Efficient Enrichment of Docosahexaenoic Acid (DHA) in Mother's Milk and in the Brain and Retina of the Offspring by Lysophosphatidylcholine (LPC)-DHA in the Maternal Diet [0.03%]
通过母体摄入溶血磷脂胆碱-DHA高效增加母乳以及促进后代大脑和视网膜DHA含量
Poorna C R Yalagala,Dhavamani Sugasini,Sutape Chantapim et al.
Poorna C R Yalagala et al.
Background: Docosahexaenoic acid (DHA) is the most important fatty acid (FA) for the development and function of brain and retina. Mother's milk is the predominant source of DHA for the baby's postnatal life, and the omega 3 FA content of a...
Lysophosphatidic acid and sphingosine-1-phosphate are apical polarity cues in multiple organoid systems [0.03%]
lysophosphatidic酸和鞘氨醇-1-磷酸是多个类器官系统中的顶极化提示因子
Andrew M Tidball,Jinghui Luo,J Clayton Walker et al.
Andrew M Tidball et al.
Apicobasal polarization is crucial for tissue organization during in vivo development and in human organoid models. Extracellular matrix (ECM) signaling typically provides a basal cue, and intestinal and lung organoids reverse polarity from...
Neuroinflammation in an optimized model of lysophosphatidic acid (LPA)-induced post-hemorrhagic hydrocephalus [0.03%]
神经炎症在优化的血性脑积水诱导模型中的作用：溶血磷脂酸的作用
Paloma Sánchez-Pavón,Carter R Palmer,Christine S Liu et al.
Paloma Sánchez-Pavón et al.
Post-hemorrhagic hydrocephalus (PHH) is a neurological disease that primarily affects premature infants and involves infiltration of blood into the brain's ventricles followed by excessive accumulation of cerebrospinal fluid (CSF), leading ...
Lipid profiling of Parkinson's disease brain highlights disruption in Lysophosphatidylcholines, and triacylglycerol metabolism [0.03%]
帕金森病大脑脂质组分析显示溶血磷脂酰胆碱及三酰甘油代谢紊乱
Ali Yilmaz,Nadia Ashrafi,Romana Ashrafi et al.
Ali Yilmaz et al.
Parkinson's disease (PD) is the second most common neurodegenerative disorder following Alzheimer's disease, with a 1.5 times higher prevalence in males. Several lipid-related genetic risk factors for PD have been identified, and the brain ...
Multi-omics interpretation of how lysophospholipids regulate hepatic lipid metabolism and immunity in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ Epinephelus Lanceolatu) fed high-lipid diets [0.03%]
lysophospholipids调节石斑鱼肝脂代谢和免疫的多组学解析
Hongjin Deng,Jiacheng Zhang,Weixing Liang et al.
Hongjin Deng et al.
This experiment explored the effects of lysophospholipids on hybrid grouper (initial average weight: 22.65 ± 0.03 g) hepatic lipid metabolism and immunity at the transcriptome and metabolome levels. A total of 375 hybrid groupers were divi...
Lysophosphatidylcholine as a biomarker for severe aortic stenosis in diabetic patients: Preliminary report [0.03%]
糖尿病患者的重度主动脉瓣狭窄溶血磷脂酰胆碱生物标志物的初步研究报告
Anna Olasińska-Wiśniewska,Tomasz Urbanowicz,Paweł Gutaj et al.
Anna Olasińska-Wiśniewska et al.
Can a novel lysophosphatidic acid receptor 1 antagonist ACT in time to halt pulmonary fibrosis and improve breathing? [0.03%]
新型溶血磷脂酸受体1拮抗剂能否及时用于阻止肺纤维化并改善呼吸？
Bradley T Andresen
Bradley T Andresen
Role of Lysophosphatidic Acid in Neurological Diseases: From Pathophysiology to Therapeutic Implications [0.03%]
溶血磷脂酸在神经疾病中的作用：从病理生理到治疗意义
Simona Dedoni,Valeria Avdoshina,Maria C Olianas et al.
Simona Dedoni et al.
Lysophosphatidic acid (LPA), a bioactive lipid molecule, has been identified as a critical regulator of several cellular processes in the central nervous system, with significant impacts on neuronal function, synaptic plasticity, and neuroi...
Autocrine/paracrine lysophosphatidylserine signaling suppresses B cell aggregation and tertiary lymphoid structure formation [0.03%]
自分泌旁分泌溶血磷脂酰丝氨酸信号抑制B细胞聚集和三级淋巴结构形成
Akiharu Uwamizu,Yuji Shinjo,Jumpei Omi et al.
Akiharu Uwamizu et al.
Accumulating evidence suggests that Gα13 signaling by G protein-coupled receptors negatively regulate B cell function. We report here that lysophosphatidylserine (LysoPS), an emerging immunoregulatory lysophospholipid, is produced upon B c...
Lysophospholipid stereoisomers exert distinct GPR55-mediated functions via different Gα subunits [0.03%]
磷脂衍生物立体异构体通过不同的Gα亚基发挥不同的GPR55介导的生理功能
Adam T Guy,Yuta Kohro,Koki Kano et al.
Adam T Guy et al.
Vertebrate glycerophospholipids typically exhibit a glycerol-3-phosphate (G3P)-configured backbone corresponding to the R-configured stereoisomer at the sn-2 chiral center. We previously found that the lysoglycerophospholipid lyso-phosphati...
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