A rare case report of delayed thyroxine hypersensitivity: Challenges and management strategies [0.03%]
延迟性甲状腺素过敏的罕见病例报告：挑战与管理策略
A Kari Halimah Hana,Ahmad Saharuddin
A Kari Halimah Hana
Herein, we present the case of a 45-year-old woman with a history of Graves' disease who underwent radioactive iodine therapy and was prescribed different oral preparations of thyroxine. Despite initial tolerance to the medication, she deve...
Yusen Qiu,Dandan Tan,Min Zhu et al.
Yusen Qiu et al.
Evaluating the performance and potential bias of predictive models for detection of transthyretin cardiac amyloidosis [0.03%]
评估转甲状腺素蛋白心脏淀粉样变性检测预测模型性能和潜在偏差
Jonathan Hourmozdi,Nicholas Easton,Simon Benigeri et al.
Jonathan Hourmozdi et al.
Background: Delays in the diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) contribute to the significant morbidity of the condition, especially in the era of disease-modifying therapies. Screening for ATTR-CM w...
Monoclonal Antibodies to Thyrotropin Receptor With Thyroid-Stimulating Activity Activate the NF-κB Pathway to Induce Chemokine Expression [0.03%]
促甲状腺素受体单克隆抗体通过激活NF-κB通路诱导化学因子表达
Yang Yang,Chen Hui
Yang Yang
The A subunit of thyrotropin receptor (TSHR) is thought to be the crucial gene mediating stimulatory autoantibodies in Graves' diease (GD), but it remains unclear what the molecular basis of this pathological antibody response is. Stimulato...
Levothyroxine in Pregnancy: Protective Neurodevelopmental Role Beyond Cognitive Outcomes? [0.03%]
左旋甲状腺素与妊娠：超出认知结果之外的神经发育保护作用？
Freddy J K Toloza,Sangeetha Gummalla,Spyridoula Maraka
Freddy J K Toloza
Real-World Utilization Patterns, Safety, and Efficacy of Tafamidis in Patients With Hereditary Transthyretin Amyloidosis in Japan [0.03%]
日本遗传性转甲状腺素蛋白淀粉样变患者中tafamidis的使用模式、安全性及疗效：真实世界研究
Hiroaki Konishi,Hajime Abe,Noriko Matsumoto et al.
Hiroaki Konishi et al.
Purpose: Patients with hereditary transthyretin (ATTRv) amyloidosis experience progressive degeneration of the somatic and peripheral nervous system that can impair ambulation, autonomy, and quality of life (QOL). Tafamid...
Comparison of two genetic strategies for diagnostic work-up of hypertrophic cardiomyopathy: impact on the diagnosis of Fabry disease or transthyretin amyloidosis [0.03%]
两种基因策略在肥厚型心肌病诊断中的比较：对法布雷病或转甲状腺素蛋白淀粉样变性诊断的影响
Aurélien Palmyre,Fairouz Koraichi,Flavie Ader et al.
Aurélien Palmyre et al.
Background: Diagnostic work-up of patients with hypertrophic cardiomyopathy is crucial for appropriate management. However, the optimal genetic strategy remains debatable. We compared two strategies: targeted testing base...
Levothyroxine therapy in thyroidectomized patients: ongoing challenges and controversies [0.03%]
甲状腺切除患者的左旋甲状腺素治疗：持续的挑战和争议
Leonardo Rossi,Marinunzia Paternoster,Mattia Cammarata et al.
Leonardo Rossi et al.
This mini-review provides an update on the challenges and controversies surrounding levothyroxine therapy in thyroidectomized patients, following an extensive review on dosing strategies and available formulations. Despite efforts to establ...
Application of a transthyretin amyloid cardiomyopathy score to heart failure with mildly reduced or preserved ejection fraction [0.03%]
轻度降低或保留射血分数的心力衰竭中转甲状腺素淀粉样心肌病评分的应用
Riccardo M Inciardi,Muthiah Vaduganathan,Brian Claggett et al.
Riccardo M Inciardi et al.
Aims: The safety and efficacy of heart failure (HF)-directed medical therapy among patients who might be considered for further diagnostic evaluation to rule out transthyretin amyloid cardiomyopathy (ATTR-CM) is largely u...
Exploring the role of glial fibrillary acid protein and neurofilament light chains in patients with hereditary transthyretin amyloidosis with polyneuropathy [0.03%]
载脂蛋白和神经丝轻链在遗传性转甲状腺素蛋白淀粉样变多发性神经病患者中的作用探讨
Caterina Maria Gambino,Luisa Agnello,Vincenzo Di Stefano et al.
Caterina Maria Gambino et al.
Objectives: Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a rare, progressive neurodegenerative disorder caused by mutations in the transthyretin (TTR) gene. The disease leads to systemic amyloid ...
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