Benzimidazole-Derived B2 as a Fluorescent Probe for Bacterial Outer Membrane Vesicle (OMV) Labeling: Integrating DFT, Molecular Dynamics, Flow Cytometry, and Confocal Microscopy [0.03%]
基于苯并咪唑的B₂衍生物作为细菌外膜囊泡标记荧光探针：结合DFT、分子动力学及流式细胞术和共聚焦显微镜实验研究
Francisco Parra,Alexander Carreño,Evys Ancede-Gallardo et al.
Francisco Parra et al.
Bacterial outer membrane vesicles (OMVs) are nanoscale extracellular structures produced by Gram-negative bacteria that are critical for microbial biology and host-pathogen interactions and have great potential in biotechnological applicati...
2-(Cyanomethyl)benzimidazole Derivatives as 1,3-Dicarbonyl Analogues for a Kinetically Controlled Diastereo- and Enantioselective Mannich-Type Reaction Catalyzed by Chiral Phosphoric Acid [0.03%]
二氰甲基苯并咪唑衍生物作为1,3-二羰基类似物用于手性磷酸催化动力学控制的对映面选择性曼尼希反应中
Haiting Ye,Linan Hou,Akihiro Takeda et al.
Haiting Ye et al.
An asymmetric Mannich-type reaction of N-protected 2-(cyanomethyl)benzimidazoles with N-benzoyl imines was developed by using chiral phosphoric acid as a chiral Brønsted acid catalyst. Products having vicinal trisubstituted carbon stereoge...
Synthesis, Photophysical Properties, and Ab Initio Calculations of Dual Solution-Solid-State-Emitting Ethynyl-Extended Boranil Complexes [0.03%]
乙炔延展的联苯并咪唑衍生物的合成、光物理性质及从头算计算（溶液和固态发射双模化合物）
Timothée Stoerkler,Denis Frath,Gilles Ulrich et al.
Timothée Stoerkler et al.
We describe herein the synthesis along with full photophysical and computational studies of three series of boranil complexes (Series I-III), incorporating extended ethynyl substitution, either on the imino side (Series I), on the phenolic ...
Biological assessments of novel ultrasound-synthesized 2-arylbenzimidazole derivatives: antiproliferative and antibacterial effects [0.03%]
新型超声合成2-芳基苯并咪唑衍生物的生物学评价：抗增殖和抗菌作用
Ivana Sokol,Anja Rakas,Dajana Kučić Grgić et al.
Ivana Sokol et al.
This paper describes ultrasound synthesis, structural characterization and biological activity of new derivatives of 2-arylbenzimidazole 12-27 and 1,2,3-triazole derivatives of 2-arylbenzimidazole 28-33. The tautomeric structures of the pre...
Structural Optimization and MD Simulation Study of Benzimidazole Derivatives as Potent Mutant FLT3 Kinase Inhibitors Targeting AML [0.03%]
苯并咪唑衍生物作为针对AML的高效FLT3激酶抑制剂的结构优化和分子模拟研究
Nada Alaa El-Deen,RosaAnna DeFilippis,Amal Kamal Abdel-Aziz et al.
Nada Alaa El-Deen et al.
Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor survival rates in adults, posing a significant economic burden. FMS-like tyrosine kinase 3 (FLT3) mutations are linked to poor prognosis in AML and resistance ...
Advances in Organic Synthesis and Properties Based On Tetraphenylimidazole Derivatives [0.03%]
基于四苯基咪唑衍生物的有机合成及性能研究进展
Huibin Huang,Yang Li,Can Zeng et al.
Huibin Huang et al.
1,2,4,5-Tetraphenylimidazole derivatives exhibit unique conjugated structures, photophysical properties, and multifunctional properties by virtue of the phenyl functional groups introduced at specific positions of the imidazole ring. Howeve...
Exploring the Two-Way Role: Biological and Anti-Epileptic Properties of Imidazole and 2-Mercaptobenzimidazole Derivatives [0.03%]
异咪唑和2-巯基苯并异咪唑衍生物的双向作用：生物学及抗癫痫性能研究
Geetika Goel,Jannat Ul Firdous
Geetika Goel
Imidazole and 2-mercapto benzimidazole analogues are a group of molecules that have various biological activities and good therapeutic potential in the treatment of epilepsy. This review explores their dual role, focusing on their biologica...
Benzimidazole derivatives protect pancreatic β-cells against cytokine-induced apoptosis [0.03%]
苯并咪唑衍生物可保护胰岛β细胞免受细胞因子诱导的细胞凋亡作用
Shafqat Hussain,Sajid Ali Rajput,Khalid Mohammed Khan et al.
Shafqat Hussain et al.
This study describes the synthesis of a series of benzimidazoles 1-30 by treating 1,2-phenylenediamines with aromatic aldehydes. To further investigate the potential of benzimidazole derivatives in safeguarding the INS-1E β-cell line again...
Interaction of half-sandwich Rh(III) ion and some of its complexes with endogenous imidazole derivatives [0.03%]
半夹心铑(III)离子及其配合物与内源组胺衍生物的相互作用
Azza A Hassoon,Attila Szorcsik,Tamás Gajda
Azza A Hassoon
An increasing number of {Rh(η5-Cp*)}2+ complexes are reported to possess promising medical, mostly anticancer activities. In parallel, growing interest has also focused on the interactions between {Rh(η5-Cp*)}2+-based metallodrugs and mac...
Design, synthesis and investigation of new imidazole derivatives with biological activities and antifungal effects [0.03%]
具有生物活性和抗真菌作用的新型咪唑衍生物的设计、合成及研究
Sare Peçe,Derya Osmaniye,Begüm Nurpelin Sağlık Özkan et al.
Sare Peçe et al.
Fungal infections are important types of infection that annually cause the death of many people around the world. Therefore, new antifungal agents that are more effective and less toxic are constantly needed. In this study, new imidazole de...
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