Dissecting Hidden Liraglutide Oligomerization Pathways via Direct Mass Technology, Electron-Capture Dissociation, and Molecular Dynamics [0.03%]
采用直接质谱技术、电子捕获解离和分子动力学解析利拉鲁肽隐秘寡聚化途径
Syuan-Ting Kuo,Zhenyu Xi,Xiao Cong et al.
Syuan-Ting Kuo et al.
Peptide therapeutics have revolutionized drug design strategies, yet the inherent structural flexibility and conjugated moieties of drug molecules present challenges in discovery, rational design, and manufacturing. Liraglutide, a GLP-1 rec...
Mammarenavirus Z Protein Myristoylation and Oligomerization Are Not Required for Its Dose-Dependent Inhibitory Effect on vRNP Activity [0.03%]
哺乳动物雷尼拉病毒Z蛋白的脂肪酰化和寡聚化不是其剂量依赖性抑制vRNA聚合酶活性所必需的条件
Haydar Witwit,Juan C de la Torre
Haydar Witwit
Background/objectives: N-Myristoyltransferase inhibitors (NMTi) represent a novel antiviral strategy against mammarenaviruses such as Lassa and Junin viruses. The Z matrix protein inhibits viral ribonucleoprotein (vRNP) a...
ATP-inducible Receptor Oligomerization Enables Fine-tuning of T Cell Immunity [0.03%]
可诱导的受体寡聚化使T细胞免疫的微调成为可能
Jianjun He,Haoxiang Li,Fuling Liang et al.
Jianjun He et al.
Receptor oligomerization plays a pivotal role in the regulation of cellular behaviors and functionalities. Stimuli-responsive artificial circuits are often programmed to rewire cell signaling by fine-tuning receptor interactions through tar...
Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation [0.03%]
SARS-CoV-2 N蛋白动态集合体揭示了头对头的螺旋桨驱动聚类和相分离
Guillem Hernandez,Maria L Martins,Nuno P Fernandes et al.
Guillem Hernandez et al.
The SARS-CoV-2 nucleocapsid (N) protein is essential for the viral life cycle, facilitating RNA packaging, replication, and host-cell interactions. Its ability to self-assemble and undergo phase separation is critical for these functions bu...
A histidine switch regulates pH-dependent filament formation by the caspase-9 CARD [0.03%]
组氨酸转换调节半胱天冬酶-9死亡效应结构域的酸驱动寡聚化及细丝形成
Swasti Rawal,Ðesika Kolarić,Stefan Bohn et al.
Swasti Rawal et al.
The caspase activation and recruitment domain (CARD) mediates protein-protein interactions in apoptotic and inflammatory signaling pathways. In humans, more than 30 proteins contain a CARD, several of which have been reported to polymerize ...
Corrigendum to "Supratherapeutic concentrations of cilostazol inhibits β-amyloid oligomerization in vitro" [Neurosci. Lett. 677 (2018) 19-25/ NSL_33555] [0.03%]
有关“西洛他唑超治疗浓度通过抑制β淀粉样蛋白低聚化来改善学习和记忆”一文的勘误(神经科学研究快报)[Neurosci. Lett. 677 (2018) 19-25/ NSL_33555]
Hidenobu Shozawa,Tatsunori Oguchi,Mayumi Tsuji et al.
Hidenobu Shozawa et al.
Published Erratum
Neuroscience letters. 2025 Jun 5:138285. DOI:10.1016/j.neulet.2025.138285 2025
Tau Oligomerization Drives Neurodegeneration via Nuclear Membrane Invagination and Lamin B Receptor Binding in Alzheimer's disease [0.03%]
tau寡聚体通过核膜内陷和Lamin B受体结合驱动阿尔茨海默病神经退行性病变
Nicholas Essepian,Shuo Yuan,Rebecca Roberts et al.
Nicholas Essepian et al.
The microtubule-associated protein tau aggregates into oligomeric complexes that highly correlate with Alzheimer's disease (AD) progression. Increasing evidence suggests that nuclear membrane disruption occurs in AD and related tauopathies,...
Hsp90 C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels [0.03%]
HSP90 C-末端结构域抑制通过破坏GPX4-VDAC1相互作用增强铁死亡并增加HMOX1从寡聚化VDAC1通道的释放
Jieyou Li,Guibing Wu,Hairou Su et al.
Jieyou Li et al.
Hepatocellular carcinoma (HCC) is one of the most common and lethal malignancies worldwide. Given the critical role of liver in iron storage and metabolism, ferroptosis, characterized by iron-dependent lipid peroxidation and oxidative damag...
A coiled-coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor [0.03%]
卷曲螺旋结构域触发分枝杆菌转运蛋白MmpL10的寡聚化作用
Julie Couston,Jérôme Feuillard,Aurélie Ancelin et al.
Julie Couston et al.
The mycobacterial outer membrane is composed of unusual lipids and glycolipids. Some of these lipids are exported to the cell envelope by resistance-nodulation-division (RND) transporters called mycobacterial membrane protein large (MmpL). ...
A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization [0.03%]
Polycomb蛋白Polyhomeotic中的无序连接结构域调控相分离和寡聚化
Tim M Gemeinhardt,Roshan M Regy,Tien M Phan et al.
Tim M Gemeinhardt et al.
Biomolecular condensates are increasingly recognized as key regulators of chromatin organization, yet how their formation and properties arise from protein sequences remains incompletely understood. Cross-species comparisons can reveal both...
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