Acteoside ameliorates hepatocyte ferroptosis and hepatic ischemia-reperfusion injury via targeting PCBP2 [0.03%]
Acteoside通过靶向PCBP2改善肝细胞铁死亡和肝脏缺血再灌注损伤
Kexin Jia,Yinhao Zhang,Fanghong Li et al.
Kexin Jia et al.
Hepatic ischemia-reperfusion injury (HIRI) has been considered as an inevitable process of liver transplantation. Hepatocyte ferroptosis is a key factor in HIRI development, yet precise mechanism and potential therapies are still unclear. H...
Pharmacological inhibition of ENaC or NCX can attenuate hepatic ischemia-reperfusion injury exacerbated by hypernatremia [0.03%]
通过药理学抑制ENaC或NCX可以缓解高钠血症加重的肝缺血再灌注损伤
Yabin Chen,Hao Li,Peihao Wen et al.
Yabin Chen et al.
Donors with a serum sodium concentration of >155 mmol/L are extended criteria donors for liver transplantation (LT). Elevated serum sodium of donors leads to an increased incidence of hepatic dysfunction in the early postoperative period of...
Effects of Adipose-Derived Mesenchymal Stem Cell-Secretome on Pyroptosis of Laparoscopic Hepatic Ischemia Reperfusion Injury in a Porcine Model [0.03%]
脂肪来源的间充质干细胞分泌组对腹腔镜肝缺血再灌注损伤猪模型中pyroptosis的影响
Yajun Ma,Lei Cao,Pujun Li et al.
Yajun Ma et al.
Extensive research has been conducted on mesenchymal stem cells (MSCs) regarding their ability to modify the immune response and reduce tissue damage. Many researchers have found that the regulatory capacity of MSCs primarily comes from the...
Engineered Macrophage Membrane-Coated Nanoparticles for Hepatic Ischemia-Reperfusion Injury Therapeutics [0.03%]
用于肝缺血再灌注损伤治疗的工程化巨噬细胞膜包被纳米药物载体
Long Yang,Weiwei Li,Zhen Huang et al.
Long Yang et al.
Hepatic ischemia-reperfusion injury (HIRI) is a common perioperative complication occurring after liver transplantation and can lead to further problems such as early allograft dysfunction (EAD). Currently, the treatment options for HIRI ar...
NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis [0.03%]
NNMT/1-MNA通过AKT/FOXO1/ANGPT2/JNK轴对抗肝脏缺血再灌注损伤
Bing Yin,Baolin Qian,Hongjun Yu et al.
Bing Yin et al.
Hepatic ischemia‒reperfusion injury (HIRI) occurs during liver surgery, contributing to postoperative complications such as liver failure, prolonged hospital stays, and increased morbidity and mortality rates. Yet, the mechanism underlying...
Sterile Inflammation and Cell Death Pathways in Liver Ischemia-Reperfusion Injury: A Review and Perspective [0.03%]
肝缺血再灌注损伤中无菌性炎症和细胞死亡途径的研究与思考——综述及展望
Weifan Huang,Wanting Meng,Jianan Zhao et al.
Weifan Huang et al.
Background: Hepatic Ischemia-Reperfusion Injury (IRI) is a critical complication in liver transplantation and resection, driven by oxidative stress and sterile inflammation mediated by damage-associated molecular patterns...
TRIM21 knockdown alleviates hemorrhage induced hepatic ischemia reperfusion injury by suppressing ferroptosis-induced NETs [0.03%]
TRIM21敲低通过抑制铁死亡诱导的NETs缓解出血引起的肝脏缺血再灌注损伤
Shikai Wang,Zhipeng Li,Yunxiang Chang et al.
Shikai Wang et al.
Hemorrhage-induced hepatic ischemia/reperfusion (I/R) injury is a severe complication of hemorrhagic shock, yet its molecular mechanisms remain unclear. The aim of this study was to investigate the potential mechanism of action of TRIM21 on...
Evaluating the diagnostic significance of the R2* value on 3.0T MRI for assessing the severity of warm hepatic ischemia-reperfusion injury [0.03%]
评估3.0T磁共振R2*值诊断价值在温暖肝缺血再灌注损伤中的应用及意义
Shichao Xu,Qian Ji,Jing Xu
Shichao Xu
Background: Magnetic resonance imaging (MRI) may be a non-invasive tool for managing warm hepatic ischemia-reperfusion injury (WHIRI). Purpose: ...
STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury [0.03%]
STING介导的线粒体DNA释放加剧了肝缺血再灌注损伤中的PANoptosis现象
Chaofeng Wu,Hongfei Miao,Zhiyong Yi et al.
Chaofeng Wu et al.
STING, a pentameric transmembrane protein, plays a vital role in regulating the innate immune response to viral and bacterial infections. Recent research has underscored its significance in acute liver injury, yet its involvement in hepatic...
Identification of PANoptosis related biomarkers to predict hepatic ischemia‒reperfusion injury after liver transplantation [0.03%]
用于预测肝移植后肝缺血再灌注损伤的PANoptosis相关生物标志物识别
Zhihong Chen,Junwei Zhang,Lei Zhang et al.
Zhihong Chen et al.
Hepatic ischemia-reperfusion injury (HIRI) is a major complication following liver transplantation. Bioinformatic analysis was performed to elucidate the PANoptosis-related molecular mechanisms underlying HIRI. Comprehensive analysis of bul...
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