Which trials do we need? A pragmatic randomized controlled trial on the duration of antibiotic therapy after debridement of midfoot region: fixed duration versus personalized approach [0.03%]
一项关于中足清创后抗生素治疗时程的实用随机对照研究：固定时长与个体化方案
Erlangga Yusuf,Johan Van Laethem,Jorg L de Bruijn et al.
Erlangga Yusuf et al.
A Randomized Controlled Trial Of Antibiotics Targeting Adherent And Invasive Escherichia Coli (Aiec) Vs Placebo In Crohn's Disease: The Teorem Trial [0.03%]
针对克罗恩病中黏附侵袭性大肠杆菌的抗生素治疗的随机对照试验：TEOREM试验
Franck Carbonnel,Nicolas Barnich,Patricia Lepage et al.
Franck Carbonnel et al.
Background: A subset of patients with ileal Crohn's disease (CD) are colonized with Adherent-invasive Escherichia coli (AIEC). Objective: ...
Exploring the systemic impacts of urinary tract infection-specific antibiotic treatments on the gut microbiome, metabolome, and intestinal morphology in rats [0.03%]
探究尿路感染特异性抗生素治疗对大鼠肠道菌群、代谢组及肠形态的系统性影响
Hao Guo,Xiang Zhou,Zhou Li et al.
Hao Guo et al.
The gut microbiota is a dynamic ecosystem that plays a crucial role in host metabolism, immune system regulation, and protection against pathogens. An imbalanced gut microbiota has been associated with various diseases such as inflammatory ...
Comparison of Seven-Day Versus Continuous Prophylactic Antibiotic Therapy Until Delivery in Preterm Premature Rupture of Membranes [0.03%]
比较七日与持续性预防性抗生素治疗在胎膜早破患者中的效果直至分娩
Guddad Shabana Hameed,Shobha Shirgur,Mallanagouda Patil et al.
Guddad Shabana Hameed et al.
Background and aim Preterm prelabour rupture of membranes (PPROM) refers to the spontaneous rupture of fetal membranes before the onset of labor and prior to 37 completed weeks of gestation. PPROM is associated with significant maternal and...
Cystic Fibrosis Microbiome-directed Antibiotic Therapy Trial in Exacerbations Results Stratified (CFMATTERS): Results of a multi-centre randomised controlled trial [0.03%]
囊性纤维化急性加重期肠道微生态指导的抗生素治疗多中心随机对照试验(CF MATTTERS)：分层结果分析
Barry J Plant,Gisli G Einarsson,Kevin F Deasy et al.
Barry J Plant et al.
Background: This study explores the effectiveness and safety of microbiome-directed-antimicrobial-therapy versus usual-antimicrobial-therapy in adult cystic fibrosis pulmonary exacerbations. ...
Agnieszka Klama-Baryła,Anna Sitkowska,Ewa Tomanek et al.
Agnieszka Klama-Baryła et al.
Objective: The antibacterial properties of amniotic membranes are the reason for their wide clinical use. Amniotic membrane soaked in antibiotics can be used in local antibiotic therapy, creating new options for the treat...
Comparison of in vitro antimicrobial susceptibility between mucoid and non-mucoid Pseudomonas aeruginosa and its guiding value for antibiotic therapy [0.03%]
黏液型和非黏液型铜绿假单胞菌体外药敏比较及其指导抗菌治疗的价值分析
Yun Wu,Aixin Wang,Jinghan Qu et al.
Yun Wu et al.
The aim of the study was to compare in vitro antimicrobial susceptibility between mucoid and non-mucoid Pseudomonas aeruginosa and its guiding value for antibiotic therapy. A retrospective review was conducted on the sources of isolates, pa...
Comparative evaluation of long-term ophthalmic sequelae following first versus second-line antibiotic treatment for congenital syphilis [0.03%]
二线抗生素治疗先天性梅毒后的眼部后遗症长期比较评估
Samuel Montenegro Pereira,Maria Alix Leite Araújo,Rian Vilar Lima et al.
Samuel Montenegro Pereira et al.
Purpose: Congenital syphilis (CS) is associated with interstitial keratitis, chorioretinitis, uveitis, and optic atrophy mainly in inadequately treated patients. We conducted a retrospective cohort analysis evaluating ocu...
Differences in antimicrobial resistance gene abundance and microbial diversity of the gut microbiome in patients on antibiotics enrolled in a clinical trial [0.03%]
临床试验中接受抗生素治疗的患者肠道微生物抗微生物药物耐药基因丰度和微生物多样性的差异性分析
Adam G Stewart,Patrick N A Harris,Rikki M A Graham et al.
Adam G Stewart et al.
Background: Understanding how the gut microbiome adapts on exposure to individual antibiotics, with respect to antimicrobial resistance gene (ARG) enrichment, is important. ...
Risk factors and outcomes of inadequate empirical antibiotic therapy in ventilator-associated pneumonia: a systematic review and meta-analysis [0.03%]
关于呼吸机相关性肺炎经验性抗菌治疗不足的危险因素及结局的系统评价和 meta 分析
Alina Tariq,Theodosios Kantas,Bundhoo Beebee Shabneeze et al.
Alina Tariq et al.
Objectives: Inadequate empirical antibiotic therapy for ventilator-associated pneumonia (VAP) is defined as at least one bacterial isolate not covered by initial antibiotics, or when the bacteria were resistant to all emp...
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