Integration of Single Pass Tangential Flow Filtration and High Performance Countercurrent Membrane Purification for Intensification of Monoclonal Antibody Processing [0.03%]
集成单程切向流过滤和高性能连续逆流膜纯化技术以强化单克隆抗体工艺
Mirko Minervini,Aylin Mohammadzadehmarandi,Ali Behboudi et al.
Mirko Minervini et al.
There is increasing interest in the development of intensified processes that can provide significant reductions in manufacturing costs for monoclonal antibody (mAb) products. This study examines the performance of an integrated membrane pr...
Predictive modeling of single pass tangential flow filtration for continuous biomanufacturing [0.03%]
连续生物制造的单程切向流过滤的预测模型
Madeline Fuchs,Rajan Bhawnani,Sobhana A Sripada et al.
Madeline Fuchs et al.
Opportunities for process intensification have made continuous biomanufacturing an area of active research. While tangential flow filtration (TFF) is typically employed within the biologics purification train to increase drug substance conc...
Single-Pass Tangential Flow Filtration (SPTFF) of Nanoparticles: Achieving Sustainable Operation with Dilute Colloidal Suspensions for Gene Therapy Applications [0.03%]
用于基因治疗的纳米颗粒单程切向流过滤（SPTFF）：使用稀溶胶实现可持续操作
Akshay S Chaubal,Andrew L Zydney
Akshay S Chaubal
Recent approval of several viral-vector-based therapeutics has led to renewed interest in the development of more efficient bioprocessing strategies for gene therapy products. Single-Pass Tangential Flow Filtration (SPTFF) can potentially p...
Investigating the combination of single-pass tangential flow filtration and anion exchange chromatography for intensified mAb polishing [0.03%]
探究同时进行单程切向流过滤和阴离子交换色谱结合用于抗体抛光强化的方法
Thomas Elich,Elizabeth Goodrich,Herb Lutz et al.
Thomas Elich et al.
There is growing interest within the biopharmaceutical industry to improve manufacturing efficiency through process intensification, with the goal of generating more product in less time with smaller equipment. In monoclonal antibody (mAb) ...
Ultrafiltration behavior of partially retained proteins and completely retained proteins using equally-staged single pass tangential flow filtration membranes [0.03%]
等级一致的单程切向流过滤膜对部分截留蛋白和完全截留蛋白的超滤行为研究
Abhiram Arunkumar,Junyan Zhang,Nripen Singh et al.
Abhiram Arunkumar et al.
This work examines the ultrafiltration behavior of partially retained proteins like lysozyme and completely retained proteins like monoclonal antibodies using single pass tangential flow filtration (SPTFF) modules with different screen chan...
Leveraging single-pass tangential flow filtration to enable decoupling of upstream and downstream monoclonal antibody processing [0.03%]
利用单程切向流过滤来实现上游和下游单克隆抗体工艺的解耦
Alex Brinkmann,Sanaa Elouafiq,John Pieracci et al.
Alex Brinkmann et al.
Decoupling upstream and downstream operations in biopharmaceutical production could enable more flexible manufacturing operations and could allow companies to leverage strategic or financial benefits that would be otherwise unattainable. A ...
Single pass tangential flow filtration to debottleneck downstream processing for therapeutic antibody production [0.03%]
一种单程切向流过滤技术可解除治疗性抗体生产的下游工艺瓶颈问题
Jemelle Dizon-Maspat,Justin Bourret,Anna D&#x;Agostini et al.
Jemelle Dizon-Maspat et al.
As the therapeutic monoclonal antibody (mAb) market continues to grow, optimizing production processes is becoming more critical in improving efficiencies and reducing cost-of-goods in large-scale production. With the recent trends of incre...