Exploring Negative Feedback Mechanisms in the PTEN-ACE Axis: Application of Electrosorb Hydrogel-Based Gene Delivery for Intervertebral Disc Regeneration [0.03%]
基于电吸附水凝胶的基因递送在椎间盘再生中PTEN-ACE轴负反馈机制的研究及应用
Youfeng Guo,Feng Wang,Yu Zhou et al.
Youfeng Guo et al.
Intervertebral disc degeneration (IDD), along with associated low back pain, stands as a primary cause of disability. The renin-angiotensin-aldosterone system has been linked to IDD; however, the mechanisms underlying this relationship have...
Current biological, chemical and physical gene delivery approaches for producing induced pluripotent stem cells (iPSCs) [0.03%]
用于诱导多能干细胞(iPSCs)制备的当前生物、化学和物理基因递送方法
Elahe Izadi,Seyedeh Shima Mohammad,Mazdak Ganjalikhani Hakemi et al.
Elahe Izadi et al.
The discovery of induced pluripotent stem cells (iPSCs) has revolutionized the research platform for disease modeling, drug discovery, cell therapy and regenerative medicine. Due to the importance of iPSCs over the past decade, various stud...
Intelligent Gene Delivery System Functionalized Metal Implants for Fracture Repair via Remodeling Mitochondrial Homeostasis [0.03%]
通过调节线粒体稳态功能化金属植入物的智能基因传递系统促进骨折修复
Gang Zheng,Feng Hu,Mengqian Wu et al.
Gang Zheng et al.
Delayed union and nonunion of fractures are primarily attributed to the impaired osteogenic activities of bone marrow mesenchymal stem cells (BMSCs). Gene therapy targeting BMSCs is emerging as a promising strategy to promote fracture heali...
CD44-targeted RIP3 gene delivery strategy for enhanced cancer therapy via necroptosis and immune modulation [0.03%]
一种针对CD44的RIP3基因传递策略通过坏死性凋亡和免疫调节增强癌症治疗效果
Sang Eun Kim,Soyeon Bak,Jung Hee Park et al.
Sang Eun Kim et al.
Receptor-interacting protein kinase 3 (RIP3)-mediated necroptosis has attracted interest as a potential target for cancer therapy as it boosts tumor immunogenicity. Here, we synthesized a pH-sensitive polymer (CA) by conjugating aminopropyl...
Role of Peptide Molecular Conformation in Improving the Gene Delivery Efficiency of Liposomal Formulations [0.03%]
肽分子构象在脂质体基因递送中的作用研究
Yaohui Du,Chuanmei Tang,Bowen Li et al.
Yaohui Du et al.
The study explored the impact of peptide conformations on the efficiency of nucleic acids transfection by designing two sets of linear (liKK and liRR) and cyclic peptides (cyKK and cyRR) with various sequences (KK: KKKKCRGDSCKKKK and RR: RR...
AAV-mediated transgene delivery targeting spiral ganglion nonsensory cells [0.03%]
运用AAV载体选择性转染耳螺旋神经节非感觉细胞进行基因治疗研究
Joshua S Lin,Nhi V Nguyen,Seiji B Shibata
Joshua S Lin
In-situ neuronal reprogramming in the cochlea through gene therapy offers an avenue to restore hearing loss caused by neuronal damage. One possible source of neuronal conversion is the nonspiral ganglion cells (NSGCs), which include satelli...
Efficient gene delivery admitted by small metabolites specifically targeting astrocytes in the mouse brain [0.03%]
小代谢物特异性靶向小鼠脑星形胶质细胞的高效基因递送
Haibin Zhou,Jiajing Dai,Dong Li et al.
Haibin Zhou et al.
Non-viral gene delivery systems in the treatment of oral cancers: a promising future [0.03%]
非病毒基因传递系统在口腔癌治疗中的应用：光明的前景
Seiichi Yamano,Kenji Inoue
Seiichi Yamano
A dual-fluorescence assay for gene delivery vehicle screening in macrophages with an inflammation-inducible reporter construct [0.03%]
一种用于巨噬细胞中炎症诱导型报告基因载体筛选的双荧光分析方法
Allie Ivy,Shelby N Bess,Shilpi Agrawal et al.
Allie Ivy et al.
Background: Macrophages are a promising target for therapeutics in various applications such as regenerative medicine and immunotherapy for cancer. Due to their plastic nature, macrophages can switch from a non-activated ...
Hypoxia and HIF-1 inhibition enhance lentiviral transduction efficiency: a novel strategy for gene delivery optimization [0.03%]
缺氧和HIF-1抑制可增强慢病毒转导效率：一种优化基因传递的新策略
Qianyu Huo,Wentian Wang,Jiawen Dai et al.
Qianyu Huo et al.
Lentiviral vectors are widely used for stable gene delivery, but their transduction efficiency can be limited by suboptimal experimental conditions. Here, we investigated the role of oxygen concentration and hypoxia-inducible factor 1 (HIF-...
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