Plant-derived nodule-specific cysteine-rich peptides as potent antifungal agents against Cryptococcus neoformans: mechanisms of action, chimeric peptide enhancement, and immunomodulatory effects [0.03%]
来源于植物的结节特异性半胱氨酸丰富多肽作为抗新生隐球菌的强大抗真菌剂：作用机制、嵌合肽增强和免疫调节效应
Bettina Szerencsés,Csaba Papp,Alexandra Pál et al.
Bettina Szerencsés et al.
The basidiomycetous yeast Cryptococcus neoformans is classified among the four critical fungal pathogens due to its capability of inducing life-threatening meningitis in immunocompromised individuals, particularly AIDS patients. The increas...
GLP-1 receptor agonist properties of a chimeric peptide derived by hybridization of Latrodectus αLatrotoxin and Heloderma Exendin-4 [0.03%]
一种嵌合多肽的胰高血糖素样肽-1受体激动活性：此多肽由美洲箭毒蜘蛛α-大毒素与蛤蚧石龙子衍生的外源素-4杂交而成
Oleg G Chepurny,Amber N Liles,Nancy Cham et al.
Oleg G Chepurny et al.
Chimeric peptides comprised of amino acid sequence motifs found within hormones, neuropeptides, and insect or lizard toxins are now under investigation for their potential use in therapeutics. Here, we report the discovery of one such pepti...
Evaluation of the antimicrobial efficiency of three novel chimeric peptides through biochemical and biophysical analyses [0.03%]
通过生化和生物物理分析评估三种新型嵌合肽的抗菌效率
Brandt Bertrand,Carmen Itzamatul Rodríguez Alejandro,María Del Carmen Gutiérrez et al.
Brandt Bertrand et al.
Three chimeric membrane-active antimicrobial peptides (AMPs) were designed from previously characterized parental molecules, namely pandinin-2, ascaphin-8, and maximin-3. The aim of constructing these chimeras was to obtain sequences with i...
A novel multi-functional chimeric peptide for enhanced safe gene delivery in immunotherapy [0.03%]
一种用于免疫治疗的多功能嵌合肽增强安全基因传递的新方法
Mahdiyar Dehshiri,Shokouh Rezaei,Saman Hosseinkhani
Mahdiyar Dehshiri
Chimeric peptides hold promising potential to be introduced as an ideal gene delivery platform based on their advantages over viral carriers, including but not limited to the safety profile and specific targeting. However, their gene transf...
The Chimeric Peptide (GEP44) Reduces Body Weight and Both Energy Intake and Energy Expenditure in Diet-Induced Obese Rats [0.03%]
嵌合肽(GEP44)通过减少摄食和产热以外的机制降低肥胖大鼠体重
Matvey Goldberg,James E Blevins,Tami Wolden-Hanson et al.
Matvey Goldberg et al.
We recently reported that a chimeric peptide (GEP44) targeting the glucagon-like peptide-1 receptor (GLP-1R) and neuropeptide Y1- and Y2- receptors decreased body weight (BW), energy intake, and core temperature in diet-induced obese (DIO) ...
Innovative Self-Assembly of 15-Mer Chimeric α-Peptide-Oligourea Foldamers toward Cl--Selective Ion Channels [0.03%]
十五肽-寡脲嵌合折纸肽的创新自组装朝向Cl-选择性离子通道
Chiranjit Dutta,Pannaga Krishnamurthy,Dandan Su et al.
Chiranjit Dutta et al.
Constructing artificial ion channels is a challenging task. Herein, the de novo design of transmembrane ion channels made up of amphiphilic peptide-oligourea chimeric helices is described. They consist of an oligourea segment (7-mer) attach...
Chimeric Peptide Functionalized Immunostimulant to Orchestrate Photodynamic Immunotherapeutic Effect by PD-L1 Deglycosylation and CD47 Inhibition [0.03%]
通过PD-L1脱糖基化和CD47抑制调控光动力免疫治疗效应的杂交肽免疫刺激剂
Yi Cen,Xin-Xuan Li,Min Wang et al.
Yi Cen et al.
Breast cancer utilizes diverse immunosuppressive mechanisms to evade immune surveillance, thereby impairing immunotherapeutic effects. In this work, a chimeric peptide functionalized immunostimulant (designated as aGlyR) is fabricated to bo...
The Chimeric Peptide (GEP44) Reduces Body Weight, Energy Intake, and Energy Expenditure in Diet-Induced Obese Rats [0.03%]
嵌合肽(GEP44)通过减少摄食和产热抑制饮食诱导的肥胖大鼠体重增加
Matvey Goldberg,James E Blevins,Tami Wolden-Hanson et al.
Matvey Goldberg et al.
We recently reported that a chimeric peptide (GEP44) targeting the glucagon-like peptide-1 receptor (GLP-1R) and neuropeptide Y1- and Y2-receptors decreased body weight (BW), energy intake and core temperature in diet-induced obese (DIO) ma...
A Chimeric Peptide for Shielding Plant Photosynthetic Systems against Excess Light Stress via Chloroplast-Targeted ROS Quenching [0.03%]
一种针对叶绿体定位ROS淬灭的嵌合肽用于屏蔽植物光合作用系统以应对过多光线压力
Takaaki Miyamoto,Shamitha Rao Morey-Yagi,Keiji Numata
Takaaki Miyamoto
The ability to quench reactive oxygen species (ROS) overproduced in plant chloroplasts under light stress conditions is essential for securing plant photosynthetic performance and agricultural yield. Although genetic engineering can enhance...
Chimeric Peptide-Engineered Polyprodrug Enhances Cytotoxic T Cell Response by Inducing Immunogenic Cell Death and Upregulating Major Histocompatibility Complex Class I [0.03%]
嵌合肽工程化多前药通过诱导免疫原性细胞死亡和上调主要组织相容性复合体增强细胞毒性T细胞反应
Ying Chen,Yi Cen,Xin-Xuan Li et al.
Ying Chen et al.
Tumor-specific cytotoxic T cell immunity is critically dependent on effective antigen presentation and sustained signal transduction. However, this immune response is frequently compromised by the inherently low immunogenicity of breast can...
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