Anxiolytic Effects of Cichorium intybus L. Oligo-Polysaccharides by Modulating Gut Microbiota, Neuronal Signaling Pathways, and Neuroinflammation in Chronic Sleep Deprivation-Stressed Mice [0.03%]
Yongzhi Zhao,Yiwen Zhang,Yanqin Luo et al.
Yongzhi Zhao et al.
This research examined the anxiolytic properties of JSO in a murine model subjected to chronic sleep deprivation (CSD) stress and explored the mechanisms behind this effect, providing experimental evidence for the development of Cichorium intybus L. as a functional food.
Possible Anxiolytic Effects of Cannabidiol (CBD) Administration on Feline Responses to a Fear Response Test [0.03%]
Nobuo Masataka
Nobuo Masataka
In humans, cannabidiol (CBD), the primary non-addictive component of cannabis, is known to possess considerable therapeutic potential. The purpose of this study was to investigate the effects of CBD administration on reducing sound-induced ...
Dual Mechanisms of the Diazepine-Benzimidazole Derivative, DAB-19, in Modulating Glutamatergic Neurotransmission [0.03%]
DAB-19二氮杂苯并咪唑衍生物调节谷氨酸神经传递的双重机制研究
Maxim V Nikolaev,Irina M Fedorova,Oxana V Chistyakova et al.
Maxim V Nikolaev et al.
Recently, the diazepine-benzimidazole derivative, DAB-19, has emerged as a promising candidate due to its demonstrated anxiolytic and analgesic effects.
Daily Administration of Agmatine Reduced Anxiety-like Behaviors and Neural Responses in the Brains of Male Mice with Persistent Inflammation in the Craniofacial Region [0.03%]
每日给予_agmatine_可减轻小鼠颅面区域持续性炎症引起的类焦虑行为及大脑神经反应
Yuya Iwamoto,Kajita Piriyaprasath,Andi Sitti Hajrah Yusuf et al.
Yuya Iwamoto et al.
Notably, preventive agmatine did not affect general locomotor activity (indicated by total movement distance), indicating that its anxiolytic effects were not confounded by altered locomotor activity.
ML184 influences coping strategies via GPR55-dependent mechanisms following its delivery in the periaqueductal gray (PAG) region [0.03%]
ML184通过第三脑室注射在导水管周围灰质区域影响应对机制的策略取决于GPR55依赖性机制
Carlos H López-Lariz,Bruno A Marichal-Cancino
Carlos H López-Lariz
Moreover, ML184 may induce anxiolytic effects and higher-rearing behaviors by GPR55-independent mechanisms (which remain to be identified).
Astrocytic modulation of GABA transmission in the VTA limits progression of anxiety- and depression-like behaviors in adult mice [0.03%]
成年小鼠中脑腹侧被盖区星形胶质细胞调控GABA能传递限制焦虑和抑郁样行为的进展
Jun Du,Huapeng Diao,Yaling Xu et al.
Jun Du et al.
Optogenetic VTA astrocyte activation disinhibits dopaminergic neurons via presynaptic adenosine A1 receptors on GABAergic interneurons, producing anxiolytic and antidepressant effects.
Trends in Utilization of Services for Mental Health and Substance Use Disorders Before and After Bariatric Surgery [0.03%]
术前和术后用于精神健康和物质使用障碍服务利用的趋势变化
Abigail J Alexander,Rebecca M Empey,Joshua John Horns et al.
Abigail J Alexander et al.
rate ratio from the pre- to-post-surgical period for inpatient psychiatric encounters (1.721 (1.481-2.00)), community mental health visits (1.325 (1.005-1.748)), outpatient psychiatrist visits (1.311 (1.255-1.37)), therapist visits (1.281(1.233-1.341)), antidepressant refills (1.154 (1.139-1.169)) and anxiolytic
Study of micro-signals: proposed analysis methodology based on data from the Lille Poison Control and Toxicovigilance Center [0.03%]
微弱信号的研究：基于里尔中毒控制和毒物监测中心数据的分析方法探讨
Tracy Lurant,Anne Garat,Emma Nemesien et al.
Tracy Lurant et al.
It highlighted the effect of national measures on the use of an anxiolytic that had not been detected by the teams at the time.
Nociceptin/Orphanin FQ receptor agonism attenuates behavioral and neural responses to conditioned aversive stimuli [0.03%]
阿片肽受体激动剂减缓了厌恶条件刺激的行为和神经反应
Kwang-Hyun Hur,Diego A Pizzagalli,Jessi Stover et al.
Kwang-Hyun Hur et al.
The nociceptin/orphanin FQ peptide (NOP) receptor has emerged as a promising anxiolytic target, as its activation has been shown to reduce anxiety-related behaviors in rodents. However, the mechanisms underlying these effects are not well understood.
A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing [0.03%]
一项关于血清素系统与情绪处理相互作用的大型多模态研究
Manfred Klöbl,Matej Murgaš,Murray Bruce Reed et al.
Manfred Klöbl et al.
We interpret our findings on multiple levels of the serotonergic-emotional interaction within the context of enhanced passive coping and acute anxiolytic effects of citalopram following potential changes in serotonin or SERT availability.
Randomized Controlled Trial
Translational psychiatry. 2025 Jun 11;15(1):196. DOI:10.1038/s41398-025-03407-2 2025
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