Rupert Richard Alexander Bourne,Maria Vittoria Cicinelli,David A Selby et al. Rupert Richard Alexander Bourne et al.

Background: In 2024, WHO included effective refractive error coverage (eREC) into the results framework of the 14th General Programme of Work, which sets a road map for global health and guides WHO's work between 2025 and...

Saurav Basu Saurav Basu

Kristina H Rolin Kristina H Rolin

This study examines epistemic exploitation in the context of social scientific and other research with human participants. Despite researchers' good intentions, attempts to engage members of marginalized social groups can involve elements o...

Nicole Dreisbach,Safiya Campbell,Omar Castillo et al. Nicole Dreisbach et al.

Little is known about how child asthma management programs, and their participants, fared during the first year of the COVID-19 pandemic. We describe the primary modifications made to a child asthma management program in East Harlem, NYC, t...

Clara Freeman,Eric Rawls,Collin D Teich et al. Clara Freeman et al.

Background: The brain's responsiveness to rewarding stimuli is essential for adaptive functioning while deficits in neural reward processing have been linked to the transdiagnostic symptom of anhedonia. Acute or prolonged...

Yogesh Khandokar,Tan Yun Cheng,Carl J H Wang et al. Yogesh Khandokar et al.

Major Histocompatibility Complex I (MHC-I) and MHC-I-like molecules play a central role in mediating immunity. Through their conservation across all taxa of jawed vertebrates, the MHC-I-like proteins have adapted to present non-peptidic ant...

Samuel P Bernhard,Francesc X Ruiz,Stacy Remiszewski et al. Samuel P Bernhard et al.

Sirtuin 2 (SIRT2) is a ubiquitously expressed cellular enzyme that deacylates protein lysine residues using NAD+ as a cofactor. SIRT2-mediated post-translational modifications on a plethora of protein targets position the enzyme to exert a ...

U Kirthana Kunikullaya,PranjicMarija Pranjić,Alison Rigby et al. U Kirthana Kunikullaya et al.

Neuroscientific research on music-based activities has grown rapidly, shedding light on the health benefits of music across various domains. However, the molecular mechanisms by which music influences neuroplasticity in humans remain largel...

Veronika Merold,Indra Bekere,Stefanie Kretschmer et al. Veronika Merold et al.

Oligoadenylate synthetase (OAS) proteins are immune sensors for double-stranded RNA and are critical for restricting viruses. OAS2 comprises two OAS domains, only one of which can synthesize 2'-5'-oligoadenylates for RNase L activation. Exi...

Huaixiang Tian,Ningwei Huang,Chen Chen et al. Huaixiang Tian et al.

Lacticaseibacillus paracasei from diverse traditional fermented foods exhibit unique flavor profiles in dairy products. In this study, 101 Lacticaseibacillus isolates were categorized into four distinct classes, with those originating from ...