Development of an ensemble prediction model for acute graft-versus-host disease in allogeneic transplantation based on machine learning [0.03%]
基于机器学习的异基因移植急性移植物抗宿主病列队预测模型构建
Lin Song,Xingwei Wu,Mengjia Xu et al.
Lin Song et al.
Background: Acute graft-versus-host disease (aGVHD) is a major post-transplantation complication and one of the most significant causes of non-relapse-related death. However, the massive and complex clinical data make aGV...
Salvage treatment of steroid-refractory acute GVHD with the off-the-shelf product of human umbilical cord mesenchymal stromal cells: a multicenter, open label, phase Ib/IIa trial [0.03%]
利用即用型人脐带间充质基质细胞产品治疗糖皮质激素难治性急性移植物抗宿主病的补救疗法：一项多中心、开放标签Ib/II期临床试验
Yanmin Zhao,Yi Luo,Jimin Shi et al.
Yanmin Zhao et al.
Background: Acute graft-versus-host disease (aGVHD) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), particularly if treatment is refractory. Mesenchymal stromal cel...
Management of infection and ocular complications in pediatric SJS/TEN-like acute graft-versus-host disease: a clinical case study and literature review [0.03%]
儿童SJS / TEN样急性移植物抗宿主病感染和眼并发症的管理：临床病例研究与文献回顾
Huimin Yan,Yunjun Mo,Yue Li et al.
Huimin Yan et al.
Acute graft-versus-host disease (aGVHD) with skin manifestations reminiscent of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) is associated with poor outcomes. However, optimal management strategies to enhance quality ...
Donor macrophage pyroptosis contributes to the development of aGVHD [0.03%]
捐体巨噬细胞的pyroptosis参与了急性移植物抗宿主病的发展
Xueyan Sun,Qingyuan Qu,Qi Chen et al.
Xueyan Sun et al.
Pyroptosis, a novel form of inflammation-related programmed cell death that often occurs in myeloid cells, plays an important role in multiple inflammatory diseases. Our previous study revealed macrophage dysfunction in acute graft-versus-h...
A single dose of a CD137 antibody-drug conjugate protects nonhuman primate allogeneic HCT recipients against acute GVHD [0.03%]
单剂量CD137抗体药物偶联物可保护非人灵长类动物同种异体造血细胞移植受者免于急性移植物抗宿主病
Ulrike Gerdemann,Kyle Kimler,Matthew R Warren et al.
Ulrike Gerdemann et al.
Rapid CD137 upregulation on alloreactive T-cells upon allogeneic stimulation suggests that their selective elimination could prevent acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (HCT). Her...
The donor genetic determinant of human thymopoiesis rs2204985 is associated with acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients [0.03%]
供者基因多态性rs2204985通过调控同种异体造血干细胞移植受者的胸腺输出与急性移植物抗宿主病相关
Lucas C M Arruda,Ahmed Gaballa,Marie Schaffer et al.
Lucas C M Arruda et al.
The rs2204985 single-nucleotide genetic polymorphism is a common genetic variant located within the T-cell receptor locus that influences thymopoiesis, with the GG genotype presenting higher thymic function than AA counterparts. Recent repo...
Ruxolitinib treatment outcomes in acute graft-versus-host disease (aGvHD) in a real-world setting in Finland [0.03%]
鲁索利替尼治疗芬兰真实世界急性移植物抗宿主病（aGvHD）的疗效
Eeva Martelin,Arttu Kuikka,Hanna Rajala et al.
Eeva Martelin et al.
Recombinant human thrombopoietin reduces the risk of acute graft-versus-host-disease and its mechanism [0.03%]
重组人血小板生成素可降低急性移植物抗宿主病风险及其机制研究
Hairong Fei,Xiaodan Liu,Xiaolin Ma et al.
Hairong Fei et al.
Objective: Acute graft-versus-host disease (aGVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study aimed to evaluate the effect of recombinant human thrombopoietin (...
Multiomics profiles of genome-wide alterations in H3K27ac in different lung lobes after acute graft- versus-host disease with MSCs treatment [0.03%]
急性移植物抗宿主病不同肺叶H3K27ac基因组范围改变的多组学谱型及间充质干细胞治疗后变化规律研究
Zixuan Lu,Yuming Zhou,Chengyu Li et al.
Zixuan Lu et al.
The molecular characteristics of acute graft-versus-host disease (aGVHD) in different lung lobes and the treatment of aGVHD with mesenchymal stem cells are still poorly understood. In addition, despite the important role of acetylation on l...
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