Studying the Effect of Receptors Clustering on Hyaluronic Acid Binding with CD44 and the Cell Entry of Hyaluronic Acid Targeting Nanodrugs at Single Molecule/Particle Level [0.03%]
单分子/颗粒水平研究透明质酸受体聚集对细胞外基质糖胺聚糖透明质酸与受体CD44结合及透明质酸靶向纳米药物细胞摄取的影响
Xuening Li,Zhuang Zhang,Siying Li et al.
Xuening Li et al.
Receptor-ligand interactions on cell membrane play key roles in many physiological and pathological processes, especially in the nanodrug targeted delivery system. Hyaluronic acid (HA) is the main ligand for binding CD44 to modulate the tar...
Higher order receptor clustering due to the IgG3 subclass is necessary for TLR4 signaling and tolerance induction by novel human anti-TLR4 antibodies [0.03%]
新型人抗TLR4抗体诱导TLR4信号传导和耐受性需要IgG3亚类引起的较高阶受体聚簇现象
Luke S Heuer,Nicolle Sweeney,Manuel Rojas et al.
Luke S Heuer et al.
We have previously demonstrated that an IgG3 agonistic TLR4/MD2 antibody reversed acute murine Type 1 diabetes (T1D), induced immune tolerance, and induced long-term endosomal sequestration of TLR4/MD2. We hypothesized that the IgG3 Fc was ...
INBRX-106: a hexavalent OX40 agonist that drives superior antitumor responses via optimized receptor clustering [0.03%]
INBRX-106：一种六价OX40激动剂通过优化受体聚集驱动更强的抗肿瘤反应
Nisha Holay,Rashi Yadav,Sae Jeong Ahn et al.
Nisha Holay et al.
Background: Immunotherapies targeting immune checkpoint inhibitors have revolutionized cancer treatment but are limited by incomplete patient responses. Costimulatory agonists like OX40 (CD134), a tumor necrosis factor re...
A Nonfused Ring Electron Acceptor with Aggregation-Induced Emission Assistance Achieving Over 20% Efficiency in Organic Solar Cells [0.03%]
一种具有聚集诱导发光效应的非共轭稠环电子受体用于有机太阳能电池获得超过20%效率
Kun Li,Qian Xie,Cunbin An et al.
Kun Li et al.
The development of non-fused ring electron acceptors (NFREAs) with high electroluminescence quantum efficiency (EQEEL) is essential for advancing the commercialization of organic solar cells (OSCs), due to their low-cost and minimal energy ...
Agrin/Dok-7-induced JPH2 phosphorylation in muscle cells is involved in AChR clustering [0.03%]
Agrin/Dok-7诱导的肌肉细胞中JPH2磷酸化参与乙酰胆碱受体聚集作用
Beibei Wang,Mengge Cui,Huan Liu et al.
Beibei Wang et al.
The neuromuscular junction (NMJ) performs the crucial function of controlling skeletal muscle contraction. NMJ formation depends on the Agrin/Lrp4/MuSK/Dok-7 signaling pathway. However, signaling downstream of Dok-7 remains incompletely und...
In silico design of magnetic, polymeric synthetic receptor targeting clumping factor A, for the specific capture and detection of Staphylococcus aureus [0.03%]
基于计算机的设计磁性、聚类合成受体以靶向葡萄球菌凝固酶A，从而特异性地捕获和检测金黄色葡萄球菌
Kritika Narula,Prashant Mishra
Kritika Narula
Rapid diagnosis of Staphylococcus aureus (S. aureus) is critical for both therapy and infection control programs. Currently available rapid bacterial detection methods such as polymerase chain reaction (PCR) requires expensive equipment and...
Random Terpolymerization as a Design Strategy to Modulate Aggregation in NDI-Based Polymer Acceptors for All-Polymer Solar Cells [0.03%]
NDI基聚合物受体中随机三元共聚调控行为策略用于全聚合物太阳能电池聚集效应的研究
Dasol Chung,Stephanie Samson,Sungmo Moon et al.
Dasol Chung et al.
Naphthalene diimide (NDI)-based conjugated polymers are prominent polymer acceptors in all-polymer solar cells (all-PSCs). However, these polymers tend to exhibit strong self-aggregation, which can cause excessive phase separation and hinde...
Receptor clustering tunes and sharpens the selectivity of multivalent binding [0.03%]
受体聚类调节并增强了多价结合的选择性
Zhaoping Xie,Stefano Angioletti-Uberti,Jure Dobnikar et al.
Zhaoping Xie et al.
The immune system exploits a wide range of strategies to combine sensitivity with selectivity for optimal response. We propose a generic physical mechanism that allows tuning the location and steepness of the response threshold of cellular ...
CRISPR-Cas12a-Assisted DNA Circuit for Nonmicroscopic Detection of Cell Surface Receptor Clustering [0.03%]
基于CRISPR-Cas12a的DNA线路实现细胞表面受体聚集的非显微镜检测
Yahui Gao,Yan Shan Ang,Lin-Yue Lanry Yung
Yahui Gao
Protein-protein interactions (PPIs) on the cell surface have been of great interest due to their high clinical relevance and significance; however, the methods for detecting PPIs heavily rely on microscopic instruments. In this work, we des...
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