Dose-dependent testis infiltration of peritubular macrophages after MEHP exposure of Peri-pubertal rats and their role in the recovery of spermatogenesis [0.03%]
邻苯二甲酸酯代谢物MEHP暴露诱导大鼠睾丸支持细胞巨噬细胞浸润及其参与生精功能恢复的作用及机制研究
Richa Tiwary,Xin Fang,Vivian Nguyen et al.
Richa Tiwary et al.
We have previously reported that acute MEHP exposure resulted in a significant increase in peritubular macrophages along with differentiating spermatogonia. Here, we hypothesize that the recruitment of peritubular macrophages is MEHP dose-d...
Dose-Dependent Effects of TGF-β Inhibition on Osteoblast Differentiation and Wound Healing [0.03%]
TGF-β抑制对成骨细胞分化和伤口愈合的剂量依赖性影响
Nihal Almuraikhi,Latifa Alkhamees,Sumaiya Tareen et al.
Nihal Almuraikhi et al.
TGF-β is a multifunctional pathway that controls significant cellular and physiological processes and several pathological activities. TGF-β-induced signaling can be triggered upon binding to specific receptors to initiate the transcripti...
Atypical Neutrophilic Dermatosis Induced by Ibrutinib: A Dose-Dependent Cutaneous Adverse Reaction [0.03%]
伊布替尼引起的不典型中性粒细胞皮肤病：剂量依赖性皮肤不良反应
Jeanne Renuy,Ariane Fizazi,Celine Girard et al.
Jeanne Renuy et al.
Human bone marrow mesenchymal stem cell-derived extracellular vesicles induce inverse dose-dependent anti-fibrotic effects in human myofibroblast cultures and bleomycin-injured mice with pulmonary fibrosis [0.03%]
人骨髓间充质干细胞源性外泌体在人体肌成纤维细胞培养和博来霉素损伤的小鼠肺纤维化模型中诱导剂量依赖性的抗纤维化作用
Jennie S Charoenphannathon,Pui D Wong,Simon G Royce et al.
Jennie S Charoenphannathon et al.
Idiopathic pulmonary fibrosis (IPF) is a fatal condition associated with excessive interstitial collagen accumulation and irreversible lung function decline, for which there is no effective cure. Hence, this study evaluated the dose-depende...
G Proteins-Associated Dose-Dependent Effects of Oxytocin on Oxytocin Neuronal Activity and Astrocytic Plasticity of the Supraoptic Nucleus [0.03%]
催产素剂量依赖性效应作用于室管膜下区神经干细胞增殖和分化的影响及机制研究摘要
Xiao-Yu Liu,Shuo Ling,Yang Liu et al.
Xiao-Yu Liu et al.
Dose-dependent neuromodulation has been well established; however, the molecular mechanisms underlying astrocytic involvement in this process remain largely unexplored. Using the autoregulation of supraoptic oxytocin (OT) neurons (OTNs) as ...
Magnesium and Zinc Dose-Dependently Stabilize Rat Peritoneal Mast Cells and Enhance the Effects of Adrenaline [0.03%]
镁和锌剂量依赖性地稳定大鼠腹膜肥大细胞并增强肾上腺素的作用
Itsuro Kazama,Hiroyuki Sonobe,Junko Shida
Itsuro Kazama
Background/aims: Magnesium and zinc are vital trace elements found in numerous foods and dietary supplements. In addition to their antioxidant, anticancer, antibacterial, and anti-inflammatory effects, clinical research h...
Time- and dose-dependent activation of the NLRP3 and MyD88/NF-κB pathways by Trueperella pyogenes membrane vesicles in bovine endometrial epithelial cells [0.03%]
时间依赖性和剂量依赖性激活链球菌膜囊泡诱导牛子宫内膜上皮细胞NLRP3和MyD88/NF-κB信号通路
Dengfu Li,Haixia Li,Zhu Wang et al.
Dengfu Li et al.
Trueperella pyogenes is an opportunistic pathogen frequently associated with bovine endometritis, yet the mechanisms by which it induces uterine inflammation remain incompletely understood. In this study, we investigated the effects of T. p...
Therapeutic efficacy of rhoifolin in type 2 diabetes mellitus: Effects on metabolic parameters, hepatic function, and oxidative stress: a dose-dependent study [0.03%]
rhoifolin治疗2型糖尿病疗效：代谢参数、肝功能及氧化应激效应的剂量依赖性研究
Sndos Z Fattiny,Manal Abdulaziz Binobead,Abu ElGasim A Yagoub et al.
Sndos Z Fattiny et al.
Background/objectives: Diabetes is one of the most prevalent chronic disorders globally and is linked to obesity. Research has shown that rhoifolin (ROF) can effectively treat metabolic illnesses. This study examines the ...
Dose-dependent effects of capsaicin on intestinal morphology and microbiota composition in mice: Structural, immunohistochemical, and microbial insights [0.03%]
辣椒素对小鼠肠道形态和微生物组成剂量依赖性影响的结构、免疫组织化学和微生物见解
Kai Li,Jianghai Xu,Siying Chen et al.
Kai Li et al.
Background and aim: Capsaicin (CAP), the pungent component of chili peppers, possesses diverse bioactive properties, including antioxidant, anti-inflammatory, and antimicrobial effects. However, its impact on gastrointest...
Repeated Administration of Pharmaceutical-Grade Medium-Chain Triglycerides, a Common Pharmacologic Excipient, Confers Dose-Dependent Toxicity by the Intraperitoneal but Not Oral Route in Mice [0.03%]
药用中链三甘酯重复腹腔给药剂量依赖性地导致小鼠毒性，而口服无此作用
Mitzi Adler-Wachter,Julia Y Tsai,Brendan N Schweitzer et al.
Mitzi Adler-Wachter et al.
Pharmaceutical-grade medium-chain triglycerides (MCTs) are common excipients for in vivo pharmacological studies in laboratory animals and as an experimental therapeutic in certain metabolic and neurologic disorders. In this study, we exami...
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