How Do Surface Properties of Nanoparticles Influence Their Diffusion in the Extracellular Matrix? A Model Study in Matrigel Using Polymer-Grafted Nanoparticles [0.03%]
纳米粒子的表面特性如何影响其在细胞外基质中的扩散？一项使用接枝聚合物的纳米颗粒在Matrigel中进行的模型研究
Marine Le Goas,Fabienne Testard,Olivier Taché et al.
Marine Le Goas et al.
Diffusion of nanomedicines inside the extracellular matrix (ECM) has been identified as a key factor to achieve homogeneous distribution and therefore therapeutic efficacy. Here, we sought to determine the impact of nanoparticles' (NPs) sur...
Bromelain surface modification increases the diffusion of silica nanoparticles in the tumor extracellular matrix [0.03%]
菠萝蛋白酶表面改性可增强二氧化硅纳米颗粒在肿瘤细胞外基质中的扩散能力
Alessandro Parodi,Seth G Haddix,Nima Taghipour et al.
Alessandro Parodi et al.
Tumor extracellular matrix (ECM) represents a major obstacle to the diffusion of therapeutics and drug delivery systems in cancer parenchyma. This biological barrier limits the efficacy of promising therapeutic approaches including the deli...
Shape matters: the diffusion rates of TMV rods and CPMV icosahedrons in a spheroid model of extracellular matrix are distinct [0.03%]
形状影响微管病毒和二十面体病毒在细胞外基质中的扩散速率
Karin L Lee,Logan C Hubbard,Stephen Hern et al.
Karin L Lee et al.
Nanomaterial-based carrier systems hold great promise to deliver therapies with increased efficacy and reduced side effects. While the state-of-the-art carrier system is a sphere, recent data indicate that elongated rods and filaments have ...
Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions [0.03%]
颗粒在细胞外基质中的扩散：排斥型静电相互作用的影响
Triantafyllos Stylianopoulos,Ming-Zher Poh,Numpon Insin et al.
Triantafyllos Stylianopoulos et al.
Diffusive transport of macromolecules and nanoparticles in charged fibrous media is of interest in many biological applications, including drug delivery and separation processes. Experimental findings have shown that diffusion can be signif...
Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix [0.03%]
同二聚体控制成纤维细胞生长因子9亚家族的受体结合和硫酸乙酰肝素依赖性在细胞外基质中的扩散
Juliya Kalinina,Sara A Byron,Helen P Makarenkova et al.
Juliya Kalinina et al.
Uncontrolled fibroblast growth factor (FGF) signaling can lead to human diseases, necessitating multiple layers of self-regulatory control mechanisms to keep its activity in check. Herein, we demonstrate that FGF9 and FGF20 ligands undergo ...
Diffusion and reaction in the cell glycocalyx and the extracellular matrix [0.03%]
细胞糖萼和细胞外基质中的扩散与反应
Howard A Levine,Maria P McGee,Susana Serna
Howard A Levine
Many biologically important macromolecular reactions are assembled and catalyzed at the cell lipid-surface and thus, the extracellular matrix and the glycocalyx layer mediate transfer and exchange of reactants and products between the flowi...