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M Christianne Hoeberigs,Simon Tousseyn;ACE Study Group M Christianne Hoeberigs
One in seven patients with focal epilepsy has a malformation of cortical development (MCD) as underlying cause. Understanding normal cortical development combined with knowledge of where, when, and what goes wrong in different types of MCD ...
Miroo Hong,Joung-Woo Hong Miroo Hong
The enhancer threshold is defined as the minimum concentration of transcription factors (TFs) required to elicit an enhancer response in a given time and space. Here, evidence is presented that the enhancer threshold is relative to promoter...
Guofeng Feng,Guoxing Yin,Yusheng Liu et al. Guofeng Feng et al.
Naïve mouse embryonic stem cells (mESCs) are characterized by a mixed population of cells in an interconvertible pluripotent state and a totipotent 2-cell (2C)-like state. It remains to be understood how the pluripotent state is maintained...
Ying Wei,Cong Ma,Chuanfeng An et al. Ying Wei et al.
Retinal pigment epithelial (RPE) cells are specialized neural cells crucial for vision, while human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cells hold great potential as a viable cell source for treating retinal de...
Magda Correia,Carlota Tavares-Marcos,João Pessoa et al. Magda Correia et al.
Stem cells are emerging sources of antigens for cancer immunotherapy. Here, we used TNG-A mouse embryonic stem cells to trigger an anticancer response against tumors derived from E0771 mouse breast cancer cells, possibly mediated by the mou...
Akiko Soneda Hashimoto,Jianshi Yu,Christina Williams et al. Akiko Soneda Hashimoto et al.
Purpose: Signaling by the morphogen all-trans retinoic acid (RA) is critical for embryonic development, during which its tissue concentration must be tightly regulated. We investigated 8 sibships (12 individuals) segregat...
Fatemeh Davari Tanha,Azam Rasti,Hamideh Pakniat et al. Fatemeh Davari Tanha et al.
Background: Pregnancy outcomes in assisted reproductive technology (ART) are influenced by the ability of the embryos to create a pregnancy and maternal factors such as hormone levels to maintain and develop the pregnancy...
Tian Ye,Huijuan Kong,Zhiqin Bu et al. Tian Ye et al.
Background: Endometrial thickness (EMT) has been confirmed to be associated with pregnancy outcomes after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET), but studies on its relations...
Weiyu Guan,Xinran Lu,Yin Zhang et al. Weiyu Guan et al.
Background: The proper development of embryonic stomach in human is essential for the functionality of the adult stomach. However, the key genes, biological processes, and signaling pathways that influence stomach develop...
Ying Su,Haoyun Duan,Hai Zhu et al. Ying Su et al.
Primary open-angle glaucoma is a prevalent type of degenerative eye disease that results in lifelong blindness, and its critical pathogenic cause is trabecular meshwork (TM) dysfunction or decreased TM cellularity. Considering that TM devel...
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