The Drosophila amyloid precursor protein homologue mediates neuronal survival and neuroglial interactions [0.03%]
果蝇淀粉样前体蛋白同源物介导神经元存活和神经胶质相互作用
Irini A Kessissoglou,Dominique Langui,Amr Hasan et al.
Irini A Kessissoglou et al.
The amyloid precursor protein (APP) is a structurally and functionally conserved transmembrane protein whose physiological role in adult brain function and health is still unclear. Because mutations in APP cause familial Alzheimer's disease...
A Role for Drosophila Amyloid Precursor Protein in Retrograde Trafficking of L1-Type Cell Adhesion Molecule Neuroglian [0.03%]
果蝇淀粉样前体蛋白在L1型神经细胞黏附分子Neuroglian反式运输中的作用
Tyrone Penserga,Sirisha Rani Kudumala,Richelle Poulos et al.
Tyrone Penserga et al.
The role of the Amyloid Precursor Protein (APP) in the pathology of Alzheimer's disease (AD) has been well studied. However, the normal function of APP in the nervous system is poorly understood. Here, we characterized the role of the Droso...
Drosophila Full-Length Amyloid Precursor Protein Is Required for Visual Working Memory and Prevents Age-Related Memory Impairment [0.03%]
果蝇全长淀粉样前体蛋白对视觉得工作记忆是必需的，并且能够防止年龄相关的记忆力减退
Franziska Rieche,Katia Carmine-Simmen,Burkhard Poeck et al.
Franziska Rieche et al.
The β-amyloid precursor protein (APP) plays a central role in the etiology of Alzheimer's disease (AD). However, its normal physiological functions are still unclear. APP is cleaved by various secretases whereby sequential processing by th...
Thomas Preat,Valérie Goguel
Thomas Preat
The amyloid precursor protein (APP) is a membrane protein engaged in complex proteolytic pathways. APP and its derivatives have been shown to play a central role in Alzheimer's disease (AD), a progressive neurodegenerative disease character...
The full-length form of the Drosophila amyloid precursor protein is involved in memory formation [0.03%]
果蝇淀粉样前体蛋白的全长形式参与记忆的形成
Isabelle Bourdet,Thomas Preat,Valérie Goguel
Isabelle Bourdet
The APP plays a central role in AD, a pathology that first manifests as a memory decline. Understanding the role of APP in normal cognition is fundamental in understanding the progression of AD, and mammalian studies have pointed to a role ...
The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling [0.03%]
果蝇淀粉样前体蛋白同系物是Wnt平面细胞极性信号转导的保守调节因子
Alessia Soldano,Zeynep Okray,Pavlina Janovska et al.
Alessia Soldano et al.
Wnt Planar Cell Polarity (PCP) signaling is a universal regulator of polarity in epithelial cells, but it regulates axon outgrowth in neurons, suggesting the existence of axonal modulators of Wnt-PCP activity. The Amyloid precursor proteins...
β-secretase cleavage of the fly amyloid precursor protein is required for glial survival [0.03%]
果蝇淀粉样前体蛋白的β-分泌酶切割作用可确保维持胶质细胞存活
Bonnie J Bolkan,Tilman Triphan,Doris Kretzschmar
Bonnie J Bolkan
β-secretase (or BACE1) is the key enzyme in the production of β-amyloid (Aβ), which accumulates in the senile plaques characteristic for Alzheimer's disease. Consequently, the lack of BACE1 prevents β-processing of the amyloid precursor...
Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport [0.03%]
果蝇淀粉样前体蛋白(APPL)的神经元过表达会干扰轴突运输
L Torroja,H Chu,I Kotovsky et al.
L Torroja et al.
The two pathological hallmarks of Alzheimer's disease, amyloid plaques and neurofibrillary tangles, involve two apparently unrelated proteins, the amyloid precursor protein (APP) and Tau. Although it is known that aberrant processing of APP...