TBK1 is a signaling hub in coordinating stress-adaptive mechanisms in head and neck cancer progression [0.03%]
TBK1是协调头颈癌进展中应激适应机制的信号中心
Hyo Jeong Kim,Haeng-Jun Kim,Sun-Yong Kim et al.
Hyo Jeong Kim et al.
Tumorigenesis is closely linked to the ability of cancer cells to activate stress-adaptive mechanisms in response to various cellular stressors. Stress granules (SGs) play a crucial role in promoting cancer cell survival, invasion, and trea...
Cilostazol counteracts mitochondrial dysfunction in hepatic encephalopathy rat model: Insights into the role of cAMP/AMPK/SIRT1/ PINK-1/parkin hub and p-CREB /BDNF/ TrkB neuroprotective trajectory [0.03%]
西洛他唑在肝性脑病大鼠模型中的线粒体保护机制：cAMP/AMPK/SIRT1/PINK-1/parkin信号枢纽及p-CREB/BDNF/TrkB神经营救途径的见解
Enas S Gad,Sara A Aldossary,Mona R El-Ansary et al.
Enas S Gad et al.
A devasting stage of chronic hepatic dysfunction is strictly correlated with neurological impairment, signifying hepatic encephalopathy (HE). HE is a multifactorial condition; therefore, hyperammonemia, oxidative stress, neuroinflammation, ...
Bystanders or active players: the role of extra centrosomes as signaling hubs [0.03%]
旁观者还是积极的参与者：作为信号中心的额外中心体的作用
Madison M Purkerson,Sarah R Amend,Kenneth J Pienta
Madison M Purkerson
Centrosomes serve as microtubule-organizing organelles that function in spindle pole organization, cell cycle progression, and cilia formation. A non-canonical role of centrosomes that has gained traction in recent years is the ability to a...
Sarah J Kierans,Cormac T Taylor
Sarah J Kierans
Glycolysis is a highly conserved metabolic pathway responsible for the anaerobic production of adenosine triphosphate (ATP) from the breakdown of glucose molecules. While serving as a primary metabolic pathway in prokaryotes, glycolysis is ...
Transcriptional profiling identifies IL-33-expressing intestinal stromal cells as a signaling hub poised to interact with enteric neurons [0.03%]
转录组谱型鉴定出表达IL-33的肠道基质细胞是一种与肠神经元相互作用的信号集散中心
Patrycja M Topczewska,Anna Savvopoulou,Catalina Cosovanu et al.
Patrycja M Topczewska et al.
Recent advancements in mucosal immunology have unveiled a complex network of intercellular connections within diverse tissues, shedding light on the unique properties of different cell types. Central to this intricate network is the cytokin...
Probing cognitive flexibility in Shank2-deficient mice: Effects of D-cycloserine and NMDAR signaling hub dynamics [0.03%]
探究Shank2缺陷型小鼠的认知灵活性：D-环丝氨酸和NMDA受体信号枢纽动态的影响
Samia Afzal,Nora Dürrast,Iman Hassan et al.
Samia Afzal et al.
Neurodevelopmental disorders such as autism spectrum disorder (ASD) have a heterogeneous etiology but are largely associated with genetic factors. Robust evidence from recent human genetic studies has linked mutations in the Shank2 gene to ...
Jnk1 and downstream signalling hubs regulate anxiety-like behaviours in a zebrafish larvae phenotypic screen [0.03%]
沉默JNK1及下游信号分子可调节斑马鱼透明幼体的焦虑样行为缺陷
Ye Hong,Christel Sourander,Benjamin Hackl et al.
Ye Hong et al.
Current treatments for anxiety and depression show limited efficacy in many patients, indicating the need for further research into the underlying mechanisms. JNK1 has been shown to regulate anxiety- and depressive-like behaviours in mice, ...
Yunli Wang,Jinghua Yang
Yunli Wang
Neuronal health is closely linked to the homeostasis of intracellular organelles, and organelle dysfunction affects the pathological progression of neurological diseases. In contrast to isolated cellular compartments, a growing number of st...
Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function [0.03%]
泛素连接酶和信号中枢MYCBP2对于EPHB2酪氨酸激酶受体的功能是必需的
Chao Chang,Sara L Banerjee,Sung Soon Park et al.
Chao Chang et al.
Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes during development and throughout adulthood. This versatility is likely facilitated by the ability of Eph receptors to signal through diverse cellular...
SCD1 is the critical signaling hub to mediate metabolic diseases: Mechanism and the development of its inhibitors [0.03%]
SCD1是代谢性疾病关键信号枢纽：机制及抑制剂开发进展
Qin Sun,Xiaorui Xing,Huanyu Wang et al.
Qin Sun et al.
Metabolic diseases, featured with dysregulated energy homeostasis, have become major global health challenges. Patients with metabolic diseases have high probability to manifest multiple complications in lipid metabolism, e.g. obesity, insu...
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