A salophen-type macrocyclic Schiff base ligand and its metal complexes: exploring in vitro anticancer efficacy via in silico topoisomerase IIβ enzyme targeting [0.03%]
一类含氮杂环辛四烯类席夫碱及其金属配合物的合成与表征及体外抗肿瘤活性研究
Monika Yadav,Deepak Yadav,Dharam Pal Singh et al.
Monika Yadav et al.
Cancer persists as a principal cause of global mortality. Despite significant progress in cancer therapeutics in recent decades, chemotherapy remains a primary modality for cancer treatment. Based on their mechanism of action, commonly used...
Expression and Characterization of L-Arabinose Isomerase and Its Enzymatic Recycling of the Expired Milk [0.03%]
L-阿拉伯糖异构酶的表达及其对过期牛奶的酶法转化研究
Zhou Chen,Yuhan Yan,Ziang Wu et al.
Zhou Chen et al.
As global milk production continues to rise, the disposal of expired milk contributes to environmental pollution and valuable resource wastage. This study presents the development of a novel L-arabinose isomerase, designated BmAIase12, and ...
Comparison of Two l-Arabinose Isomerases for Multienzymatic Conversion of Lactose in Skim Milk Permeate at Neutral and Acidic pH [0.03%]
skim milk 渗透液中于中性及酸性 pH 下用于乳糖多酶法转化的两种 d-阿拉伯糖异构酶性能比较
Nathanael Weber,Sabine Lutz-Wahl,Lutz Fischer
Nathanael Weber
The sweetness of dairy byproducts can be increased by hydrolysis of lactose to d-glucose and d-galactose and subsequent isomerization to d-fructose and d-tagatose. The isomerization of d-galactose to d-tagatose in skim milk ultrafiltration ...
Structural insight in understanding the impact of mutation at position 88 and 94 of DNA gyrase A of Mycobacterium tuberculosis in developing resistance against delafloxacin [0.03%]
从结构角度理解Rv3561c（DNA回旋酶A）中第88和第94位点突变对分枝杆菌德拉氟欣耐药性影响的机制研究
Sumit Kumar Rai,Dev Bukhsh Singh,Satendra Singh
Sumit Kumar Rai
DNA gyrase is a target for treating tuberculosis caused by Mycobacterium tuberculosis. Many cases of antibiotic resistance have been reported due to different point mutations in the Chain A of DNA gyrase. Based on literature information on ...
Amos Olalekan Akinyemi,Josias da Silveira Rocha,Gabriela Porto de Oliveira et al.
Amos Olalekan Akinyemi et al.
DNA topoisomerases, particularly type II, are crucial for DNA processes, such as replication, transcription, and chromosome segregation, making them prime targets for cancer therapy. This review delves into the multifaceted mechanisms of ac...
Engineering Saccharomyces Cerevisiae With Novel Functional Xylose Isomerases From Rumen Microbiota for Enhanced Biofuel Production [0.03%]
工程改造酿酒酵母表达反刍动物瘤胃微生物来源的新型功能型木糖异构酶以增强生物燃料产量
Beatriz de Oliveira Vargas,Marcelo Falsarella Carazzolle,Juliana Pimentel Galhardo et al.
Beatriz de Oliveira Vargas et al.
Xylose metabolism in Saccharomyces cerevisiae remains a significant bottleneck due to the difficulty in identifying functional and efficient xylose isomerases (XI). In the present study, publicly available metagenomic and metatranscriptomic...
Construction of hyperthermostable d-allulose 3-epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus [0.03%]
利用Arthrobacter psychrolactophilus的序列信息构建超热稳定的D-全阿洛糖3-差向异构酶（来源于微球菌M30）
Kensaku Shimada,Kouhei Ohtani,Pushpa Kiran Gullapalli et al.
Kensaku Shimada et al.
d-Allulose is one of the rare monosaccharides and is considered as a safe ingredient in foods. It can be enzymatically produced from d-fructose by the enzyme d-allulose 3-epimerase. More stable enzymes can operate effectively for longer dur...
D-tagatose biotransformation from lactose by lactase and recombinant Bacillus subtilis expressing l-arabinose isomerase, and the product separation, purification and crystallization [0.03%]
以乳糖为底物转化d-塔格糖的研究及产物的分离提纯结晶
Xin Wen,Huibin Lin,Guangwen Liu et al.
Xin Wen et al.
d-Tagatose is a low-calorie rare sugar with notable physiological benefits. The recombinant Bacillus subtilis expressing L-arabinose isomerase (LAI) was constructed and used together with lactase for biotransformation of d-tagatose from che...
Discovery of novel thiazolopyrimidine derivatives targeting topoisomerase II: Design, synthesis, antiproliferative evaluation, molecular docking and apoptosis inducing activity [0.03%]
新型噻唑并吡啶衍生物靶向拓扑异构酶II的发现：设计、合成、抗增殖评价、分子对接及诱导凋亡活性研究
Sara Y Ewieda,Mo&#x;men Salem,Ahmed Elshewy et al.
Sara Y Ewieda et al.
Two new sets of thiazolopyrimidines IIa-h, IVa-d were designed, synthesized, and screened for their anticancer activity against MCF-7 breast cancer adenocarcinoma, HCT116 colorectal cancer, and HepG2 hepatic cancer. The safety of the newly ...
The low endoribonuclease activity and lack of rNMP preference of human mitochondrial topoisomerase 1 protect against ribonucleotide-dependent deletions [0.03%]
人线粒体拓扑异构酶1的低内切核糖核酸酶活性和缺乏rNMP偏好性可防止依赖于核糖核苷酸的缺失现象
Cyrielle P J Bader,Erika Miyazaki-Kasho,Josefin M E Forslund et al.
Cyrielle P J Bader et al.
The incorporation of ribonucleotides (rNMPs) into the nuclear genome leads to severe genomic instability, including strand breaks and short 2-5 bp deletions at repetitive sequences. Curiously, the detrimental effects of rNMPs are not observ...
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