The Association of Intraocular Efavirenz Concentrations and HIV-1 Viral Load Among Persons With HIV [0.03%]
眼内埃夫替拉韦浓度与人类免疫缺陷病毒载量之间的关系研究
Pei Zhang,Yiwen Qian,Luoziyi Wang et al.
Pei Zhang et al.
Objective: Efavirenz (EFV) is commonly used in combination antiretroviral therapy. However, in our previous study, many persons living with HIV exhibited ocular complications despite undergoing effective combination antir...
Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens [0.03%]
人类CYP2B6*6（Q172H和K262R）纯合子与标准依非韦伦方案治疗的HIV-1患者中高水平血浆依非韦伦浓度相关
Kiyoto Tsuchiya,Hiroyuki Gatanaga,Natsuo Tachikawa et al.
Kiyoto Tsuchiya et al.
Efavirenz (EFV) is metabolized by cytochrome P450 2B6 (CYP2B6) in the liver. We analyzed the genotypes of CYP2B6 and their contribution to plasma EFV concentrations in 35 EFV-treated patients in International Medical Center of Japan. The me...