Plantaginis Herba attenuates adriamycin-induced nephropathy: Molecular mechanism insights by integrated transcriptomic and experimental validation [0.03%]
丹参防治阿霉素肾病的机制研究：整合转录组和实验验证
Beibei Zhang,Mengnan Zeng,Ru Wang et al.
Beibei Zhang et al.
Ethnopharmacological relevance: The Chinese herbal Plantaginis Herba (PL) is one of the most widely used plants for both medicinal and dietary purposes. Plantaginis Herba is the main medicine used in a traditional Chinese...
The Role and Mechanism of Perilla Alcohol in Counteracting Doxorubicin-Induced Nephrotic Syndrome [0.03%]
紫苏醇抗阿霉素致神经病变的作用及机制研究
Mingjing Liu,Shen Li,Peimin Hou
Mingjing Liu
Background: Doxorubicin (DOX) is a widely used anticancer drug; However, its nephrotoxicity limits its therapeutic efficacy. This study investigates the protective effects of Perilla Alcohol (PA) against DOX-induced nephr...
Development and Characterization of a Novel FVB- PrkdcR2140C Mouse Model for Adriamycin-Induced Nephropathy [0.03%]
一种新颖的FVB-PrkdcR2140C小鼠模型用于多柔比星肾病的发展与表征
Masaki Watanabe,Yuki Ishii,Kazuki Hashimoto et al.
Masaki Watanabe et al.
The Adriamycin (ADR) nephropathy model, which induces podocyte injury, is limited to certain mouse strains due to genetic susceptibilities, such as the PrkdcR2140C polymorphism. The FVB/N strain without the R2140C mutation resists ADR nephr...
Therapeutic potential of Ganoderma lucidum polysaccharide peptide in Doxorubicin-induced nephropathy: modulation of renin-angiotensin system and proteinuria [0.03%]
灵芝多糖肽治疗阿霉素肾病的潜力：调节肾素-血管紧张素系统和蛋白尿
Hui Fang,Dongmei Lin,Xinxuan Li et al.
Hui Fang et al.
Introduction: In the Doxorubicin (DOX)-induced nephropathy model, proteinuria is a manifestation of progressive kidney injury. The pathophysiology of renal illness is heavily influenced by the renin-angiotensin system (RAS). To reduce renal...
Quercetin-targeted AKT1 regulates the Raf/MEK/ERK signaling pathway to protect against doxorubicin-induced nephropathy in mice [0.03%]
槲皮素通过靶向AKT1调节Raf/MEK/ERK信号通路来保护小鼠免受多柔比星引起的肾病
Wang Yufang,Liu Mingfang,Huang Nan et al.
Wang Yufang et al.
Background: Doxorubicin is an anthracycline antitumor agent commonly used in clinical practice, which has some nephrotoxicity and is often used to establish mouse models of kidney injury for basic medical research. This s...
Danggui Shaoyaosan attenuates doxorubicin induced Nephrotic Syndrome through regulating on PI3K/Akt Pathway [0.03%]
当归芍药散通过调节PI3K/AKT信号通路减轻阿霉素所致肾病综合征
Man Qin,Tianzhao Zhang
Man Qin
The study aimed to explore the role and the underlying mechanism of Danggui Shaoyaosan (DSS) in nephrotic syndrome (NS). NS rat model was induced by doxorubicin injection twice. After DSS treatment, inflammation and oxidative stress index w...
Minnelide combined with Angptl3 knockout completely protects mice with adriamycin nephropathy via suppression of TGF-β1-Smad2 and p53 pathways [0.03%]
米诺利德与Angptl3基因敲除通过抑制TGF-β1-Smad2和p53信号通路完全保护阿霉素肾病小鼠模型
Baowei Ji,Junchao Liu,Yanli Ma et al.
Baowei Ji et al.
Minimal change disease (MCD) is the common type of nephrotic syndrome in children. There is an urgent need to explore new treatment methods as current treatments have many drawbacks and cause significant side effects. Our group found that A...
Huihui Hu,Caipeng Xie,Zeping Weng et al.
Huihui Hu et al.
Introduction: Doxorubicin (DOX), an anthracycline antitumor agent, has been widely used against various solid tumors and hematological malignancies. However, the clinical application of DOX is restricted by its multiple o...
Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition [0.03%]
骨形态发生蛋白通过抑制p38丝裂原活化蛋白激酶改善多柔比星肾病
Takaya Handa,Keita P Mori,Akira Ishii et al.
Takaya Handa et al.
Natriuretic peptides exert multiple effects by binding to natriuretic peptide receptors (NPRs). Osteocrin (OSTN) binds with high affinity to NPR-C, a clearance receptor for natriuretic peptides, and inhibits degradation of natriuretic pepti...
Protective action of ultrasound-guided intraparenchymal transplantation of BMSCs in adriamycin nephropathy rats through the RIPK3/MLKL and NLRP3 pathways [0.03%]
超声引导下骨髓间充质干细胞原位移植通过RIPK3/MLKL和NLRP3通路对ADR肾病大鼠的保护作用研究
Chunjuan Xia,Lishi Shao,Yiqun Ma et al.
Chunjuan Xia et al.
Background: Bone marrow stromal cells (BMSCs) are an effective new strategy for the treatment of kidney diseases. At present, noninvasive and efficient transplantation approaches to homing BMSCs to the renal parenchyma is...
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