Enhancing thermostability of Moloney murine leukemia virus reverse transcriptase through greedy combination of multiple mutant residues [0.03%]
通过多个突变残基的贪婪组合提高莫洛尼氏鼠白血病病毒逆转录酶的热稳定性
Youhui Yang,Jie Zhang,Zhong Li et al.
Youhui Yang et al.
Reverse transcription is crucial in bioengineering and biomedical fields, particularly for genome sequencing and virus diagnosis. Enhancing the thermostability of reverse transcriptase can significantly improve its efficiency and accuracy b...
Optimizing enzyme thermostability by combining multiple mutations using protein language model [0.03%]
利用蛋白质语言模型结合多个突变以优化酶的热稳定性
Jiahao Bian,Pan Tan,Ting Nie et al.
Jiahao Bian et al.
Optimizing enzyme thermostability is essential for advancements in protein science and industrial applications. Currently, (semi-)rational design and random mutagenesis methods can accurately identify single-point mutations that enhance enz...
LipL41 and LigA/LigB Gene Silencing on a LipL32 Knockout Leptospira interrogans Reveals the Impact of Multiple Mutations on Virulence [0.03%]
利用野外分离致病钩端螺旋体LigA/LigB和LipL41基因沉默技术研究多重突变对毒力的影响
Luis Guilherme V Fernandes,Bruno B Foltran,Aline F Teixeira et al.
Luis Guilherme V Fernandes et al.
Leptospirosis is a global zoonosis caused by pathogenic bacteria of the genus Leptospira. The application of the CRISPR/Cas9 system has facilitated the generation of mutants and subsequent evaluation of phenotypes. Since DNA breaks induced ...
Retained colistin susceptibility in clinical Acinetobacter baumannii isolates with multiple mutations in pmrCAB and lpxACD operons [0.03%]
临床中关于pmrCAB和lpxACDoperon发生多个突变的肺炎克雷伯菌中多粘菌素的耐药性问题研究
Mai M Zafer,Amira F A Hussein,Mohamed H Al-Agamy et al.
Mai M Zafer et al.
The progressive increase in the resistance rates to first- and second-line antibiotics has forced the reuse of colistin as last-line treatment for Acinetobacter baumannii infections, but the emergence of colistin-resistant strains is not un...
In vitro development of imipenem/relebactam resistance in KPC-producing Klebsiella pneumoniae involves multiple mutations including OmpK36 disruption and KPC modification [0.03%]
产KPC酶肺炎克雷伯菌中美罗培南/雷利巴坦耐药的体外产生涉及包括OmpK36破坏和KPC修饰在内的多个突变
Eva Gato,Paula Guijarro-Sánchez,Isaac Alonso-García et al.
Eva Gato et al.
Objectives: In order to inform and anticipate potential strategies aimed at combating KPC-producing Klebsiella pneumoniae infections, we analysed imipenem/relebactam and ceftazidime/avibactam single-step mutant frequencie...
Relaxation and single site multiple mutations to identify and control allosteric networks [0.03%]
利用松弛效应和单点多位点突变来鉴定和控制别构网络
Eunjeong Lee,Jasmina S Redzic,Elan Zohar Eisenmesser
Eunjeong Lee
Advances in Nuclear Magnetic Resonance (NMR) spectroscopy have allowed for the identification and characterization of movements in enzymes over the last 20 years that has also revealed the complexities of allosteric coupling. For example, m...
Multiple Mutations within Individual Oncogenes: Examples and Clinical Implications [0.03%]
单个癌基因内的多个突变：实例与临床意义
Keisuke Kataoka,Yuki Saito
Keisuke Kataoka
Gain-of-function mutations had been believed to function as a single mutation in oncogenes, although some secondary mutations, such as EGFR T790M mutations, are frequently acquired in patients that are resistant to tyrosine kinase inhibitor...
Overview and clinical significance of multiple mutations in individual genes in hepatocellular carcinoma [0.03%]
肝癌单基因多个突变的概览及其临床意义
Taisuke Imamura,Yukiyasu Okamura,Keiichi Ohshima et al.
Taisuke Imamura et al.
Background: Multiple mutation (MM) within a single gene has recently been reported as a mechanism involved in carcinogenesis. The present study investigated the clinical significance of MMs in hepatocellular carcinoma (HC...
Molecular characterization of Infectious Bursal Disease Virus isolated in Chile reveals several mutations in VP2 coding region and a reassortment in its genome [0.03%]
智利分离的传染性法氏囊病病毒VP2编码区存在多个突变及其基因组发生基因重组
Miguel Guzmán,Leandro Cádiz,Alejandra Guerrero-Moncayo et al.
Miguel Guzmán et al.
Infectious Bursal Disease (IBD) is a well-described disease in young chickens. It is caused by the Infectious Bursal Disease Virus (IBDV), which has a bi-segmented, double-strand RNA genome. The absence of a lipidic envelope makes IBDV high...
Optimal pathways control fixation of multiple mutations during cancer initiation [0.03%]
癌症发生过程中多个突变固定的最佳路径控制
Hamid Teimouri,Cade Spaulding,Anatoly B Kolomeisky
Hamid Teimouri
Cancer starts after initially healthy tissue cells accumulate several specific mutations or other genetic alterations. The dynamics of tumor formation is a very complex phenomenon due to multiple involved biochemical and biophysical process...
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