Studying the Effect of Receptors Clustering on Hyaluronic Acid Binding with CD44 and the Cell Entry of Hyaluronic Acid Targeting Nanodrugs at Single Molecule/Particle Level [0.03%]
单分子/颗粒水平研究透明质酸受体聚集对细胞外基质糖胺聚糖透明质酸与受体CD44结合及透明质酸靶向纳米药物细胞摄取的影响
Xuening Li,Zhuang Zhang,Siying Li et al.
Xuening Li et al.
Receptor-ligand interactions on cell membrane play key roles in many physiological and pathological processes, especially in the nanodrug targeted delivery system. Hyaluronic acid (HA) is the main ligand for binding CD44 to modulate the tar...
The Entry of Zika Virus into the Cells and Its Implication for Antiviral Therapy [0.03%]
寨卡病毒进入细胞及其对抗病毒治疗的意义
Nahla Ahmed Hassaan,Li Xing
Nahla Ahmed Hassaan
Background: Zika virus (ZIKV) belongs to the Flavivirus genus of the Flaviviridae family. It is an enveloped RNA virus that enters host cells via receptor-mediated endocytosis. The interactions between viral proteins and particular receptor...
The Different Cellular Entry Routes for Drug Delivery Using Cell Penetrating Peptides [0.03%]
用于药物传递的细胞穿膜肽的不同细胞内吞途径
Michael Okafor,David Schmitt,Stéphane Ory et al.
Michael Okafor et al.
The cell plasma membrane acts as a semi-permeable barrier essential for cellular protection and function, posing a challenge for therapeutic molecule delivery. Conventional techniques for crossing this barrier, including biophysical and bio...
Host cell entry and neutralisation sensitivity of SARS-CoV-2 BA.3.2 [0.03%]
SARS-CoV-2 BA.3.2的宿主细胞感染性和敏感性研究
Lu Zhang,Amy Kempf,Inga Nehlmeier et al.
Lu Zhang et al.
Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain [0.03%]
识别出的中隔网状结构作为脑膜-CNS途径以用于髓样细胞进入大脑
Lindsay A Hohsfield,Sung Jin Kim,Rocio A Barahona et al.
Lindsay A Hohsfield et al.
The borders of the central nervous system (CNS) host a repertoire of immune cells and mediate critical neuroimmune interactions, including the infiltration of peripheral myeloid cells into the CNS. Despite the fundamental role of leukocyte ...
Exploring suramin's antiviral effects: targeting Lymphocytic Choriomeningitis virus cell entry and replication/transcription processes [0.03%]
探究suramin的抗病毒作用：靶向淋巴细胞脉络膜脑膜炎病毒的细胞进入及复制/转录过程
Shuzo Urata,Tomoko Tsuruta,Manabu Igarashi
Shuzo Urata
The Arenavirus family comprises of multiple pathogenic human viruses. Currently, there are no licensed vaccines or antiviral agents against arenavirus infections; therefore, there is a pressing need to develop prophylaxis and/or countermeas...
Lower Expression of SARS-CoV-2 Host Cell Entry Genes in the Intestinal Mucosa of IBD Patients With Quiescent or Mildly Active Disease [0.03%]
肠道炎性反应较低或轻度活动的IBD患者肠黏膜SARS-CoV-2宿主细胞进入基因表达降低
Laura Francesca Pisani,Gugliemo Albertini Petroni,Giorgia Crespi et al.
Laura Francesca Pisani et al.
Background: Long-term immunosuppressive therapy typically increases the risk of viral infection, yet during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, inflammatory bowel disease (IBD) patie...
Tracking of single virus: Dual fluorescent labeling of pseudorabies virus for observing entry and replication in the N2a cells [0.03%]
单病毒追踪：双荧光标记伪狂犬病病毒并观察其在N2a细胞中的入侵和复制现象
Mingzhi Li,Li Pan,Caoyuan Ma et al.
Mingzhi Li et al.
Pseudorabies virus (PRV) is a neurotropic herpesvirus. It is not easy to be track the whole replication progress of PRV, especially the nascent viral genome in the host cells. In this study, we developed a dual-fluorescence-labeled PRV (rPR...
The crystal structure of the toxin EspC from enteropathogenic Escherichia coli reveals the mechanism that governs host cell entry and cytotoxicity [0.03%]
产肠毒素大肠杆菌毒素EspC的晶体结构揭示了调控宿主细胞进入和细胞毒性的机制
Akila U Pilapitiya,Lilian Hor,Jing Pan et al.
Akila U Pilapitiya et al.
Enteropathogenic E. coli (EPEC) is a significant cause of diarrhea, leading to high infant mortality rates. A key toxin produced by EPEC is the EspC autotransporter, which is regulated alongside genes from the locus of enterocyte effacement...
Targeting Cancer With Bifunctional Peptides: Mechanism of Cell Entry and Inciting Cell Death [0.03%]
用双功能肽来针对癌症：细胞入胞机制和诱导细胞死亡原理
Maria F Setiawan,Oliver Rudan,Ingo G H Schmidt-Wolf
Maria F Setiawan
Antimicrobial peptides have gained much attention in clinical research due to their extensive possibilities of application beyond antimicrobial use. The modification of antimicrobial peptides enables the peptides to target particular cancer...
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