Competing Subclones and Fitness Diversity Shape Tumor Evolution Across Cancer Types [0.03%]
竞争的亚克隆和适应度多样性塑造癌症类型间的肿瘤进化路径
Hai Chen,Jingmin Shu,Rekha Mudappathi et al.
Hai Chen et al.
Intratumor heterogeneity arises from ongoing somatic evolution complicating cancer diagnosis, prognosis, and treatment. Here we present TEATIME (es t imating e volution a ry events t hrough s i ngle-ti m epoint s e quencing), a novel comput...
The bile duct and liver cancer: ON-treatment surveillance of tumor evolution and response to systemic treatment (BILLIONSTARS) study [0.03%]
胆管和肝脏癌症：肿瘤发展及全身治疗反应的监控（BILLIONSTARS）研究
Philip Falk,Sofie Olsson Hau,Hedda Jacobsen et al.
Philip Falk et al.
Background: Malignancies of the liver and bile ducts are associated with high recurrence rates after surgery and poor prognosis when disseminated. Medical treatment has been improved in recent years, with chemotherapy, ta...
Observational Study
BMC cancer. 2025 Jun 11;25(1):1017. DOI:10.1186/s12885-025-14429-w 2025
APOBEC affects tumor evolution and age at onset of lung cancer in smokers [0.03%]
APOBEC影响吸烟者肺癌的肿瘤进化和发病年龄
Tongwu Zhang,Jian Sang,Phuc H Hoang et al.
Tongwu Zhang et al.
Most solid tumors harbor somatic mutations attributed to off-target activities of APOBEC3A (A3A) and/or APOBEC3B (A3B). However, how APOBEC3A/B enzymes affect tumor evolution in the presence of exogenous mutagenic processes is largely unkno...
APOBEC in breast cancer: a dual player in tumor evolution and therapeutic response [0.03%]
APOBEC在乳腺癌中的作用：肿瘤进化和治疗反应的双重调控因素
Haiqi Lu,Zelin Lu,Yufei Wang et al.
Haiqi Lu et al.
The APOBEC (Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like) family of cytidine deaminases has emerged as pivotal a contributor to genomic instability and adaptive immunity through DNA/RNA editing. Accumulating evidence und...
Unlocking the Genetic Secrets of Pancreatic Cancer: KRAS Allelic Imbalances in Tumor Evolution [0.03%]
胰腺癌的遗传秘密：KRAS等位基因不平衡在肿瘤进化中的作用
Vasiliki Liaki,Blanca Rosas-Perez,Carmen Guerra
Vasiliki Liaki
Pancreatic Ductal Adenocarcinoma (PDAC) belongs to the types of cancer with the highest lethality. It is also remarkably chemoresistant to the few available cytotoxic therapeutic options. PDAC is characterized by limited mutational heteroge...
Combination of tumor organoids with advanced technologies: A powerful platform for tumor evolution and treatment response (Review) [0.03%]
肿瘤类器官与先进技术结合：一种研究肿瘤进化和治疗反应的强大平台（综述）
Ying Wu,Fan Zhang,Furong Du et al.
Ying Wu et al.
Malignant tumors notably decrease life expectancy. Despite advances in cancer diagnosis and treatment, the mechanisms underlying tumorigenesis, progression and drug resistance have not been fully elucidated. An emerging method to study tumo...
Single-cell phylodynamic inference of stem cell differentiation and tumor evolution [0.03%]
单细胞系谱动力学推断干细胞分化和肿瘤进化
Kun Wang,Zhaolian Lu,Zeqi Yao et al.
Kun Wang et al.
Phylodynamic inference (PI) quantifies population dynamics and evolutionary trajectories using phylogenetic trees. Single-cell lineage tracing enables phylogenetic tree reconstruction for thousands of cells in multicellular organisms, facil...
DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer [0.03%]
广泛期小细胞肺癌的DNA损伤响应特征与一线化疗效果及肿瘤演化路径相关
Benjamin B Morris,Simon Heeke,Yuanxin Xi et al.
Benjamin B Morris et al.
Introduction: A hallmark of small cell lung cancer (SCLC) is its recalcitrance to therapy. While most SCLCs respond to frontline therapy, resistance inevitably develops. Identifying phenotypes potentiating chemoresistance...
Novel De Novo BRCA2 Variant in an Early-Onset Ovarian Cancer Reveals a Unique Tumor Evolution Pathway [0.03%]
早期卵巢癌中发现的新BRCA2变异揭示了一条独特的肿瘤进化途径
Gianmaria Miolo,Giovanni Canil,Maurizio Polano et al.
Gianmaria Miolo et al.
Ovarian cancer (OC) is a highly heterogeneous malignancy, often characterized by complex genomic alterations that drive tumor progression and therapy resistance. In this paper, we report a novel de novo BRCA2 germline variant NM_000059.3:c....
First evidence for the evolution of host manipulation by tumors during the long-term vertical transmission of tumor cells in Hydra oligactis [0.03%]
首次证据表明，在长时间的垂直传播水螅瘤细胞过程中，肿瘤对宿主的操纵发生了进化
Justine Boutry,Océane Rieu,Lena Guimard et al.
Justine Boutry et al.
While host phenotypic manipulation by parasites is a widespread phenomenon, whether tumors, which can be likened to parasite entities, can also manipulate their hosts is not known. Theory predicts that this should nevertheless be the case, ...
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