Dual-Function Fluorescent Probes for Neuronal Trans-Differentiation: A Promising Therapeutic Strategy in Neuroregenerative Research [0.03%]
用于神经重编程的双重功能荧光探针：神经再生研究中的有希望的治疗策略
Pratikshya Paudel,Prabir Kumar Gharai
Pratikshya Paudel
Neurodegenerative diseases cause progressive neuronal loss, with current treatments offering only limited symptomatic relief. To overcome this, various strategies are being explored. One promising approach involves converting human mesenchy...
Drp1-Mediated Mitochondrial Fission Is Essential for Chemical-Induced Neuronal Transdifferentiation from Human Primary Fibroblasts [0.03%]
基于人原代成纤维细胞的化学诱导神经重编程过程中线粒体分裂的介导因素及作用机制研究
Jijuan Yang,Chun Li,Chunhua Wang et al.
Jijuan Yang et al.
Neuronal replacement therapy recently holds promise for neurodegenerative disease treatment. Somatic cell-derived neurons are the main cell source for this therapy; however, the induction mechanisms remain to be fully elucidated. Emerging e...
Changing genes, cells and networks to reprogram the brain after stroke [0.03%]
脑卒中后的基因、细胞和网络的改变以重新编程大脑
Wenlu Li,Paul George,Matine M Azadian et al.
Wenlu Li et al.
Important advances have been made in reperfusion therapies for acute ischemic stroke. However, a majority of patients are either ineligible for or do not respond to treatments and continue to have considerable functional deficits. Stroke re...
Direct Neural Reprogramming in situ: Existing Approaches and Their Optimization [0.03%]
直接神经重编程的现有方法及优化措施
Nikita V Dokukin,Daria A Chudakova,Matvey O Shkap et al.
Nikita V Dokukin et al.
Direct in situ neuronal reprogramming (transdifferentiation) of glial cells (astrocytes and microglia) has attracted a significant interest as a potential approach for the treatment of a wide range of neurodegenerative diseases and damages ...
Identification of the core regulatory program driving NEUROD1-induced neuronal reprogramming [0.03%]
鉴定NEUROD1诱导的神经重编程的核心调节程序
Wen Li,Dan Su,Xining Li et al.
Wen Li et al.
NEUROD1 (ND1)-induced astrocyte-to-neuron (AtN) conversion shows promise for treating neurological disorders. To gain insight into the molecular mechanisms of neuronal reprogramming, we established an in vitro system using primary cortical ...
A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia [0.03%]
一种多路复用的单细胞测序筛选技术，鉴定出了能够促进小鼠Müller胶质细胞重编程为神经元的化合物
Amy Tresenrider,Marcus Hooper,Levi Todd et al.
Amy Tresenrider et al.
Retinal degeneration in mammals causes permanent loss of vision, due to an inability to regenerate naturally. Some non-mammalian vertebrates show robust regeneration, via Muller glia (MG). We have recently made significant progress in stimu...
Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming [0.03%]
通过直接神经元重编模拟晚发性阿尔茨海默病的神经病理学
Zhao Sun,Ji-Sun Kwon,Yudong Ren et al.
Zhao Sun et al.
Late-onset Alzheimer's disease (LOAD) is the most common form of Alzheimer's disease (AD). However, modeling sporadic LOAD that endogenously captures hallmark neuronal pathologies such as amyloid-β (Aβ) deposition, tau tangles, and neuron...
Controlling the Expression Level of the Neuronal Reprogramming Factors for a Successful Reprogramming Outcome [0.03%]
通过调控神经重编程因子表达水平实现高效诱导神经元转型
Natalie Mseis-Jackson,Mehek Sharma,Hedong Li
Natalie Mseis-Jackson
Neuronal reprogramming is a promising approach for making major advancement in regenerative medicine. Distinct from the approach of induced pluripotent stem cells, neuronal reprogramming converts non-neuronal cells to neurons without going ...
Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1 [0.03%]
直接重编程诱导的小胶质细胞和星形胶质细胞转分化为功能性神经元伴随着表观遗传组的重塑，并且需要Yy1因子的参与
Allwyn Pereira,Jeisimhan Diwakar,Giacomo Masserdotti et al.
Allwyn Pereira et al.
Direct neuronal reprogramming is a promising approach to regenerate neurons from local glial cells. However, mechanisms of epigenome remodeling and co-factors facilitating this process are unclear. In this study, we combined single-cell mul...
Advances in neuronal reprogramming for neurodegenerative diseases: Strategies, controversies, and opportunities [0.03%]
神经元重编程在神经退行性疾病研究中的进展、争议及前景
Si-Tong Li,Yue Wan,Li Chen et al.
Si-Tong Li et al.
Neuronal death is often observed in central nervous system injuries and neurodegenerative diseases. The mammalian central nervous system manifests limited neuronal regeneration capabilities, and traditional cell therapies are limited in the...
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