Covalent Recruitment of NEDD4 for Targeted Protein Degradation: Rational Design of Small Molecular Degraders [0.03%]
共价招募NEDD4蛋白以实现靶向降解：理性设计小分子致蓄积化合物
Xiaoqiang He,Shihan Zeng,Yalei Wen et al.
Xiaoqiang He et al.
Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy for treating various diseases. However, current small molecule degraders predominantly rely on a limited set of E3 ubiquitin ligases, such as CRBN and VHL, w...
Covalent recruitment of polymers and nanoparticles onto glycan-engineered cells enhances gene delivery during short exposure [0.03%]
通过糖工程细胞共价募集聚合物和纳米颗粒可有效提高瞬时基因传递效率
Qiao Tang,Ruben M F Tomás,Matthew I Gibson
Qiao Tang
Non-viral gene delivery with cationic polymers/nanoparticles relies on iterative optimization of the carrier to achieve delivery. Here we demonstrate, instead, that precision engineering of cell surfaces to covalently capture a polyplex acc...
Qian Shao,Tuong Nghi Duong,Inji Park et al.
Qian Shao et al.
14-3-3 proteins have a unique ability to bind and sequester a multitude of diverse phosphorylated signaling proteins and transcription factors. Many previous studies have shown that interactions of 14-3-3 with specific phosphorylated substr...