A Novel RORA Genetic Variant Associated with Early-Onset Obesity and Insomnia [0.03%]
与早发性肥胖和失眠相关的新RORA基因变异体
Alexie Ouellette,Eric P Allain,Abdullah Almaghraby et al.
Alexie Ouellette et al.
Retinoic acid-related orphan receptor alpha (RORA) pathogenic variants cause intellectual developmental disorder with or without epilepsy or cerebellar ataxia (IDDECA). Herein, we present a female patient with a novel heterozygous likely pa...
Dynamic Functional Connectivity Differences Between Insomnia and Comorbid Insomnia with Depression: A Neuroimaging Study of Brain Stability [0.03%]
失眠与抑郁共病性失眠的大脑稳定性差异：一项动态功能连接的神经影像学研究
Zhangwei Lv,Haobo Zhang,Yuhan Fan et al.
Zhangwei Lv et al.
Previous studies have shown a complex, possibly bidirectional relationship between insomnia disorder (ID) and major depressive disorders (MDD). Neuroimaging evidence suggests the different functional connectivity (FC) of the ID and MDD pati...
Prevalence of and factors associated with clinically important levels of fatigue, pain, and insomnia in survivors of cancer: a population-based cross-sectional study [0.03%]
癌症幸存者临床意义疲劳、疼痛和失眠的患病率及影响因素：一项基于人群的横断面研究
Anne Katrine Graudal Levinsen,Susanne Oksbjerg Dalton,Erik Jakobsen et al.
Anne Katrine Graudal Levinsen et al.
Purpose: To identify risk factors and patient characteristics in survivors who report clinically important fatigue, pain, and insomnia. Methods: ...
Kleine-Levin syndrome: mixed episodes with both hypersomnia and insomnia as a marker of severity [0.03%]
克莱恩-莱文综合征：既是疾病严重标志的睡眠过多和失眠交替发作作为一种标记物的重要性
Saba Al-Youssef,Pauline Dodet,Elisabeth Groos et al.
Saba Al-Youssef et al.
Efficacy and Safety of Hormone Replacement Combined With Escitalopram in the Treatment of Chronic Insomnia in Perimenopausal Women: A Randomized Controlled Trial [0.03%]
激素替代治疗联合艾司西酞普兰治疗围绝经期慢性失眠的疗效及安全性研究：随机对照试验
Hui Chen,Shufang Wu,Hongbin Chen et al.
Hui Chen et al.
Aims: To explore the efficacy of Femoston plus escitalopram for perimenopausal women with chronic insomnia and the relevant biomarkers. Methods: ...
Randomized Controlled Trial
CNS neuroscience & therapeutics. 2025 Jun;31(6):e70470. DOI:10.1111/cns.70470 2025
Outcome of Sleep Rehabilitation in Autistic Children with Sleep Disorders Is Linked to Melatonin Receptor Genes SNPs [0.03%]
褪黑素受体基因多态性影响自闭症伴发失眠儿童睡眠康复的效果
Elisabetta Bolognesi,Alessandra Carta,Franca Rosa Guerini et al.
Elisabetta Bolognesi et al.
A significant proportion of children with Autism spectrum disorder (ASD) experience sleep issues, such as insomnia and other disorders, as assessed by the Sleep Disturbance Scale for Children. Our study investigated the link between six sin...
The Association of Insomnia with Febrile Neutropenia, Leucopenia, and Infection in Women Receiving Adjuvant Chemotherapy for Breast Cancer [0.03%]
失眠与接受辅助化疗的乳腺癌女性发热性中性粒细胞减少，白细胞减少和感染的相关性研究
Audreylie Lemelin,Josée Savard,Michelle Chen et al.
Audreylie Lemelin et al.
Background/Objectives: Insomnia is associated with immune function. This study evaluated the association between insomnia and febrile neutropenia in women treated with adjuvant chemotherapy for breast cancer. Methods: This secondary analysi...
Integrating traditional Chinese medicine constitutions into insomnia management: Findings from a cross-sectional study [0.03%]
基于横断面研究的结果融入传统中医体质的失眠管理
Yan Han,Yu Wang,Mo-Yi Shi et al.
Yan Han et al.
Objective: The concept of constitution in traditional Chinese medicine (TCM) has been increasingly recognized as a crucial factor in both the prevention and treatment of insomnia. However, rigorous statistical evidence on...
Automated Insomnia Phenotyping from Electronic Health Records: Leveraging Large Language Models to Decode Clinical Narratives [0.03%]
基于电子健康记录的自动化失眠分型：利用大型语言模型解码临床叙述
Guillermo Lopez-Garcia,Davy Weissenbacher,Matthew Stadler et al.
Guillermo Lopez-Garcia et al.
Insomnia is a highly prevalent but often underdiagnosed condition in clinical practice. Its inconsistent documentation in electronic health records (EHRs) limits population-level analyses and obstructs efforts to evaluate treatment patterns...
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