Tetramethylpyrazine enhances neuroprotection and plasticity in cerebral ischemia-reperfusion injury via RhoA/ROCK2 pathway inhibition [0.03%]
tetramethylpyrazine通过抑制RhoA/ROCK2通路增强脑缺血再灌注损伤中的神经保护和可塑性
Yixin Zhang,Xin Zhang,Xiaocheng Shi et al.
Yixin Zhang et al.
Tetramethylpyrazine (TMP) is an active component of the Chuanxiong, effectively crosses blood-brain barrier (BBB). It exhibits neuroprotective potential in cerebral ischemia-reperfusion injury (CIRI). This study performed middle cerebral ar...
Beta-asarone alleviated cerebral ischemia/reperfusion injury by targeting PINK1/Parkin-dependent mitophagy [0.03%]
β-asarone通过靶向PINK1/Parkin依赖的线粒体自噬缓解脑缺血/再灌注损伤
Yujiao Wang,Daojun Xie,Shijia Ma et al.
Yujiao Wang et al.
Cerebral ischemia-reperfusion injury (CIRI) describes a secondary type of brain damage that happens when blood flow is restored to brain tissue; it ranks among the primary contributors of disability and mortality. The activation of PINK1/Pa...
Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress [0.03%]
神经丝蛋白通过抑制缺血诱导的内质网应激缓解脑缺血再灌注损伤
Yumei Liao,Qinghua Zhang,Qiaoyun Shi et al.
Yumei Liao et al.
JOURNAL/nrgr/04.03/01300535-202601000-00037/figure1/v/2025-06-09T151831Z/r/image-tiff Neuroserpin, a secreted protein that belongs to the serpin superfamily of serine protease inhibitors, is highly expressed in the central nervous system an...
Mangiferin mitigates neurological deficits and ferroptosis via NRF2/ARE pathway activation in cerebral ischemia-reperfusion rats [0.03%]
芒果苷通过激活NRF2/ARE通路缓解脑缺血再灌注损伤大鼠神经功能缺损和铁死亡
Chenjia Peng,Yang Zhang,Jiaqing Chai et al.
Chenjia Peng et al.
Introduction: Ferroptosis is a newly described form of nonapoptotic, iron-dependent cell death that plays an essential role in the pathogenesis of ischemic stroke. Targeting ferroptosis may be an effective way to treat is...
Expression of concern: "Hyperbaric oxygen preconditioning induces tolerance against brain ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats" [BRAIN RES, Volume 1210 (2008) 223-229] [0.03%]
表达关切：“高压氧预处理通过上调抗氧化酶诱导对脑缺血再灌注损伤的耐受性”[BRAIN RES,Volume1210(2008)223-229]
Jiasi Li,Wenwu Liu,Suju Ding et al.
Jiasi Li et al.
A polymerized probucol nanoformulation with neutrophil extracellular vesicle camouflage for cerebral ischemia-reperfusion injury therapy [0.03%]
一种伪装成中性粒细胞外囊泡的聚多布克隆纳米制剂用于脑缺血再灌注损伤治疗
Mengjie Jia,Wenjun Miao,Yiliang Li et al.
Mengjie Jia et al.
This study leverages the unique advantages of polyprodrug systems and biomimetic technology to develop a novel biomimetic nanoformulation, in which neutrophil extracellular vesicles (NEVs) are coated onto reactive oxygen species (ROS)-sensi...
The Role of Formononetin in Cerebral Ischemia-Reperfusion Injury: A New Mediator of c-Fos/IL-10/STAT3 Signaling Pathway [0.03%]
染料木素通过调节c-Fos/IL-10/STAT3信号通路参与缺血再灌注脑损伤中的作用研究
Ming Yan,Fuyong Ni,Xue Xie et al.
Ming Yan et al.
Backgrounds: Inflammation plays a pivotal role in the advancement of ischemic stroke, and Formononetin has been recognized for its potential benefits due to its anti-inflammatory effects. Although Formononetin shows promi...
Emodin influences pyroptosis-related Caspase 1-GSDMD axis alleviated cerebral ischemia-reperfusion injury in rats [0.03%]
大黄酚通过影响焦亡相关Caspase 1-GSDMD轴改善大鼠脑缺血再灌注损伤
Guofang Zhang,Xiaolin Hu,Jun Qian et al.
Guofang Zhang et al.
Cerebrovascular diseases, particularly ischemic stroke, are a leading cause of global disability. Effective management of ischemia-reperfusion injury is crucial in stroke treatment. Emodin, known for its anti-inflammatory and neuroprotectiv...
[Study on mechanism of naringin in alleviating cerebral ischemia/reperfusion injury based on DRP1/LRRK2/MCU axis] [0.03%]
基于DRP1/LRRK2/MCU轴的柚皮素改善脑缺血再灌注损伤机制研究
Kai-Mei Tan,Hong-Yu Zeng,Feng Qiu et al.
Kai-Mei Tan et al.
This study aims to investigate the molecular mechanism by which naringin alleviates cerebral ischemia/reperfusion(CI/R) injury through DRP1/LRRK2/MCU signaling axis. A total of 60 SD rats were randomly divided into the sham group, the model...
[Polysaccharide extract PCP1 from Polygonatum cyrtonema ameliorates cerebral ischemia-reperfusion injury in rats by inhibiting TLR4/NLRP3 pathway] [0.03%]
Polygonatum cyrtonema多糖提取物PCP1通过抑制TLR4/NLRP3信号途径改善大鼠大脑缺血再灌注损伤
Xin Zhan,Zi-Xu Li,Zhu Yang et al.
Xin Zhan et al.
This study aims to investigate the protective effects and mechanisms of polysaccharide extract PCP1 from Polygonatum cyrtonema in ameliorating cerebral ischemia-reperfusion(I/R) injury in rats through modulation of the Toll-like receptor 4(...
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