MOLECULAR BASIS AND KEY BIOLOGICAL PROCESSES FOR MYOCARDIAL REGENERATION: TRANSCRIPTOMIC ANALYSIS OF ACUTE MYOCARDIAL INFARCTION IN A TRANSLATIONAL OVINE MODEL [0.03%]
心肌再生的分子基础及关键生物学过程： translational 羊急性心肌梗死转录组分析
Cristian Nahuel Nuñez Pedrozo,Francisco Raúl Borzone,Agustina Varela et al.
Cristian Nahuel Nuñez Pedrozo et al.
Background: Recently, transcriptomic analysis has been key in identifying therapeutic targets in cardiovascular regeneration. The postnatal loss of cardiomyocyte proliferative capacity has been linked to the transition fr...
Decoding the Olfactory Deception: Molecular Basis into Chilo suppressalis' Recognition of the Lethal Trap Plant Vetiveria zizanioides [0.03%]
解密嗅觉欺骗：害堤夜蛾识别致死陷阱植物香根草的分子机制
Qi-Han Lu,Pan-Pan Zhang,Jia-Hang Wei et al.
Qi-Han Lu et al.
The striped stem borer (Chilo suppressalis), a devastating rice (Oryza sativa L.) pest, exhibits a paradoxical oviposition preference for vetiver grass (Vetiveria zizanioides L.), a nonhost plant causing complete larval mortality. To elucid...
Molecular Basis of Anxiety: A Comprehensive Review of 2014-2024 Clinical and Preclinical Studies [0.03%]
焦虑症的分子基础：2014-2024年临床和前临床研究综合回顾
Ermis Merkouris,Alexandra Brasinika,Meropi Patsiavoura et al.
Ermis Merkouris et al.
Anxiety disorders are among the most common psychiatric conditions that significantly impair one's quality of life and place a significant burden on healthcare systems. Conventional treatments have certain restraints, such as potential side...
The cell-surface shared proteome of astrocytes and neurons and the molecular foundations of their multicellular interactions [0.03%]
星形胶质细胞和神经元的表面共享蛋白质组及它们多细胞相互作用的分子基础
Ling Wu,Vijaya Pandey,Vanessa H Casha et al.
Ling Wu et al.
Neurons and astrocytes are predominant brain cells that extensively interact, but the molecular basis of their interactions remains largely unexplored. We identified and mapped striatal astrocytic and neuronal cell-surface proteins (CSPs) a...
Ovarian transcriptome analyses indicate that weak juvenile hormone signaling underlies the molecular basis of oogenesis deficiencies in mosquitoes [0.03%]
蚊子卵巢转录组分析表明，薄弱的青年激素信号传导是其卵发生缺陷的分子基础
Monika M Wiśniewska,Martin Kolísko,Petra Berková et al.
Monika M Wiśniewska et al.
Background: Juvenile hormone (JH) is synthesized by the corpora allata (CA) and controls development and reproduction in insects. We recently used CRISPR/Cas9 to establish a line lacking the enzyme that catalyzes the fina...
A molecular basis of Ferredoxin Reductase (FdxR) mutations that result in mitochondriopathies [0.03%]
线粒体病的 Ferredoxin还原酶(FdxR)突变的分子基础
Amit Kumar,Janie E McGlohon,D Fernando Estrada
Amit Kumar
Inherited mutations in the Ferredoxin Reductase (FdxR) gene can result in a spectrum of disorders that include auditory and optic neural atrophies as well as adrenal insufficiency. FdxR (also referred to as Adrenodoxin Reductase) is a flavo...
Molecular basis of the hepatobiliary tropism of typhoid toxin promoting Salmonella pathogenicity [0.03%]
泰夫毒素的分子基础及其对伤寒沙门氏菌致病性的促进作用促使肝胆趋向性
Hwa Young Kim,Gi Young Lee,Andrew J Thompson et al.
Hwa Young Kim et al.
Salmonella Typhi assembles and secretes two forms of typhoid toxin by using two receptor-binding subunits, PltB and PltC. Unlike PltB typhoid toxin, little is known about the tropism and functional consequences of PltC typhoid toxin. Here, ...
Yichen Liu,Jason D Galpin,Christopher A Ahern et al.
Yichen Liu et al.
Voltage-gated sodium channels initiate action potentials and control electrical signaling throughout the animal kingdom. Fast inactivation is an essential auto-inhibitory mechanism and requisite component of sodium channel physiology. Recen...
Illuminating the intricate role of genetic factors in chronic low back pain: from the molecular basis of onset to the determination of susceptibility and the search for novel therapeutic avenues [0.03%]
遗传因素在慢性下腰痛发生发展中的作用：从发病机制到易感性鉴定以及探索新的治疗途径
Ding-Qiang Chen,Zhi-Qiang Que,Wen-Bin Xu et al.
Ding-Qiang Chen et al.
Background: Interleukin 6 receptor (IL6R) inhibitors are effective drugs as therapy for rheumatoid arthritis (RA). However, few studies on IL6R inhibition for relieving chronic low back pain (CLBP) have been conducted. Th...
Yang Suo,Justin G Fedor,Han Zhang et al.
Yang Suo et al.
Hyperuricemia is a condition when uric acid, a waste product of purine metabolism, accumulates in the blood. Untreated hyperuricemia can lead to crystal formation of monosodium urate in the joints, causing a painful inflammatory disease kno...
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