al.
Meningioma is a benign tumor with slow growth and long course. However, patients with recurrent malignant meningioma still face a lack of effective treatment. Here, we report a rare case of primary mediastinal malignant meningioma with lung...
Unveiling a Biomarker Signature of Meningioma: The Need for a Panel of Genomic, Epigenetic, Proteomic, and RNA Biomarkers to Advance Diagnosis and Prognosis [0.03%]
揭开脑膜瘤生物标志物特征的面纱：推进诊断和预后所需的基因组、表观遗传学、蛋白质组和RNA生物标志物谱系
Reem Halabi,Fatima Dakroub,Mohammad Z Haider et al.
Reem Halabi et al.
Meningiomas are the most prevalent primary intracranial tumors. The majority are benign but can undergo dedifferentiation into advanced grades classified by World Health Organization (WHO) into Grades 1 to 3. Meningiomas' tremendous variabi...
Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas [0.03%]
NF2突变的幕上和幕下脑膜瘤的临床和基因组差异
Joanna K Tabor,Joseph O&#x;Brien,Sagar Vasandani et al.
Joanna K Tabor et al.
Objective: Mutations in NF2 are the most common somatic driver mutation in sporadic meningiomas. NF2 mutant meningiomas preferentially arise along the cerebral convexities-however, they can also be found in the posterior ...
Charbel Moussalem,Elie Massaad,Georges B Minassian et al.
Charbel Moussalem et al.
Meningiomas are amongst the most commonly encountered intracranial tumors. The majority of these tumors arise intracranially, and the remaining incidents occur along the spinal cord. Meningiomas tend to grow gradually, with many tumors aris...
Advances in meningioma genomics, proteomics, and epigenetics: insights into biomarker identification and targeted therapies [0.03%]
脑膜瘤基因组学、蛋白质组学和表观遗传学的新进展：生物标志物识别与靶向治疗新见解
Ahmad A Nazem,Jacob Ruzevick,Manuel J Ferreira Jr
Ahmad A Nazem
Meningiomas are a heterogeneous group of tumors, defined histo-pathologically by World Health Organization (WHO) grading. The WHO grade of meningiomas does not always correlate with clinical aggressiveness. Despite maximal surgical resectio...
High Copy-Number Variation Burdens in Cranial Meningiomas From Patients With Diverse Clinical Phenotypes Characterized by Hot Genomic Structure Changes [0.03%]
具有不同临床表型的颅内脑膜瘤中的高拷贝数变异负担及其热基因组结构变化特征
Junpeng Ma,Yaqiang Hong,Wei Chen et al.
Junpeng Ma et al.
Meningiomas, as the most common primary tumor of the central nervous system, are known to harbor genomic aberrations that associate with clinical phenotypes. Here we performed genome-wide genotyping for cranial meningiomas in 383 Chinese pa...
Ocular coloboma: Genetic variants reveal a dynamic model of eye development [0.03%]
眼部脑膜瘤：基因变异揭示了眼睛发育的动态模型
Kevin H Yoon,Sabrina C Fox,Renée Dicipulo et al.
Kevin H Yoon et al.
Ocular coloboma is a congenital disorder of the eye where a gap exists in the inferior retina, lens, iris, or optic nerve tissue. With a prevalence of 2-19 per 100,000 live births, coloboma, and microphthalmia, an associated ocular disorder...
Multiple Pulmonary and Pleural Metastases in Recurrent Intracranial Meningioma with Genetic Changes: Case Report and Review of the Literature [0.03%]
伴有遗传改变的复发性脑内脑膜瘤伴肺和胸膜转移的病例报道及文献复习
Ningning He,Liqiang Zhong,Kaijian Lei
Ningning He
Background: According to the 2016 World Health Organization classification of central nervous system tumors, meningiomas are classified into 3 grades: I, II, and III. It has been reported that 2%-10% of meningiomas exhibi...
Case Reports
World neurosurgery. 2020 Apr:136:337-340. DOI:10.1016/j.wneu.2020.01.060 2020
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