Anti-Tumorigenic Effect of a Novel Derivative of 2-Hydroxyoleic Acid and the Endocannabinoid Anandamide on Neuroblastoma Cells [0.03%]
一种新型2-羟基油酸与内源大麻素安酰胺的衍生物对神经母细胞瘤细胞的抗肿瘤作用
Hana Golan,Raphael Mechoulam,Reem Smoum et al.
Hana Golan et al.
Modulation of the endogenous cannabinoid system has been suggested as a potential anticancer strategy. In the search for novel and less toxic therapeutic options, structural modifications of the endocannabinoid anandamide and the synthetic ...
Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome through Modulation of Microbiome in the Gut-Lung Axis [0.03%]
内源大麻素花生四烯酸氨酚酸通过调控肠道-肺轴菌群改变急性呼吸窘迫综合征
Muthanna Sultan,Kiesha Wilson,Osama A Abdulla et al.
Muthanna Sultan et al.
Acute respiratory distress syndrome (ARDS) is a serious lung condition characterized by severe hypoxemia leading to limitations of oxygen needed for lung function. In this study, we investigated the effect of anandamide (AEA), an endogenous...
The endocannabinoid anandamide affects the synthesis of human syncytiotrophoblast-related proteins [0.03%]
内源大麻素AEA影响人合胞体滋养层相关蛋白的合成
M A Costa,B M Fonseca,A Mendes et al.
M A Costa et al.
The human syncytiotrophoblast (hST) has a major role in the production of important placental hormones. Several molecules regulate hST endocrine function but the role of endocannabinoids in this process is still unknown. Here, we report tha...
Phytoestrogens enhance the vascular actions of the endocannabinoid anandamide in mesenteric beds of female rats [0.03%]
植物雌激素可增强植物雌激素在雌性大鼠肠系膜血管丛中对内源性大麻素安酰胺的作用
Roxana N Peroni,Tamara Abramoff,Isabel Neuman et al.
Roxana N Peroni et al.
In rat isolated mesenteric beds that were contracted with NA as an in vitro model of the vascular adrenergic hyperactivity that usually precedes the onset of primary hypertension, the oral administration (3 daily doses) of either 10 mg/kg g...
The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway [0.03%]
内源大麻素花生四烯乙醇胺通过激活非经典的Wnt信号通路抑制胆管癌生长
Sharon DeMorrow,Heather Francis,Eugenio Gaudio et al.
Sharon DeMorrow et al.
Cholangiocarcinomas are cancers that have poor prognosis and limited treatment options. The noncanonical Wnt pathway is mediated predominantly by Wnt 5a, which activates a Ca(2+)-dependent pathway involving protein kinase C, or a Ca(2+)-ind...
The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs [0.03%]
花生四烯酸乙醇胺（安那美德）通过环氧化酶产物增加分离兔肺的肺动脉压
Hans Wahn,Jürgen Wolf,Florian Kram et al.
Hans Wahn et al.
Several cannabinoids elicit systemic vasodilation, mainly via CB1 cannabinoid and vanilloid receptors. However, effects in the pulmonary circulation are unknown. Using the isolated, ventilated, buffer-perfused rabbit lung, we have shown tha...