Clinical Trial Protocol: Impact of Testosterone Replacement Therapy on Functional and Oncological Outcomes Following Radical Prostatectomy (ENFORCE Study) [0.03%]
术后睾酮替代治疗对根治性前列腺切除术功能和肿瘤结局影响的临床试验方案（ENFORCE研究）
Diederik Baas,Joost van Drumpt,Lambertus Kiemeney et al.
Diederik Baas et al.
Background and objective: Testosterone deficiency (TD) affects 18-38% of men undergoing radical prostatectomy (RP) for localised prostate cancer and may impair postoperative sexual rehabilitation. Testosterone replacement...
Acute skeletal muscle wasting in patients with acute kidney injury requiring continuous kidney replacement therapy: A prospective multicenter study [0.03%]
连续性肾脏替代治疗急性肾损伤患者的急性骨骼肌消耗：一项前瞻性多中心研究
Kirby P Mayer,J Pedro Teixeira,Felipe González-Seguel et al.
Kirby P Mayer et al.
Purpose: Acute kidney injury (AKI) requiring continuous kidney replacement therapy (CKRT) has been hypothesized to increase the risk of developing intensive care unit-associated weakness (ICU-AW), but prospective data are...
Efficacy and Safety of Hormone Replacement Combined With Escitalopram in the Treatment of Chronic Insomnia in Perimenopausal Women: A Randomized Controlled Trial [0.03%]
激素替代治疗联合艾司西酞普兰治疗围绝经期慢性失眠的疗效及安全性研究：随机对照试验
Hui Chen,Shufang Wu,Hongbin Chen et al.
Hui Chen et al.
Aims: To explore the efficacy of Femoston plus escitalopram for perimenopausal women with chronic insomnia and the relevant biomarkers. Methods: ...
Randomized Controlled Trial
CNS neuroscience & therapeutics. 2025 Jun;31(6):e70470. DOI:10.1111/cns.70470 2025
Evaluation of Epigenetic Age Acceleration in Growth Hormone (GH)-Deficient Children After 6 Months of Recombinant Human GH Replacement Therapy: Anti-Ageing GH vs. Pro-Ageing Insulin-like Growth Factor 1 (IGF-1)? [0.03%]
生长激素缺乏儿童6个月重组人生长激素替代治疗后表观遗传学年龄加速评估：抗衰老生长激素VS促衰老胰岛素样生长因子1？
Antonello E Rigamonti,Valentina Bollati,Chiara Favero et al.
Antonello E Rigamonti et al.
Background: One of the most debated topics in experimental and clinical endocrinology is the impact of hypo- and hyper-somatotropism on the extension/shortening of the lifespan, the results of experimental, clinical, and epidemiological stu...
Uterine Artery Embolization as an Alternative Therapeutic Option in Adenomyosis: An Observational Retrospective Single-Center Study [0.03%]
子宫动脉栓塞作为腺肌症的替代治疗方案：一项观察性回顾性单中心研究
Melinda-Ildiko Mitranovici,Dan Costachescu,Dan Dumitrascu-Biris et al.
Melinda-Ildiko Mitranovici et al.
Adenomyosis is a benign gynecologic disease that mainly affects women aged 30-50 years old. Background: This pathology is characterized by glands and stroma of the endometrium that enter the myometrium and is confirmed through histopatholog...
The Urea-Creatinine Ratio as Marker of Catabolism Is Affected by Continuous Renal Replacement Therapy [0.03%]
连续性肾脏替代治疗影响尿素肌酐比这一分解代谢标志物
Andreas Markl-Le Levé,Petra Hillinger,Simon Woyke et al.
Andreas Markl-Le Levé et al.
Background: An elevated urea-creatinine ratio (UCR) is used as a surrogate for catabolism and elevated protein metabolism in critically ill patients. This study investigated the effect of continuous renal replacement therapy (CRRT) on UCR. ...
Successful Pregnancy Outcome in Patient with Pompe Disease Despite Discontinuation of Enzyme Replacement Therapy [0.03%]
Pompe病患者停用酶替代治疗后成功妊娠及分娩
Dunja Leskovar Lemešić,Dražen Perica,Gordan Zlopaša et al.
Dunja Leskovar Lemešić et al.
Background: Pompe disease (PD), is an autosomal recessive metabolic disorder caused by mutations in the acid alpha-glucosidase (GAA) gene, resulting in a deficiency of the same enzyme and glycogen buildup in tissues. Late...
Association of Platelet Trajectory Patterns with In-Hospital Mortality in Critically Ill Adults with Acute Kidney Injury Receiving Continuous Renal Replacement Therapy [0.03%]
连续肾脏替代治疗急性肾损伤危重成人患者血小板轨迹模式与住院死亡率的关系：一项观察性队列研究
Tomonori Takeuchi,Udeme Ekrikpo,Joshua Lambert et al.
Tomonori Takeuchi et al.
Background: Thrombocytopenia commonly occurs in critically ill patients with acute kidney injury (AKI) receiving continuous renal replacement therapy (CRRT) and is associated with poor outcomes. While previous studies have examined static p...
Clinical outcomes of pancrelipase administration after pancreaticoduodenectomy [0.03%]
胰腺十二指肠切除术后胰酶补充的临床效果分析
Teruyuki Usuba,Ryota Iwase,Yuichi Nakaseko et al.
Teruyuki Usuba et al.
Purposes: This study investigated the risk factors for nonalcoholic fatty liver disease (NAFLD) after pancreaticoduodenectomy (PD) and the need for prophylactic pancrelipase administration in all patients. ...
Hemodiafiltration Should Be the Primary In-Center Kidney Replacement Modality in End Stage Kidney Disease: CON [0.03%]
血液透析滤过不应作为终末期肾脏病患者主要的住院替代治疗手段：反对观点
Khounish Sharma,Eugene Lin
Khounish Sharma
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