M Christianne Hoeberigs,Simon Tousseyn;ACE Study Group
M Christianne Hoeberigs
One in seven patients with focal epilepsy has a malformation of cortical development (MCD) as underlying cause. Understanding normal cortical development combined with knowledge of where, when, and what goes wrong in different types of MCD ...
Review
Epilepsia. 2025 Jun 16. DOI:10.1111/epi.18501 2025
Miroo Hong,Joung-Woo Hong
Miroo Hong
The enhancer threshold is defined as the minimum concentration of transcription factors (TFs) required to elicit an enhancer response in a given time and space. Here, evidence is presented that the enhancer threshold is relative to promoter...
Nat10 maintains the homeostasis of pluripotent and 2-cell-like states in mouse embryonic stem cells through mRNA cytidine acetylation [0.03%]
Nat10通过mRNA胞苷乙酰化维持小鼠胚胎干细胞多能性和2细胞样状态的稳态
Guofeng Feng,Guoxing Yin,Yusheng Liu et al.
Guofeng Feng et al.
Naïve mouse embryonic stem cells (mESCs) are characterized by a mixed population of cells in an interconvertible pluripotent state and a totipotent 2-cell (2C)-like state. It remains to be understood how the pluripotent state is maintained...
Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells via injectable microfluidic-templated microgels for retinal regeneration [0.03%]
通过可注射微流控模板微凝胶移植人胚胎干细胞衍生的视网膜色素上皮细胞用于视网膜再生
Ying Wei,Cong Ma,Chuanfeng An et al.
Ying Wei et al.
Retinal pigment epithelial (RPE) cells are specialized neural cells crucial for vision, while human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cells hold great potential as a viable cell source for treating retinal de...
Claudin-6 mediates an embryonic stem cell-driven antitumor response against breast cancer [0.03%]
Claudin-6介导胚胎干细胞驱动的抗乳腺癌反应
Magda Correia,Carlota Tavares-Marcos,João Pessoa et al.
Magda Correia et al.
Stem cells are emerging sources of antigens for cancer immunotherapy. Here, we used TNG-A mouse embryonic stem cells to trigger an anticancer response against tumors derived from E0771 mouse breast cancer cells, possibly mediated by the mou...
Identification and characterization of short-chain dehydrogenase/reductase 3 (DHRS3) deficiency, a retinoic acid embryopathy of humans [0.03%]
视黄酸胚胎病人类短链脱氢酶/还原酶3(DHRS3)缺乏症的鉴定和表征
Akiko Soneda Hashimoto,Jianshi Yu,Christina Williams et al.
Akiko Soneda Hashimoto et al.
Purpose: Signaling by the morphogen all-trans retinoic acid (RA) is critical for embryonic development, during which its tissue concentration must be tightly regulated. We investigated 8 sibships (12 individuals) segregat...
Serum β-hCG, AMH, TSH, and PRL Levels in Predicting the Outcome of Early Pregnancy 14 Days after Embryo Transfer: A Prospective Cohort Study [0.03%]
β-hCG、AMH、TSH和PRL水平在胚胎移植后14天预测妊娠结局的队列研究
Fatemeh Davari Tanha,Azam Rasti,Hamideh Pakniat et al.
Fatemeh Davari Tanha et al.
Background: Pregnancy outcomes in assisted reproductive technology (ART) are influenced by the ability of the embryos to create a pregnancy and maternal factors such as hormone levels to maintain and develop the pregnancy...
A thinner endometrium is associated with a greater risk of preterm delivery after fresh cleavage embryo transfer but not after blastocyst transfer: a retrospective cohort study of 11,111 singleton live births [0.03%]
子宫内膜薄与新鲜分裂胚胎移植后早产风险增加有关,但与囊胚移植无关:一项11,111例单胎活婴的回顾性队列研究
Tian Ye,Huijuan Kong,Zhiqin Bu et al.
Tian Ye et al.
Background: Endometrial thickness (EMT) has been confirmed to be associated with pregnancy outcomes after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET), but studies on its relations...
Study on gene expression in stomach at different developmental stages of human embryos [0.03%]
人类胚胎不同发育阶段胃基因表达规律的研究
Weiyu Guan,Xinran Lu,Yin Zhang et al.
Weiyu Guan et al.
Background: The proper development of embryonic stomach in human is essential for the functionality of the adult stomach. However, the key genes, biological processes, and signaling pathways that influence stomach develop...
In Vivo Differentiation of hESC-Derived Neural Crest Cells into Trabecular Meshwork Cells [0.03%]
人胚胎干细胞源性神经嵴细胞体外分化成为小梁网细胞
Ying Su,Haoyun Duan,Hai Zhu et al.
Ying Su et al.
Primary open-angle glaucoma is a prevalent type of degenerative eye disease that results in lifelong blindness, and its critical pathogenic cause is trabecular meshwork (TM) dysfunction or decreased TM cellularity. Considering that TM devel...
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