Hydroxycarboxylic Acid Receptor 2 Mediates β-hydroxybutyrate's Antiseizure Effect in Mice [0.03%]
β-羟基丁酸抗惊厥作用的介导受体及机制研究
Soudabeh Naderi,John Williamson,Huayu Sun et al.
Soudabeh Naderi et al.
Objective: The ketogenic diet, a high-fat, low-carbohydrate regimen, is often used to treat drug-resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism...
Anticonvulsant Activity of 12-Epinapelline N-Oxide, a Diterpene Alkaloid of the Atisine Series [0.03%]
12-环氧奈波林诺氧化物(一种阿提辛型倍半萜生物碱)的抗惊厥作用
Yu V Nesterova,O V Vsyakikh,T N Povetyeva et al.
Yu V Nesterova et al.
The anticonvulsant activity of the diterpene alkaloid 12-epinapelline N-oxide isolated from the aboveground part of Aconitum baicalense was demonstrated in experiments on mice with modeled maximal electroshock-induced seizure and pentylenet...
Antiseizure Effects of Mirtazapine in a Rat Model of Status Epilepticus Via Cannabinoid Receptor Modulation [0.03%]
犬尿酸途径调节剂米塔扎平的抗惊厥作用及机制研究
Ali Vafaei,Mohammad Amin Manavi,Samaneh Toutounchian et al.
Ali Vafaei et al.
Status epilepticus (SE) is a severe neurological condition with high morbidity and mortality rates. Despite the availability of treatments, many cases remain refractory to standard therapies. In this study we investigated the possible antic...
Ferulic Acid Attenuates Seizure Severity and Enhances Valproate and Carbamazepine Seizure Preventing Efficacy by Regulating Hippocampal Interleukin-1β Level and Antioxidant Capacity in Mice [0.03%]
金丝桃素减轻小鼠癫痫发作严重程度并增强丙戊酸钠和卡马西平抗惊厥作用：海马细胞因子IL-1β及抗氧化能力的调节作用
Elaheh Taheri,Majid Hassanpourezatti
Elaheh Taheri
Epilepsy is a neurological brain disease characterized by multiple seizures with short intervals and becomes drug-resistant when it causes oxidative stress and inflammation in the brain. Ferulic acid (FA) is a plant phenolic substance with ...
Different mechanisms of axitinib and diazepam antiseizure action in pentylenetetrazol-induced kindling model [0.03%]
阿維魯宗和地西泮在戊四唑诱导的痫灶模型中不同抗惊厥作用机制研究
Leonid S Godlevsky,Işınsu Alkan,Kıymet Kübra Tüfekci et al.
Leonid S Godlevsky et al.
Introduction: This study intended to assess the histomorphology characteristics of hippocampal structures and determine the severity of seizures after treatment with the tyrosine kinase B inhibitor axitinib and diazepam i...
Replication of seizure-suppressing effects of alpha-linolenic acid on the Drosophila melanogaster para Shudderer mutant [0.03%]
α-亚麻酸在果蝇para突变体中抗惊厥作用的验证
Samantha Dinnel,Brady Weimer,Allyson Davis et al.
Samantha Dinnel et al.
Voltage-gated sodium channels are essential for healthy nervous system function. Mutations in voltage-gated sodium channels are associated with a range of seizure conditions. The genetics of seizure conditions are complex and often challeng...
Preclinical assessment of pharmacokinetics and anticonvulsant activity of CBDTech, a novel orally administered cannabidiol (CBD) formulation for seizure and epilepsy [0.03%]
一种新型口服大麻二酚(CBD)制剂CBDTech的药代动力学和抗惊厥作用的临床前评估
Jacob D McDonald,Feng Zhou,Justyna Kulpa et al.
Jacob D McDonald et al.
Oral cannabidiol (CBD) product use is increasing despite suboptimal pharmacokinetics (PK) of currently available formulations. This study aimed to investigate the PK of CBD formulated using the drug delivery technology DehydraTECH™, which ...
Lacosamide as a chemoprotective agent beyond anticonvulsant activity: Pharmacological modulation of Notch-1/NF-κB axis to restore antioxidant defense, inhibit apoptosis, and preserve testosterone-androgen receptor signaling in cyclophosphamide-induced prostate injury [0.03%]
拉考沙胺的化学保护作用超出了抗惊厥作用：通过药理学调节Notch-1/NF-κB轴恢复抗氧化防御，抑制细胞凋亡并保持环磷酰胺引起的前列腺损伤中的睾酮-雄激素受体信号传导
Mohammed R A Ali,Basim A S Messiha,Ahmed S Abdel-Samea et al.
Mohammed R A Ali et al.
Cyclophosphamide (CPX)-induced prostatic toxicity remains a clinically relevant concern, with limited strategies available to mitigate its adverse effects. This study investigates the potential protective effects of lacosamide (LCS), an FDA...
The anticonvulsant activity of trace amine-associated receptor 1 (TAAR1) agonists involves GABAB receptors in mice [0.03%]
痕量胺相关受体1(TAAR1)激动剂的抗惊厥作用涉及小鼠GABAB受体
Misato Yoshikawa,Miki Fukugami,Katsuya Suemaru
Misato Yoshikawa
Trace amine-associated receptor 1 (TAAR1) agonists have shown potential as therapeutic agents for schizophrenia and other neuropsychiatric disorders. However, it remains unclear whether TAAR1 agonists have anticonvulsant activity. We theref...
Evaluation of the Potential Anticonvulsant and Neuroprotective Effects of Ganoderma Lucidum Extract in an Animal Model of Pentylenetetrazol-Induced Seizures [0.03%]
灵芝提取物抗惊厥和神经保护作用的动物模型评估：戊四唑诱导的癫痫模型研究
Itto Rahou Abdessamad,El-Hessni Aboubaker,Bahbiti Youssef et al.
Itto Rahou Abdessamad et al.
Ganoderma lucidum extract (GLE) has neuro-therapeutic and anticonvulsant effects. This study aimed to evaluate the potential neuroprotective and antioxidant effects of ethanolic extract on pentylenetetrazol-induced brain damage in male Wist...
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