Base Excision Repair in Mitotic Cells and the Role of Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Post-Mitotic Transcriptional Reactivation of Genes [0.03%]
有丝分裂细胞中的碱基切除修复及无嘌呤/无嘧啶内切酶1(APE1)在静止期基因转录重新激活中的作用
Suravi Pramanik,Yingling Chen,Kishor K Bhakat
Suravi Pramanik
Endogenous DNA damage occurs throughout the cell cycle, with cells responding differently at various stages. The base excision repair (BER) pathway predominantly repairs damaged bases in the genome. While extensively studied in interphase c...
Molecular Basis for the Calcium-Dependent Activation of the Ribonuclease EndoU [0.03%]
内切酶EndoU钙离子激活的分子机制研究
Florian Malard,Kristen Dias,Margaux Baudy et al.
Florian Malard et al.
Ribonucleases (RNases) are ubiquitous enzymes that process or degrade RNA, essential for cellular functions and immune responses. The EndoU-like superfamily includes endoribonucleases conserved across bacteria, eukaryotes, and certain virus...
The biological function of cytoplasm-translocated ENDOG (endonuclease G) [0.03%]
胞质内转移的ENDOG(脱氧核糖核酸内切酶G)的功能研究
Wenjun Wang,Jianshuang Li,Qinghua Zhou
Wenjun Wang
ENDOG, a mitochondrial intermembrane space located endonuclease, participates in DNA fragmentation and apoptosis by translocating to the nucleus. ENDOG can also relocate to the mitochondrial matrix, where it regulates mitochondrial genome c...
Xuanshuo Wei,Jin Tang,Chuwen Lin et al.
Xuanshuo Wei et al.
The typical function of Drosha is participating in cleaving pri-miRNA, the initial step of miRNA biogenesis, in the nucleus. Since Drosha has a double-stranded RNA-binding domain and two RNase III domains, when it binds and/or cleaves other...
Origin and Evolution of Plant Long Terminal Repeat Retrotransposons with Additional Ribonuclease H [0.03%]
具有额外核糖核酸内切酶H的植物长末端重复逆转录转座子的起源和进化
Mikhail Biryukov,Kirill Ustyantsev
Mikhail Biryukov
Retroviruses originated from long terminal repeat retrotransposons (LTR-RTs) through several structural adaptations. One such modification was the arrangement of an additional ribonuclease H (aRH) domain next to native RH, followed by degra...
AND-Gated Nanosensor for Imaging of Glutathione and Apyrimidinic Endonuclease 1 in Cells, Animals, and Organoids [0.03%]
适用于细胞、动物和类器官中谷胱甘肽和无嘧啶末端脱氧核糖核酸内切酶1的AND门纳米传感器成像技术
Zening Huang,Kaixiang Xu,Lijuan Zhao et al.
Zening Huang et al.
The development of a strategy for imaging of glutathione (GSH) and apurinic/apyrimidinic endonuclease 1 (APE1) in an organism remains challenging despite their significance in elaborating the correlated pathophysiological processes. Therefo...
Role of PumB antitoxin as a transcriptional regulator of the PumAB type-II toxin-antitoxin system and its endoribonuclease activity on the PumA (toxin) transcript [0.03%]
PumB毒素抗毒素作为PumAB类型II毒素-抗毒素系统转录调节因子的作用及其对PumA（毒素）转录的内切核糖核酸酶活性
K C Hernández-Ramírez,M I Valle-Maldonado,J A Patiño-Medina et al.
K C Hernández-Ramírez et al.
The PumAB type-II toxin-antitoxin (TA) system is encoded by pumAB genes that are organized into an operon. This system is encoded by the pUM505 plasmid, isolated from a Pseudomonas aeruginosa clinical strain. The pumA gene encodes a putativ...
IRE-1 endoribonuclease activity declines early in C. elegans adulthood and is not rescued by reduced reproduction [0.03%]
在C. elegans 成熟早期IRE-1 内切核酸酶活性下降且不会因繁殖减少而得到恢复
Evandro A De-Souza,Nadia Cummins,Rebecca C Taylor
Evandro A De-Souza
The proteome of a cell helps to define its functional specialization. Most proteins must be translated and properly folded to ensure their biological function, but with aging, animals lose their ability to maintain a correctly folded proteo...
Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors [0.03%]
连续荧光基末端脱氧核糖核酸内切酶耦联甲基化测定筛选脱氧核糖核酸甲基转移酶抑制剂
Rebecca Switzer,Katie A Ward,Jessica Medrano
Rebecca Switzer
DNA methylation, a form of epigenetic gene regulation, is important for normal cellular function. In cells, proteins called DNA methyltransferases (DNMTs) establish and maintain the DNA methylation pattern. Changes to the normal DNA methyla...
A novel compound active against SARS-CoV-2 targeting uridylate-specific endoribonuclease (NendoU/NSP15): in silico and in vitro investigations [0.03%]
一种针对SARS-CoV-2新型化合物的体内外研究：以尿苷酸特异性核糖核酸内切酶（NendoU/NSP15）为靶点
Sumit Kumar,Yash Gupta,Samantha E Zak et al.
Sumit Kumar et al.
NendoU (NSP15) is an Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. Our in-house library was subjected to high throughput virtual screening (HTVS) to identify compounds with potenti...
耗时 0.25316 秒，为您在
48229835
条记录里面共找到 143 篇文章 [XML]