A backhanded complement: Prostacyclin turns inflammation off from the inside out [0.03%]
矛盾的赞誉：前列环素从里到外减弱炎症反应
Samuel E J Preston,Russell G Jones
Samuel E J Preston
To limit hyperactive T helper (Th)1-driven pathology, it is crucial that this T cell population contracts upon pathogen clearance. In this issue of Immunity, Rahman et al. define a complement-C5-mediated lipid-class-switch mechanism that re...
Multi-omic spatially resolved analysis of the neuroinflammatory response to intracortical microelectrode arrays [0.03%]
颅内微电极阵列诱导的神经炎症的多组学空间分辨分析
Lindsey N Druschel,Sydney S Song,Niveda M Kasthuri et al.
Lindsey N Druschel et al.
Intracortical microelectrode arrays (MEAs) are devices implanted into the brain's cortex with the ability to record or stimulate neuronal activity. Unfortunately, MEAs tend to fail over chronic time points, limiting their clinical utility. ...
Protective role of pinocembrin in a rat model of intestinal ischemia-reperfusion injury [0.03%]
染料木黄酮通过下调TLR4/NF-κB信号通路减轻肠缺血再灌注损伤诱导的肠道与肺脏炎症反应
Osman Bardakçı,Hakim Çelik,İlyas Özardalı et al.
Osman Bardakçı et al.
Purpose: To determine whether pinocembrin (PC) confers protective effects against experimentally induced intestinal ischemia-reperfusion (I/R) injury in rats. ...
AMPAR inhibition lowers S1P in human blood and improves murine autoimmune neuroinflammation by blocking T cell egress from lymph nodes [0.03%]
AMPAR抑制可降低人体血液中的S1P水平并通过阻断淋巴结中T细胞的输出来改善小鼠自身免疫性神经炎症反应
Beatrice Wasser,Manuela Ecker,Nicholas Hanuscheck et al.
Beatrice Wasser et al.
Glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated signaling in neurons acts through regulation of ion channels. In T cells, we uncovered a noncanonical AMPAR-mediated metabotropic Gi protein-coupl...
Dynamics of Innate Immunity in SARS-CoV-2 Infections: Exploring the Impact of Natural Killer Cells, Inflammatory Responses, Viral Evasion Strategies, and Severity [0.03%]
SARS-CoV-2感染的固有免疫动力学：探索自然杀伤细胞、炎症反应、病毒逃避策略和严重性的影响
Juan C Batista,Rodrigo DeAntonio,Sandra López-Vergès
Juan C Batista
The COVID-19 pandemic, caused by SARS-CoV-2, has had a profound impact on global health, with nearly 800 million cases reported in the Americas alone. The clinical presentation of the disease is highly variable, with approximately half of a...
Paeoniflorin Alleviates Immune Inflammation in Submandibular Gland Epithelial Cells in Sjögren's Syndrome Through Multiple Signaling Pathways [0.03%]
芍药苷通过多条信号通路缓解舍格伦综合征下颌腺上皮细胞免疫炎症反应
Zou Xudan,Chen Yueyue,Wu Suling
Zou Xudan
Endogenous SLPI contributes to the regulation of inflammatory responses in peritoneal macrophages by modulating MMP-9 production [0.03%]
内源性SLPI通过调节MMP-9的产生来参与腹腔巨噬细胞炎症反应的调控
Mariia Tyshchenko,Natalia Pocałuń,Patrycja Kwiecińska et al.
Mariia Tyshchenko et al.
Secretory leukocyte protease inhibitor (SLPI) is described as a potent regulator of inflammation and tissue homeostasis with pleiotropic functions. It has been shown to inhibit pro-inflammatory responses in myeloid cells. However, its expre...
Plasmon-activated water enhances gut-barrier function and alleviates inflammation in a mouse model of ulcerative colitis [0.03%]
等离子活化水增强溃疡性结肠炎小鼠肠道屏障功能并减轻炎症反应
Chun-Chao Chang,Chih-Ju Chang,Chih-Yi Liu et al.
Chun-Chao Chang et al.
Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease characterized by disruption of the intestinal epithelial barrier and alterations in mucosal gene expression associated with intestinal integrity. Given the risks ass...
Influenza-induced microRNA-155 expression is altered in extracellular vesicles derived from the COPD epithelium [0.03%]
流感感染通过囊泡传递miR-155加重慢阻肺小鼠模型的炎症反应
Laura V Reid,C Mirella Spalluto,Tom M A Wilkinson et al.
Laura V Reid et al.
Background: Influenza virus particularly affects those with chronic lung conditions such as Chronic Obstructive Pulmonary Disease (COPD). Airway epithelial cells are the first line of defense and primary target of influen...
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