Exploring covalent inhibitors of SARS-CoV-2 main protease: from peptidomimetics to novel scaffolds [0.03%]
用于探索SARS-CoV-2主要蛋白酶共价抑制剂：从肽模拟物到新骨架分子
Noor Atatreh,Radwa E Mahgoub,Mohammad A Ghattas
Noor Atatreh
Peptidomimetic inhibitors mimic natural peptide substrates, employing electrophilic warheads to covalently interact with the catalytic Cys145 of Mpro. Examples include aldehydes, α-ketoamides, and aza-peptides, with discussions on their me...
Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity [0.03%]
设计、合成并揭示与冠状病毒及其变异毒株的主要蛋白酶具有前所未有的相互作用的二肽类共价抑制剂及其抗病毒活性研究
Philipp Flury,Nadine Krüger,Katharina Sylvester et al.
Philipp Flury et al.
The main protease (Mpro) of SARS-CoV-2 is a key drug target for the development of antiviral therapeutics. Here, we designed and synthesized a series of small-molecule peptidomimetics with various cysteine-reactive electrophiles. Several co...
Sunflower Trypsin Monocyclic Inhibitor Selected for the Main Protease of SARS-CoV-2 by Phage Display [0.03%]
基于噬菌体展示技术筛选的向日葵凝血酶单环抑制肽对SARS-CoV-2主要蛋白酶的抑制作用研究
Graziele Cristina Ferreira,Verônica de Moraes Manzato,Debora Noma Okamoto et al.
Graziele Cristina Ferreira et al.
Main protease (Mpro), also known as 3-chymotrypsin-like protease (3CLpro), is a nonstructural protein (NSP5) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the cleavage of virus polyproteins during viral rep...
Evaluation of inhibition effect and interaction mechanism of antiviral drugs on main protease of novel coronavirus: Molecular docking and molecular dynamics studies [0.03%]
抗新冠病毒主要蛋白酶的小分子抑制剂筛选及作用模式研究：分子对接和分子动力学模拟
Xin Gao,Cuihong Wang,Yue Jiang et al.
Xin Gao et al.
The outbreak of pneumonia caused by the novel coronavirus (SARS-CoV-2) has presented a challenge to public health. The identification and development of effective antiviral drugs is essential. The main protease (3CLpro) plays an important r...
Investigating the Inhibition of Diindolylmethane Derivatives on SARS-CoV-2 Main Protease [0.03%]
二吲哚甲烷衍生物抑制SARS-CoV-2主要蛋白酶的初步研究
Wenjin Li,Xiaoyu Chang,Hang Zhou et al.
Wenjin Li et al.
The SARS-CoV-2 main protease (Mpro) is an essential enzyme that promotes viral transcription and replication. Mpro conserved nature in different variants and its nonoverlapping nature with human proteases make it an attractive target for th...
In silico analysis of balsaminol as anti-viral agents targeting SARS-CoV-2 main protease, spike receptor binding domain and papain-like protease receptors [0.03%]
计算分析白柳素作为针对SARS-CoV-2主要蛋白酶、刺突受体和半胱氨酸利特罗肽类似结构域的抗病毒药物的效果
Daniel Danladi Gaiya,Aliyu Muhammad,Joy Sim Musa et al.
Daniel Danladi Gaiya et al.
Plant-derived phytochemicals from medicinal plants are becoming increasingly attractive natural sources of antimicrobial and antiviral agents due to their therapeutic value, mechanism of action, level of toxicity and bioavailability. The co...
Discovery of Fluorescent Naturally-occurring Inhibitor of SARS-CoV-2 Main Protease By AIE Fluorescent Probe [0.03%]
利用AIE荧光探针发现SARS-CoV-2主要蛋白酶的天然抑制剂
Chong-Jing Zhang,Hao Lin
Chong-Jing Zhang
Target-based high-throughput screening (HTS) is an efficient way to identify potent drugs. However, the accuracy of HTS could be affected by Pan-Assay Interference Compounds (PAINS). One reason for the generation of PAINS is that the inhere...
Computational Insights into SARS-CoV-2 Main Protease Mutations and Nirmatrelvir Efficacy: The Effects of P132H and P132H-A173V [0.03%]
计算揭示新冠病毒主要蛋白酶突变及奈玛特韦的疗效：P132H与P132H-A173V突变的影响
Yuan-Ling Xia,Wen-Wen Du,Yong-Ping Li et al.
Yuan-Ling Xia et al.
Nirmatrelvir, a pivotal component of the oral antiviral Paxlovid for COVID-19, targets the SARS-CoV-2 main protease (Mpro) as a covalent inhibitor. Here, we employed combined computational methods to explore how the prevalent Omicron varian...
Structural basis of rosmarinic acid inhibitory mechanism on SARS-CoV-2 main protease [0.03%]
鼠李素酸抑制SARS-CoV-2主要蛋白酶的机制及其结构基础
Qianhui Li,Xuelan Zhou,Weiwei Wang et al.
Qianhui Li et al.
The SARS-CoV-2 coronavirus is characterized by high mutation rates and significant infectivity, posing ongoing challenges for therapeutic intervention. To address potential challenges in the future, the continued development of effective dr...
Cheng Zhao,Yi Rong,Shuyuan Shi et al.
Cheng Zhao et al.
The SARS-CoV-2 main protease (Mpro) plays a crucial role in virus amplification and is an ideal target for antiviral drugs. Currently, authentic Mpro is prepared through two rounds of proteolytic cleavage. In this method, Mpro carries a sel...
耗时 0.10256 秒，为您在
48206918
条记录里面共找到 83 篇文章 [XML]