A Simplified and Robust Immunofluorescence Labeling Method for Complex 3D Cell Cultures: Minimizing Manipulation and Maximizing Data in Whole-Mount Analysis of Organoids, Spheroids, and Co-culture Models [0.03%]
一种简化且稳健的免疫荧光标记方法，用于复杂3D细胞培养：在器官样结构、类器官和共培养模型的整体分析中减少操作并增加数据量
Gamze Demirel,Olgu E Tok,Ranan G Aktas
Gamze Demirel
Whole-mount imaging and labeling of 3D organoids and spheroids offer unparalleled insights into spatial biology, organogenesis, disease mechanisms, and cancer cell dynamics within a physiologically relevant 3D context. Those techniques in b...
High-Throughput Human Gut Immune Co-Culture Model for Evaluating Inflammatory Bowel Disease Anti-Inflammatory Therapies [0.03%]
高通量人类肠道免疫共培养模型，用于评估炎症性肠病的抗炎疗法
Swetha Peddibhotla,Lauren A Boone,Earnest Taylor et al.
Swetha Peddibhotla et al.
Current treatments for inflammatory bowel disease (IBD) are often ineffective long-term, as many patients ultimately become unresponsive to anti-inflammatory drugs. The need for improved therapeutics is urgent. Animal models utilized for dr...
Physiologically relevant coculture model for oral microbial-host interactions [0.03%]
口腔微生物-宿主互作的生理相关共培养模型
Zeyang Pang,Nicole M Cady,Lujia Cen et al.
Zeyang Pang et al.
Understanding microbial-host interactions in the oral cavity is essential for elucidating oral disease pathogenesis and its systemic implications. In vitro bacteria-host cell coculture models have enabled fundamental studies to characterize...
Primary cilium restricts TGF-β/SMAD signaling induced RIBEs in the co-culture model [0.03%]
原纤毛通过限制TGF-β/SMAD信号诱导的RIBE在共培养模型中发挥重要作用
Pei Qu,Yuan Wang,Zhiang Shao et al.
Pei Qu et al.
Transforming growth factor β (TGF-β) is the predominant cytokine responding to ionizing radiation and participates in radiation induced bystander effects (RIBEs). Primary cilia (PC) coordinates with multiple signaling pathways, exhibit sp...
APOE mediates the coupling of myogenesis and lipid metabolism in skeletal muscle: decoding intercellular crosstalk via a cell co-culture model [0.03%]
APOE介导脂代谢与骨骼肌成肌过程偶联：基于细胞共培养模型的跨细胞通讯研究
Yaping Song,Jiupan Zhang,Dongmei Yang et al.
Yaping Song et al.
The growth and lipid accumulation of skeletal muscle directly affects the yield and meat quality characteristics of beef, which is the result of the interaction between skeletal muscle cells (SMCs) and intramuscular adipocytes (IMAs). There...
Validation of a Cystic Fibrosis Co-Culture Model for the Identification of Dual Acting Compounds with Antibiotic and Antibiotic Adjuvant Properties [0.03%]
用于鉴定具有抗生素和抗生素增效性能的双效化合物的囊性纤维化共培养模型的有效性验证
Anne E Mattingly,Haoting Li,Roberta J Melander et al.
Anne E Mattingly et al.
Infections in the lungs of cystic fibrosis (CF) patients are often polymicrobial in nature, typically comprising Pseudomonas aeruginosa and Staphylococcus aureus. Compounds that act as an antimicrobial agent against one of these pathogens, ...
In vitro co-culture model of Trichomonas vaginalis, Candida albicans, and Lactobacillus crispatus: a system for assessing antimicrobial activity and microorganism interactions in vaginitis [0.03%]
应用阴道炎抗菌活性及微生物相互作用评估的滴虫、白色念珠菌和乳杆菌体外共培养模型
Fernanda Gomes Cardoso,Luisa Trindade Dos Santos,Saulo Almeida Menezes et al.
Fernanda Gomes Cardoso et al.
Trichomonas vaginalis is a flagellated protozoan causing trichomoniasis, the most common non-viral sexually transmitted infection. It is associated with various complications, particularly in asymptomatic carriers. Another major cause of va...
Tumor organoid-immune co-culture models: exploring a new perspective of tumor immunity [0.03%]
类器官-免疫共培养模型：肿瘤免疫的新视角探索研究
Jing Wang,Xiaoyue Tao,Jialong Zhu et al.
Jing Wang et al.
Recent advancements in technology have significantly expanded the scope of tumor research, progressing from the study of individual cells to more intricate tissue and organ-level analyses. Tumor organoids have emerged as a highly realistic ...
Dual Antibacterial and Soft-Tissue-Integrative Effect of Combined Strontium Acetate and Silver Nitrate on Peri-Implant Environment: Insights from Multispecies Biofilms and a 3D Coculture Model [0.03%]
乙酸锶和硝酸银联合对种植体周围环境抗菌及软组织整合的协同作用：基于多物种菌斑和三维共培养模型的研究
Marjan Kheirmand-Parizi,Katharina Doll-Nikutta,Carina Mikolai et al.
Marjan Kheirmand-Parizi et al.
Creation of a biological seal and efficient antibacterial qualities in the peri-implant environment is essential for the success of dental implants. Therefore, novel multifunctional strategies are being developed to address these issues, ai...
A vascular endothelial cell, neuron, and microglia tri-culture model to study hypertension-related depression [0.03%]
高血压相关抑郁的血管内皮细胞、神经元和小胶质细胞三共培养模型研究
Hongxia Zhao,Lingge Huang,Jian Liu et al.
Hongxia Zhao et al.
Hypertension-related Depression (HD) is a complex mental disorder that exerts a significant negative impact on patients' quality of life. Previous studies have demonstrated that damages to vascular endothelial and hippocampus are the primar...
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