Effects of reducing sedentary behavior on liver insulin sensitivity, liver fat content, and liver enzyme levels: A six-month randomized controlled trial [0.03%]
减少久坐行为对肝脏胰岛素敏感性、肝脂肪含量和转氨酶水平影响的六月随机对照试验
Saara Laine,Tanja Sjöros,Taru Garthwaite et al.
Saara Laine et al.
Metabolic syndrome increases the risk of developing noncommunicable diseases such as metabolic dysfunction-associated steatotic liver disease. The aim was to investigate the effects of sedentary behavior (SB) reduction on liver glucose upta...
The P300-ARRDC3 axis participates in maternal subclinical hypothyroidism and is involved in abnormal hepatic insulin sensitivity in adult offspring [0.03%]
P300-ARRDC3轴参与了母体亚临床甲状腺功能减退作用并与子代成年期异常肝脏胰岛素敏感性有关
Ming Huo,Xi Yu,Xianbin Yuan et al.
Ming Huo et al.
Numerous studies have suggested potential associations between maternal subclinical hypothyroidism (SCH) and adverse metabolic outcomes in offspring, however, the underlying mechanism remains unclear. In this study, we generated a maternal ...
Protein kinase D2 modulates hepatic insulin sensitivity in male mice [0.03%]
蛋白激酶D2通过调节肝脏功能调控小鼠男性动物的胰岛素敏感性
Patricia Rada,Elena Carceller-López,Ana B Hitos et al.
Patricia Rada et al.
Objectives: Protein kinase D (PKD) family is emerging as relevant regulator of metabolic homeostasis. However, the precise role of PKD2 in modulating hepatic insulin signaling has not been fully elucidated and it is the a...
Overfeeding in the early postnatal period aggravates inflammation and hepatic insulin sensitivity in the 5α-dihydrotestosterone-induced animal model of PCOS [0.03%]
雄激素诱导的多囊卵巢综合征小鼠模型产后早期过量喂养加剧炎症和肝脏胰岛素抵抗
Nataša Veličković,Bojana Mićić,Ana Teofilović et al.
Nataša Veličković et al.
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and is closely associated with chronic low-grade inflammation and insulin resistance. To clarify the contribu...
Daily standing time, dietary fiber, and intake of unsaturated fatty acids are beneficially associated with hepatic insulin sensitivity in adults with metabolic syndrome [0.03%]
每日站立时间、膳食纤维和不饱和脂肪酸摄入量与代谢综合征成人肝脏胰岛素敏感性的有益关联
Saara Laine,Tanja Sjöros,Taru Garthwaite et al.
Saara Laine et al.
Background: Obesity is associated with impaired glucose metabolism and hepatic insulin resistance. The aim was to investigate the associations of hepatic glucose uptake (HGU) and endogenous glucose production (EGP) to sed...
Sacha Inchi (Plukenetia volubilis L.) Oil Improves Hepatic Insulin Sensitivity and Glucose Metabolism through Insulin Signaling Pathway in a Rat Model of Type 2 Diabetes [0.03%]
萨喀因奇油通过胰岛素信号途径改善2型糖尿病模型大鼠的肝脏胰岛素敏感性和糖代谢
Worarat Rojanaverawong,Navinee Wongmanee,Wanthanee Hanchang
Worarat Rojanaverawong
This study aimed to evaluate the role of sacha inchi oil (SI) in alleviating hepatic insulin resistance and improving glucose metabolism by inhibiting oxidative stress and inflammation in a rat model of type 2 diabetes. This model was estab...
The PTP1B inhibitor MSI-1436 ameliorates liver insulin sensitivity by modulating autophagy, ER stress and systemic inflammation in Equine metabolic syndrome affected horses [0.03%]
MSI-1436通过调节自噬、内质网应激和全身炎症改善代谢综合症影响的马的肝脏胰岛素敏感性
Lynda Bourebaba,Anna Serwotka-Suszczak,Ariadna Pielok et al.
Lynda Bourebaba et al.
Background: Equine metabolic syndrome (EMS) is a multifactorial pathology gathering insulin resistance, low-grade inflammation and past or chronic laminitis. Among the several molecular mechanisms underlying EMS pathogene...
SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2 [0.03%]
SLC7A14将GABA转运至溶酶体并通过对mTORC2的抑制作用损害肝脏胰岛素敏感性
Xiaoxue Jiang,Kan Liu,Haizhou Jiang et al.
Xiaoxue Jiang et al.
Lysosomal amino acid accumulation is implicated in several diseases, but its role in insulin resistance, the central mechanism to type 2 diabetes and many metabolic diseases, is unclear. In this study, we show the hepatic expression of lyso...
Selective somatostatin receptor 5 inhibition improves hepatic insulin sensitivity [0.03%]
选择性促胃泌素释放肽受体5抑制剂可改善肝脏胰岛素敏感性
Yumiko Okano Tamura,Jun Sugama,Shin-Ichi Abe et al.
Yumiko Okano Tamura et al.
Diabetes is a metabolic disorder with an increasing global prevalence. Somatostatin (SST), a peptide hormone, regulates hormone secretion via five SST receptor (SSTR) subtypes (SSTR1-5) in a tissue-specific manner. As SSTR5 is expressed in ...
Social isolation triggers oxidative status and impairs systemic and hepatic insulin sensitivity in normoglycemic rats [0.03%]
社会孤立引发氧化应激状态并损害正常血糖大鼠的全身和肝脏胰岛素敏感性
Maria Bove,Adriano Lama,Stefania Schiavone et al.
Maria Bove et al.
Drug-naïve psychotic patients show metabolic and hepatic dysfunctions. The rat social isolation model of psychosis allows to investigate mechanisms leading to these disturbances to which oxidative stress crucially contributes. Here, we inv...
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